Condition

Silicosis

Clinical trials and treatment information for Silicosis

234K
People Affected
50
Active Trials
2,341
New Cases/Year
10K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Oxygen Therapy
95% Effectiveness• 90% Confidence• 95% Safety• 1 trials• 50K participants
HIGH EvidenceExcellent ValueDose: 1-5 L/min to maintain SpO2 >90%
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
95
DangerousModerateSafe

Time to Effect

immediate

Duration

lifetime

Response Rate

95%

Remission Rate

0%

Common Side Effects:

Nasal dryness/irritation: 15%
Fire hazard (with misuse): 0.001%

Annual Cost of Care

Drug Cost

$2,000

Monitoring

$300

Side Effects

$50

Total Annual

$2,350

Cost-Effectiveness

EXCELLENT

QALYs Gained

1

Cost per Responder

$2,474

Treatment Outcomes
Primary Outcomes
Arterial Oxygen Partial Pressure (PaO2)55 mmHg
+18.18% (+10 mmHg)
Oxygen Saturation (SpO2)88%
+4.55% (+4%)
Dyspnea (mMRC Dyspnea Scale)mMRC score: 3/4
-33.33% (-1 point)
Mean Pulmonary Artery Pressure (PAP)35 mmHg
-14.29% (-5 mmHg)
Secondary Benefits
6-Minute Walk Distance (6MWD)250 meters
+20% (+50 meters)
Quality of Life (SGRQ total score)SGRQ total score: 60/100
-13.33% (-8 points)
Nocturnal Oxygen Saturation (Average SpO2)Average nocturnal SpO2: 85%
+8.24% (+7%)
Common Side Effects
Nasal dryness/irritation
+15%
Fire hazard (with misuse)
+0.001%
2
Antibiotics (e.g., Amoxicillin, Azithromycin)
90% Effectiveness• 90% Confidence• 70% Safety• 500 trials• 100K participants
HIGH EvidenceExcellent ValueDose: Amoxicillin 500mg TID, Azithromycin 500mg x1 then 250mg daily for 4 days
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

2-5 days

Duration

7-14 days per course

Response Rate

90%

Remission Rate

0%

Common Side Effects:

Diarrhea: 8%
Nausea: 3%
Rash: 2%

Annual Cost of Care

Drug Cost

$50

Monitoring

$200

Side Effects

$10

Total Annual

$260

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.08

Cost per Responder

$289

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+90%
Common Side Effects
Diarrhea
+8%
Nausea
+3%
Rash
+2%
3
Bronchodilators (e.g., Salbutamol, Tiotropium)
60% Effectiveness• 85% Confidence• 70% Safety• 150 trials• 25K participants
HIGH EvidenceGood ValueDose: Salbutamol 1-2 puffs q4-6h PRN, Tiotropium 1 inhalation daily
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

immediate to 2 weeks

Duration

lifetime

Response Rate

70%

Remission Rate

0%

Common Side Effects:

Tremor: 15%
Dry mouth: 10%
Palpitations: 7%

Annual Cost of Care

Drug Cost

$300

Monitoring

$150

Side Effects

$75

Total Annual

$525

Cost-Effectiveness

GOOD

QALYs Gained

0.08

Cost per Responder

$750

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+70%
Common Side Effects
Tremor
+15%
Dry mouth
+10%
Palpitations
+7%
4
Whole Lung Lavage
55% Effectiveness• 60% Confidence• 40% Safety• 1 trials• 90 participants
LOW EvidenceModerate Value
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
40
DangerousModerateSafe

Time to Effect

days to weeks

Duration

single procedure (may be repeated)

Response Rate

60%

Remission Rate

0%

Common Side Effects:

Hypoxemia: 15%
Fever: 10%
Pneumonia: 5%
Pneumothorax: 1%

Annual Cost of Care

Drug Cost

$0

Monitoring

$600

Side Effects

$1,000

Total Annual

$1,600

Cost-Effectiveness

MODERATE

QALYs Gained

0.8

Cost per Responder

$35,000

Treatment Outcomes
Primary Outcomes
Forced Vital Capacity (FVC)70% predicted (2.8 L)
+5% (+0.14 L)
Forced Expiratory Volume in 1 second (FEV1)65% predicted (2.1 L)
+4% (+0.08 L)
Dyspnea Score (mMRC)2/4
-25% (-0.5 points)
Diffusion Capacity for Carbon Monoxide (DLCO)60% predicted
+8% (+4.8% predicted)
Secondary Benefits
6-Minute Walk Test Distance350 meters
+10% (+35 meters)
Quality of Life (SGRQ Total Score)45 points
-15% (-6.75 points)
C-reactive protein (CRP)5 mg/L
-30% (-1.5 mg/L)
Common Side Effects
Hypoxemia
+15%
Fever
+10%
Pneumonia
+5%
5
Lung Transplantation
50% Effectiveness• 85% Confidence• 25% Safety• 2 trials• 10K participants
HIGH EvidencePoor Value
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
25
DangerousModerateSafe

Time to Effect

3-6 months post-surgery

Duration

lifetime

Response Rate

60%

Remission Rate

0%

Common Side Effects:

Rejection: 25%
Infection: 40%
Kidney dysfunction: 25%
Cancer: 5%

Annual Cost of Care

Drug Cost

$30,000

Monitoring

$15,000

Side Effects

$10,000

Total Annual

$55,000

Cost-Effectiveness

POOR

QALYs Gained

3

ICER

$250,000/QALY

Cost per Responder

$91,667

Treatment Outcomes
Primary Outcomes
Forced Expiratory Volume in 1 second (FEV1)0.8 L (25% predicted)
+150% (+1.2 L)
Six-Minute Walk Distance (6MWD)150 meters
+133.3% (+200 meters)
Dyspnea (mMRC Scale)mMRC score: 4/5
-75% (-3 points)
Arterial Partial Pressure of Oxygen (PaO2)55 mmHg
+36.4% (+20 mmHg)
Secondary Benefits
Quality of Life (SF-36 Physical Component Summary)SF-36 PCS score: 25
+80% (+20 points)
Body Mass Index (BMI)18 kg/m^2
+22.2% (+4 kg/m^2)
Annual Hospitalization Days (Respiratory)30 days/year
-90% (-27 days/year)
Common Side Effects
Rejection
+25%
Infection
+40%
Kidney dysfunction
+25%
6
Corticosteroids (e.g., Prednisone)
45% Effectiveness• 65% Confidence• 50% Safety• 25 trials• 400 participants
LOW EvidenceModerate ValueDose: 0.5-1 mg/kg/day, tapered
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
50
DangerousModerateSafe

Time to Effect

2-4 weeks

Duration

weeks to months (tapered)

Response Rate

40%

Remission Rate

0%

Common Side Effects:

Weight gain: 30%
Increased infection risk: 20%
Osteoporosis: 15%
Diabetes: 10%

Annual Cost of Care

Drug Cost

$50

Monitoring

$400

Side Effects

$1,250

Total Annual

$1,700

Cost-Effectiveness

MODERATE

QALYs Gained

0.15

Cost per Responder

$4,250

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+45%
Response Rate
+40%
Common Side Effects
Weight gain
+30%
Increased infection risk
+20%
Osteoporosis
+15%
7
Anti-fibrotic agents (e.g., Pirfenidone, Nintedanib)
25% Effectiveness• 30% Confidence• 35% Safety• 4 trials• 80 participants
VERY-LOW EvidencePoor ValueDose: Pirfenidone 2403mg/day, Nintedanib 150mg BID
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
35
DangerousModerateSafe

Time to Effect

6-12 months (to slow decline)

Duration

lifetime

Response Rate

15%

Remission Rate

0%

Common Side Effects:

Diarrhea: 65%
Nausea: 35%
Rash/Photosensitivity: 15%
Liver enzyme elevation: 7%

Annual Cost of Care

Drug Cost

$100,000

Monitoring

$750

Side Effects

$1,500

Total Annual

$102,250

Cost-Effectiveness

POOR

QALYs Gained

0.08

Cost per Responder

$681,667

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+25%
Response Rate
+15%
Common Side Effects
Diarrhea
+65%
Nausea
+35%
Rash/Photosensitivity
+15%