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33 results for "clinical trials"
Let's trade one apocalypse out of humanity's 122-apocalypse mass-murder capacity for disease eradication in 36 years instead of 443.
Parameter definitions, formulas, uncertainty ranges, and data sources.
6,650 diseases (95% CI: 5,700 diseases-8,232 diseases) have zero FDA-approved treatments; at current trial capacity, exploring them takes ~443 years (95% CI: 255 years-841 years). Redirecting 1% of military spending scales capacity 12.3x (95% CI: 4.92x-50.8x), cutting the timeline to ~36 years (95% CI: 8.15 years-106 years) and preventing 10.7 billion deaths (95% CI: 6.24 billion deaths-20.3 billion deaths). At $0.00177 (95% CI: $0.000809-$0.00354)/DALY, 50.3kx (95% CI: 25.0kx-111.1kx) more cost-effective than the best existing interventions. The result holds across every specified adoption pathway.
The Optimal Budget Generator (OBG) uses causal inference, diminishing returns modeling, and cost-effectiveness evidence to determine optimal public goods funding levels that maximize two terminal general-welfare metrics: real after-tax median income growth and median healthy life years. For each spending category, OBG estimates an Optimal Spending Level (OSL) and produces a gap analysis showing where current government budgets are over- or underfunded relative to evidence-based benchmarks. The Budget Impact Score (BIS) measures confidence in each recommendation based on the quality of causal evidence.
Full case for getting organizations and individuals to endorse IC2EWD. Binary A/B choice, ICAN/ICBL precedent, post-WWII data, capital misallocation, fiduciary duty, margin flip, PCT engine, three infinities, integrated business case, and specific asks.
A ready-to-load Google Ads campaign template for nonprofit partners running the 1% Treaty voter-acquisition channel through their existing Google Ad Grant.
A drug passes every safety test your species invented. It won't hurt you. Everyone agrees. You still can't have it for another 8.2 years (95% CI: 4.84 years-11.5 years). There is, however, no waiting list for dying. No one blocks that. The testing costs 44.1x (95% CI: 12.8x-210x) more than proven alternatives and excludes 86.1% of the patients who'll actually take it. For every 1 unit of harm prevented, the system creates 3,389 (95% CI: 1,811-5,734) through denied access. Here's how to fix it.
Only 15 diseases/year (95% CI: 8 diseases/year-30 diseases/year) get their first treatment each year. With 6,650 diseases (95% CI: 5,700 diseases-8,232 diseases) lacking effective treatments, the backlog would take 443 years (95% CI: 255 years-841 years) to clear. Integrating pragmatic trials into standard healthcare increases trial capacity 12.3x (95% CI: 4.92x-50.8x), cutting that timeline from 443 years (95% CI: 255 years-841 years) to 36 years (95% CI: 8.15 years-106 years). The average untreated disease gets a treatment 212 years (95% CI: 124 years-398 years) earlier, saving 10.7 billion deaths (95% CI: 6.24 billion deaths-20.3 billion deaths) at $0.842 (95% CI: $0.264-$1.49) per year of healthy life saved.
Your government spends 604 (95% CI: 453-888) more on weapons than on curing disease, and you think that's a political problem. It's not. It's a hardware problem. You're running 200,000-year-old software optimized for hoarding rocks and fearing strangers, and you've given it nuclear weapons. This chapter is the owner's manual for the brain that's trying to kill you.
Redirecting 1% of global military spending (~$27.2 billion/year) to pragmatic clinical trials ($929/patient vs. $41,000/patient traditional) increases trial capacity 12.3x, cuttin...
Raffaella Petrini — Head of Government of Holy See (Vatican City). One job: redirect 1% of Holy See (Vatican City)'s military spending into pragmatic clinical trials. Overdue. Red...
Cho Jung-tai — Head of Government of Taiwan. One job: redirect 1% of Taiwan's military spending into pragmatic clinical trials. Overdue. Redirect 1% of Taiwan's military spending...
Daniel Risch — Head of Government of Liechtenstein. One job: redirect 1% of Liechtenstein's military spending into pragmatic clinical trials. Overdue. Redirect 1% of Liechtenstein...
Feleti Teo — Head of Government of Tuvalu. One job: redirect 1% of Tuvalu's military spending into pragmatic clinical trials. Overdue. Redirect 1% of Tuvalu's military spending ($...
Derog Gioura — Head of Government of Nauru. One job: redirect 1% of Nauru's military spending into pragmatic clinical trials. Overdue. Redirect 1% of Nauru's military spending ($8...
Hilda Heine — Head of Government of Marshall Islands. One job: redirect 1% of Marshall Islands's military spending into pragmatic clinical trials. Overdue. Redirect 1% of Marshall...
Surangel Whipps Jr. — Head of Government of Palau. One job: redirect 1% of Palau's military spending into pragmatic clinical trials. Overdue. Redirect 1% of Palau's military spend...
Wesley Simina — Head of Government of Micronesia. One job: redirect 1% of Micronesia's military spending into pragmatic clinical trials. Overdue. Redirect 1% of Micronesia's milit...
Taneti Maamau — Head of Government of Kiribati. One job: redirect 1% of Kiribati's military spending into pragmatic clinical trials. Overdue. Redirect 1% of Kiribati's military sp...
Fatafehi Fakafānua, 8th Lord Fakafānua — Head of Government of Tonga. One job: redirect 1% of Tonga's military spending into pragmatic clinical trials. Overdue. Redirect 1% of Ton...
Bob Loughman — Head of Government of Vanuatu. One job: redirect 1% of Vanuatu's military spending into pragmatic clinical trials. Overdue. Redirect 1% of Vanuatu's military spendi...
Roosevelt Skerrit — Head of Government of Dominica. One job: redirect 1% of Dominica's military spending into pragmatic clinical trials. Overdue. Redirect 1% of Dominica's militar...
Américo Ramos — Head of Government of São Tomé & Príncipe. One job: redirect 1% of São Tomé & Príncipe's military spending into pragmatic clinical trials. Overdue. Redirect 1% of...
Terrance Drew — Head of Government of St. Kitts & Nevis. One job: redirect 1% of St. Kitts & Nevis's military spending into pragmatic clinical trials. Overdue. Redirect 1% of St....
Fiamē Naomi Mataʻafa — Head of Government of Samoa. One job: redirect 1% of Samoa's military spending into pragmatic clinical trials. Overdue. Redirect 1% of Samoa's military spen...
Godwin Friday — Head of Government of Saint Vincent and the Grenadines. One job: redirect 1% of Saint Vincent and the Grenadines's military spending into pragmatic clinical trials...
Jeremiah Manele — Head of Government of Solomon Islands. One job: redirect 1% of Solomon Islands's military spending into pragmatic clinical trials. Overdue. Redirect 1% of Solomo...
Dickon Mitchell — Head of Government of Grenada. One job: redirect 1% of Grenada's military spending into pragmatic clinical trials. Overdue. Redirect 1% of Grenada's military spe...
Denise Bronzetti — Head of State of San Marino. One job: redirect 1% of San Marino's military spending into pragmatic clinical trials. Overdue. Redirect 1% of San Marino's militar...
Gaston Browne — Head of Government of Antigua & Barbuda. One job: redirect 1% of Antigua & Barbuda's military spending into pragmatic clinical trials. Overdue. Redirect 1% of Anti...
Azali Assoumani — Head of Government of Comoros. One job: redirect 1% of Comoros's military spending into pragmatic clinical trials. Overdue. Redirect 1% of Comoros's military spe...
Alix Didier Fils-Aimé — Head of Government of Haiti. One job: redirect 1% of Haiti's military spending into pragmatic clinical trials. Overdue. Redirect 1% of Haiti's military spe...
Philip J. Pierre — Head of Government of St. Lucia. One job: redirect 1% of St. Lucia's military spending into pragmatic clinical trials. Overdue. Redirect 1% of St. Lucia's milit...