Praziquantel
Treatment for Schistosomiasis
Typical Dosage: 40 mg/kg body weight, single oral dose
Effectiveness
90%
Safety Score
75%
Clinical Trials
38
Participants
500K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
75
DangerousModerateSafe
Treatment Details
Dosage Range
40 mg/kg body weight, single oral dose
Time to Effect
Rapid, days to weeks for symptom improvement
Treatment Duration
Single dose
Evidence Quality
HIGHNumber Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
1000(Treat 1000 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$5
Monitoring:$40
Side Effect Mgmt:$10
Total Annual:$55
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$500/QALY
QALYs Gained
1
Outcome-Based Costs
Cost per Responder
$57.89
Cost per Remission
$68.75
Comparison vs No Treatment
Cost Difference
+$55/year
More expensive
QALY Difference
+1.00 QALYs
Better outcomes
Dominance
No dominance
Prescription Access Economics
Annual Societal Loss per Patient
$188
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$125/year
Time Cost
$40/year
Travel + wait time
Insurance Admin Cost
$20/year
Prior auth, claims
Rx Price
$5/year
Potential OTC Price
$2/year
Estimated if OTC available
Early Treatment Benefit
+0.10 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOWMissed Diagnosis Risk
MODERATEPraziquantel Outcomes
for Schistosomiasis
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+95%
Remission Rate
+80%
Common Side Effects
Abdominal pain
+25%
Headache
+20%
Dizziness
+15%
Nausea
+10%
Fever
+8%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
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Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
15 completed trials for Praziquantel in Schistosomiasis
L-PZQ ODT in Schistosoma Infected Children
NCT03845140COMPLETEDPHASE3
288 participants
INTERVENTIONAL
Abidjan, Côte d’Ivoire +1 more
Started: Sep 2, 2019
Repeated Doses of Praziquantel in Schistosomiasis Treatment (RePST)
NCT02868385COMPLETEDPHASE3
167 participants
INTERVENTIONAL
Abidjan, Côte d’Ivoire
Started: Oct 1, 2018
Praziquantel-Pharmacokinetic Study
NCT01288872COMPLETEDPHASE1
47 participants
INTERVENTIONAL
Muntinlupa City, Philippines
Started: Jan 1, 2012
Schistosoma Haematobium Infections and Praziquantel
NCT01558336COMPLETEDPHASE3
520 participants
INTERVENTIONAL
Al Salamania, Sudan
Started: Aug 1, 2008
An Open Label Dose Finding Safety and Efficacy in Children and Infants Infected With Schistosomiasis (S.Mansoni)
NCT02806232COMPLETEDPHASE2
444 participants
INTERVENTIONAL
Darmstadt, Germany
Started: Jun 12, 2016
Praziquantel in Children Under Age 4
NCT03640377COMPLETEDPHASE2
354 participants
INTERVENTIONAL
Entebbe, Uganda +1 more
Started: Feb 1, 2021
Schistosoma Mansoni Morbidity in Children Aged 1-5 Years
NCT01901484COMPLETEDPHASE2
800 participants
INTERVENTIONAL
Kampala, Uganda
Started: Dec 1, 2012
Effect of Schistosomiasis Mansoni on HIV Susceptibility and Female Genital Immunology
NCT02878564COMPLETEDPHASE4
34 participants
INTERVENTIONAL
Entebbe, Uganda
Started: Mar 1, 2016
S. Japonicum and Pregnancy Outcomes
NCT00486863COMPLETEDPHASE2
370 participants
INTERVENTIONAL
Muntinlupa City, Philippines
Started: Aug 1, 2007
The Effect of Praziquantel Treatment on Schistosoma Mansoni Morbidity and re-Infection Along Lake Victoria, Uganda
NCT00215267COMPLETEDNA
540 participants
INTERVENTIONAL
Busuyi Parish, Uganda
Started: Sep 1, 2005
Treatment of Female Genital Schistosomiasis (FGS) With Praziquantel: A Proof-of-Concept Study
NCT04115072COMPLETEDPHASE2, PHASE3
116 participants
INTERVENTIONAL
Ambanja, Madagascar
Started: Sep 3, 2019
Evaluation of Praziquantel Dosage for Treatment of Schistosomiasis in Brazil
NCT00403611COMPLETEDPHASE4
196 participants
INTERVENTIONAL
Started: Mar 1, 2006
Arachidonic Acid Treatment Against Schistosomiasis Infection in Children
NCT02144389COMPLETEDNA
335 participants
INTERVENTIONAL
Shebin El-Kom, Egypt +2 more
Started: Jan 1, 2013
Safety and Efficacy of Drug Combinations Against Schistosomiasis
NCT01050374COMPLETEDNA
650 participants
INTERVENTIONAL
Kampala, Uganda
Started: Oct 1, 2007
Schistosoma Mansoni in Mwanza Region, Tanzania
NCT02162875COMPLETEDNA
37.5K participants
INTERVENTIONAL
Mwanza, Tanzania
Started: Mar 1, 2011
Showing 20 of 38 total trials