Procaine Penicillin G + Probenecid

Treatment for Syphilis

Typical Dosage: Procaine Penicillin G 2.4 million units IM daily + Probenecid 500 mg orally four times daily

Effectiveness
88%
Safety Score
65%
Clinical Trials
1
Participants
10K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe
Treatment Details
Dosage Range
Procaine Penicillin G 2.4 million units IM daily + Probenecid 500 mg orally four times daily
Time to Effect
2-4 weeks for CSF response
Treatment Duration
10-14 days
Evidence Quality
MODERATE
Number Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
20(Treat 20 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$400
Monitoring:$10,000
Side Effect Mgmt:$200
Total Annual:$10,600
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
ICER
$25,000/QALY
QALYs Gained
2.5
Outcome-Based Costs
Cost per Responder
$12,471
Cost per Remission
$12,471
Procaine Penicillin G + Probenecid Outcomes

for Syphilis

Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+85%
Remission Rate
+85%
Common Side Effects
Pain at injection site (Procaine Penicillin G)
+95%
Jarisch-Herxheimer reaction
+20%
Probenecid: Nausea, vomiting, rash
+10%
Hypersensitivity/Allergic reaction (mild)
+8%
Hypersensitivity/Allergic reaction (severe/anaphylaxis)
+1%

Sources:

nih.gov
croiconference.org
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

FIX IT
Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov

Completed Clinical Trials
1 completed trial for Procaine Penicillin G + Probenecid in Syphilis

Phase 1 Study of the Pharmacokinetics of Amoxicillin in Pregnancy

NCT05309928COMPLETEDPHASE1
View Study
13 participants
INTERVENTIONAL
Birmingham, United States
Started: Aug 29, 2023