Condition

Schistosomiasis

Clinical trials and treatment information for Schistosomiasis

151.4M
People Affected
50
Active Trials
12M
New Cases/Year
13K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Praziquantel
90% Effectiveness• 95% Confidence• 75% Safety• 38 trials• 500K participants
HIGH EvidenceExcellent ValueDose: 40 mg/kg body weight, single oral dose
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
75
DangerousModerateSafe

Time to Effect

Rapid, days to weeks for symptom improvement

Duration

Single dose

Response Rate

95%

Remission Rate

80%

Number Needed to Treat (NNT)

3

Number Needed to Harm (NNH)

1000

Common Side Effects:

Abdominal pain: 25%
Headache: 20%
Dizziness: 15%
Nausea: 10%
Fever: 8%

Annual Cost of Care

Drug Cost

$5

Monitoring

$40

Side Effects

$10

Total Annual

$55

Cost-Effectiveness

EXCELLENT

QALYs Gained

1

ICER

$500/QALY

Cost per Remission

$68.75

Cost per Responder

$57.89

Treatment Outcomes
Primary Outcomes
Schistosome Egg Count (S. mansoni, EPG)400 eggs/gram (EPG)
-95% (-380 EPG)
Abdominal Pain Severity (NRS 0-10)6/10
-65% (-3.9 points)
Hematuria Severity (RBC/HPF in urine)70 RBC/HPF
-80% (-56 RBC/HPF)
Spleen Size (cm below costal margin)3 cm below costal margin
-60% (-1.8 cm)
Secondary Benefits
Hemoglobin Level10.5 g/dL
+14.3% (+1.5 g/dL)
Schistosomiasis-Specific Quality of Life Score (0-100)50/100
+20% (+10 points)
Fatigue Severity Scale (FSS 1-7)5.5/7
-36.4% (-2.0 points)
Common Side Effects
Abdominal pain
+25%
Headache
+20%
Dizziness
+15%

Clinical Trial Phases:

Phase 4
2
Oxamniquine
90% Effectiveness• 90% Confidence• 68% Safety• 100 trials• 50K participants
HIGH EvidenceExcellent ValueDose: 15-20 mg/kg body weight, single oral dose
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
68
DangerousModerateSafe

Time to Effect

Rapid, days to weeks for symptom improvement

Duration

Single dose

Response Rate

95%

Remission Rate

80%

Number Needed to Treat (NNT)

3

Number Needed to Harm (NNH)

100

Common Side Effects:

Dizziness: 30%
Nausea: 15%
Headache: 10%
Abdominal pain: 8%
Convulsions (rare): 0.5%

Annual Cost of Care

Drug Cost

$10

Monitoring

$40

Side Effects

$20

Total Annual

$70

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.9

ICER

$600/QALY

Cost per Remission

$87.5

Cost per Responder

$73.68

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+95%
Remission Rate
+80%
Common Side Effects
Dizziness
+30%
Nausea
+15%
Headache
+10%

Clinical Trial Phases:

Phase 4
3
Tribendimidine
75% Effectiveness• 75% Confidence• 72% Safety• 20 trials• 5K participants
MODERATE EvidenceExcellent ValueDose: 200-400 mg single oral dose
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
72
DangerousModerateSafe

Time to Effect

Rapid, days to weeks

Duration

Single dose

Response Rate

85%

Remission Rate

70%

Number Needed to Treat (NNT)

4

Number Needed to Harm (NNH)

150

Common Side Effects:

Abdominal discomfort: 15%
Nausea: 10%
Dizziness: 8%
Headache: 7%

Annual Cost of Care

Drug Cost

$7

Monitoring

$40

Side Effects

$15

Total Annual

$62

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.9

ICER

$700/QALY

Cost per Remission

$88.57

Cost per Responder

$72.94

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+85%
Remission Rate
+70%
Common Side Effects
Abdominal discomfort
+15%
Nausea
+10%
Dizziness
+8%

Clinical Trial Phases:

Phase 4
4
Metrifonate
65% Effectiveness• 70% Confidence• 60% Safety• 50 trials• 10K participants
MODERATE EvidenceExcellent ValueDose: 7.5-10 mg/kg body weight, three doses at 2-week intervals
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe

Time to Effect

Rapid for parasite killing, weeks-months for symptom improvement

Duration

3 doses over 4 weeks

Response Rate

75%

Remission Rate

60%

Number Needed to Treat (NNT)

4

Number Needed to Harm (NNH)

50

Common Side Effects:

Abdominal pain: 30%
Nausea: 25%
Dizziness: 20%
Fatigue: 18%
Sweating: 7%

Annual Cost of Care

Drug Cost

$15

Monitoring

$40

Side Effects

$30

Total Annual

$85

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.7

ICER

$800/QALY

Cost per Remission

$141.67

Cost per Responder

$113.33

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+65%
Response Rate
+75%
Remission Rate
+60%
Common Side Effects
Abdominal pain
+30%
Nausea
+25%
Dizziness
+20%

Clinical Trial Phases:

Phase 4