Condition

Tracheal, bronchus, and lung cancer

Clinical trials and treatment information for Tracheal, bronchus, and lung cancer

3.3M
People Affected
200
Active Trials
1.1M
New Cases/Year
2M
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Osimertinib
90% Effectivenessβ€’ 95% Confidenceβ€’ 32% Safetyβ€’ 300 trialsβ€’ 30K participants
HIGH EvidencePoor ValueDose: 80 mg orally once daily
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Comparative Safety Scale(Higher is safer)

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MethπŸ’€
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Chemo☒️
Alcohol🍺
MorphineπŸ’Š
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32
DangerousModerateSafe

Time to Effect

6-8 weeks

Duration

Until disease progression or unacceptable toxicity

Response Rate

65%

Remission Rate

3%

Common Side Effects:

Diarrhea: 50%
Rash: 40%
Dry skin: 30%
Nail toxicity: 30%
Fatigue: 30%
Interstitial Lung Disease: 4%

Annual Cost of Care

Drug Cost

$185,000

Monitoring

$7,000

Side Effects

$5,000

Total Annual

$197,000

Cost-Effectiveness

POOR

QALYs Gained

0.81

ICER

$170,000/QALY

Cost per Remission

$6,566,667

Cost per Responder

$303,077

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+65%
Remission Rate
+3%
Common Side Effects
Diarrhea
+50%
Rash
+40%
Dry skin
+30%

Clinical Trial Phases:

Phase 3Phase 4
2
Alectinib
88% Effectivenessβ€’ 95% Confidenceβ€’ 32% Safetyβ€’ 200 trialsβ€’ 15K participants
HIGH EvidencePoor ValueDose: 600 mg orally twice daily
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Comparative Safety Scale(Higher is safer)

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Chemo☒️
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32
DangerousModerateSafe

Time to Effect

6-8 weeks

Duration

Until disease progression or unacceptable toxicity

Response Rate

75%

Remission Rate

4%

Common Side Effects:

Fatigue: 50%
Myalgia: 40%
Edema: 40%
Anemia: 30%
Constipation: 30%
Liver enzyme elevation: 20%
Bradycardia: 15%

Annual Cost of Care

Drug Cost

$185,000

Monitoring

$7,000

Side Effects

$5,000

Total Annual

$197,000

Cost-Effectiveness

POOR

QALYs Gained

0.76

ICER

$250,000/QALY

Cost per Remission

$4,925,000

Cost per Responder

$262,667

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+75%
Remission Rate
+4%
Common Side Effects
Fatigue
+50%
Myalgia
+40%
Edema
+40%

Clinical Trial Phases:

Phase 3Phase 4
3
Pembrolizumab
85% Effectivenessβ€’ 95% Confidenceβ€’ 35% Safetyβ€’ 500 trialsβ€’ 50K participants
HIGH EvidenceModerate ValueDose: 200 mg IV every 3 weeks or 400 mg IV every 6 weeks
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Comparative Safety Scale(Higher is safer)

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Chemo☒️
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35
DangerousModerateSafe

Time to Effect

2-4 months

Duration

Up to 2 years or until disease progression/unacceptable toxicity

Response Rate

35%

Remission Rate

5%

Common Side Effects:

Fatigue: 40%
Nausea: 20%
Diarrhea: 20%
Pruritus: 20%
Rash: 20%
Hypothyroidism: 15%
Pneumonitis (immune-related): 5%

Annual Cost of Care

Drug Cost

$180,000

Monitoring

$8,000

Side Effects

$10,000

Total Annual

$198,000

Cost-Effectiveness

MODERATE

QALYs Gained

0.46

ICER

$150,000/QALY

Cost per Remission

$3,960,000

Cost per Responder

$565,714

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+35%
Remission Rate
+5%
Common Side Effects
Fatigue
+40%
Nausea
+20%
Diarrhea
+20%

Clinical Trial Phases:

Phase 3Phase 4
4
Durvalumab
80% Effectivenessβ€’ 95% Confidenceβ€’ 35% Safetyβ€’ 300 trialsβ€’ 25K participants
HIGH EvidenceGood ValueDose: 10 mg/kg IV every 2 weeks or 1500 mg IV every 4 weeks
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Comparative Safety Scale(Higher is safer)

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Chemo☒️
Alcohol🍺
MorphineπŸ’Š
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35
DangerousModerateSafe

Time to Effect

2-4 months

Duration

Up to 1 year for Stage III consolidation, or until disease progression/unacceptable toxicity

Response Rate

30%

Remission Rate

5%

Common Side Effects:

Cough: 30%
Fatigue: 30%
Dyspnea: 20%
Radiation pneumonitis: 15%
Diarrhea: 15%
Rash: 10%
Hypothyroidism: 10%

Annual Cost of Care

Drug Cost

$140,000

Monitoring

$8,000

Side Effects

$10,000

Total Annual

$158,000

Cost-Effectiveness

GOOD

QALYs Gained

1.62

ICER

$60,000/QALY

Cost per Remission

$3,160,000

Cost per Responder

$526,667

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+30%
Remission Rate
+5%
Common Side Effects
Cough
+30%
Fatigue
+30%
Dyspnea
+20%

Clinical Trial Phases:

Phase 3Phase 4
5
Platinum-based Chemotherapy (Cisplatin + Pemetrexed)
60% Effectivenessβ€’ 90% Confidenceβ€’ 25% Safetyβ€’ 1000 trialsβ€’ 200K participants
HIGH EvidenceGood ValueDose: Cisplatin 75 mg/m2 IV Day 1; Pemetrexed 500 mg/m2 IV Day 1, every 3 weeks
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Comparative Safety Scale(Higher is safer)

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25
DangerousModerateSafe

Time to Effect

1-2 months

Duration

4-6 cycles (approx. 3-4 months)

Response Rate

30%

Remission Rate

1%

Common Side Effects:

Nausea/Vomiting: 90%
Fatigue: 80%
Neutropenia: 60%
Peripheral Neuropathy: 60%
Anemia: 50%
Thrombocytopenia: 20%
Nephrotoxicity: 30%

Annual Cost of Care

Drug Cost

$25,000

Monitoring

$6,000

Side Effects

$10,000

Total Annual

$41,000

Cost-Effectiveness

GOOD

QALYs Gained

0.25

Cost per Remission

$4,100,000

Cost per Responder

$136,667

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+30%
Remission Rate
+1%
Common Side Effects
Nausea/Vomiting
+90%
Fatigue
+80%
Neutropenia
+60%

Clinical Trial Phases:

Phase 3Phase 4
6
Carboplatin + Etoposide
55% Effectivenessβ€’ 90% Confidenceβ€’ 25% Safetyβ€’ 500 trialsβ€’ 50K participants
HIGH EvidenceGood ValueDose: Carboplatin AUC 5-6 IV Day 1; Etoposide 100-120 mg/m2 IV Days 1-3, every 3 weeks
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
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Chemo☒️
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MorphineπŸ’Š
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25
DangerousModerateSafe

Time to Effect

1-2 months

Duration

4-6 cycles (approx. 3-4 months)

Response Rate

65%

Remission Rate

10%

Common Side Effects:

Myelosuppression (Neutropenia, Thrombocytopenia, Anemia): 90%
Nausea/Vomiting: 80%
Fatigue: 70%
Alopecia: 70%
Peripheral Neuropathy: 20%
Mucositis: 20%

Annual Cost of Care

Drug Cost

$15,000

Monitoring

$5,000

Side Effects

$10,000

Total Annual

$30,000

Cost-Effectiveness

GOOD

QALYs Gained

0.15

Cost per Remission

$300,000

Cost per Responder

$46,154

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+55%
Response Rate
+65%
Remission Rate
+10%
Common Side Effects
Myelosuppression (Neutropenia, Thrombocytopenia, Anemia)
+90%
Nausea/Vomiting
+80%
Fatigue
+70%

Clinical Trial Phases:

Phase 3Phase 4