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8 results for "clinical trials" in manual

Earth Repair Manual

manual.warondisease.org/knowledge/appendix/parameters-and-calculations / Overview

Methodology, Parameters, and Calculations

Parameter definitions, formulas, uncertainty ranges, and data sources.

Earth Repair Manual

manual.warondisease.org/knowledge/economics/1-pct-treaty-impact / Abstract

The 1% Treaty: An Incentive-Compatible Approach to Ending War and Disease

6,650 diseases (95% CI: 5,700 diseases-8,232 diseases) have zero FDA-approved treatments; at current trial capacity, exploring them takes ~443 years (95% CI: 255 years-841 years). Redirecting 1% of military spending scales capacity 12.3x (95% CI: 4.92x-50.8x), cutting the timeline to ~36 years (95% CI: 8.15 years-106 years) and preventing 10.7 billion deaths (95% CI: 6.24 billion deaths-20.3 billion deaths). At $0.00177 (95% CI: $0.000809-$0.00354)/DALY, 50.3kx (95% CI: 25.0kx-111.1kx) more cost-effective than the best existing interventions. The result holds across every specified adoption pathway.

Earth Repair Manual

manual.warondisease.org/knowledge/appendix/optimal-budget-generator-spec / Abstract

The Optimal Budget Generator: A Causal Inference Protocol for Maximizing Median Health and Wealth Through Public Goods Funding

The Optimal Budget Generator (OBG) uses causal inference, diminishing returns modeling, and cost-effectiveness evidence to determine optimal public goods funding levels that maximize two terminal general-welfare metrics: real after-tax median income growth and median healthy life years. For each spending category, OBG estimates an Optimal Spending Level (OSL) and produces a gap analysis showing where current government budgets are over- or underfunded relative to evidence-based benchmarks. The Budget Impact Score (BIS) measures confidence in each recommendation based on the quality of causal evidence.

Earth Repair Manual

manual.warondisease.org/knowledge/strategy/ic2ewd-supporter-survey / 1) Binary choice: the two campaigns

Join the International Campaign to End War and Disease

Full case for getting organizations and individuals to endorse IC2EWD. Binary A/B choice, ICAN/ICBL precedent, post-WWII data, capital misallocation, fiduciary duty, margin flip, PCT engine, three infinities, integrated business case, and specific asks.

Earth Repair Manual

manual.warondisease.org/knowledge/appendix/google-ads-campaign-template / Prerequisites

Pre-Built Google Ads Campaign for Coalition Partners

A ready-to-load Google Ads campaign template for nonprofit partners running the 1% Treaty voter-acquisition channel through their existing Google Ad Grant.

Earth Repair Manual

manual.warondisease.org/knowledge/problem/fda-is-unsafe-and-ineffective / A Note on Blame

Your FDA Is Unsafe and Ineffective

A drug passes every safety test your species invented. It won't hurt you. Everyone agrees. You still can't have it for another 8.2 years (95% CI: 4.84 years-11.5 years). There is, however, no waiting list for dying. No one blocks that. The testing costs 44.1x (95% CI: 12.8x-210x) more than proven alternatives and excludes 86.1% of the patients who'll actually take it. For every 1 unit of harm prevented, the system creates 3,389 (95% CI: 1,811-5,734) through denied access. Here's how to fix it.

Earth Repair Manual

manual.warondisease.org/knowledge/appendix/dfda-impact-paper / Executive Summary

Ubiquitous Pragmatic Trial Impact Analysis: How to Prevent a Year of Death and Suffering for 84 Cents

Only 15 diseases/year (95% CI: 8 diseases/year-30 diseases/year) get their first treatment each year. With 6,650 diseases (95% CI: 5,700 diseases-8,232 diseases) lacking effective treatments, the backlog would take 443 years (95% CI: 255 years-841 years) to clear. Integrating pragmatic trials into standard healthcare increases trial capacity 12.3x (95% CI: 4.92x-50.8x), cutting that timeline from 443 years (95% CI: 255 years-841 years) to 36 years (95% CI: 8.15 years-106 years). The average untreated disease gets a treatment 212 years (95% CI: 124 years-398 years) earlier, saving 10.7 billion deaths (95% CI: 6.24 billion deaths-20.3 billion deaths) at $0.842 (95% CI: $0.264-$1.49) per year of healthy life saved.

Earth Repair Manual

manual.warondisease.org/knowledge/problem/genetic-slavery / How Hydrogen Learned to Worry (A 13.8 Billion Year Recap)

Genetic Slavery

Your government spends 604 (95% CI: 453-888) more on weapons than on curing disease, and you think that's a political problem. It's not. It's a hardware problem. You're running 200,000-year-old software optimized for hoarding rocks and fearing strangers, and you've given it nuclear weapons. This chapter is the owner's manual for the brain that's trying to kill you.

Search IC2EWD

Methodology, Parameters, and Calculations

The 1% Treaty: An Incentive-Compatible Approach to Ending War and Disease

The Optimal Budget Generator: A Causal Inference Protocol for Maximizing Median Health and Wealth Through Public Goods Funding

Join the International Campaign to End War and Disease

Pre-Built Google Ads Campaign for Coalition Partners

Your FDA Is Unsafe and Ineffective

Ubiquitous Pragmatic Trial Impact Analysis: How to Prevent a Year of Death and Suffering for 84 Cents

Genetic Slavery