Methotrexate
Treatment for Rheumatoid arthritis
Typical Dosage: 7.5-25 mg once weekly
Effectiveness
75%
Safety Score
30%
Clinical Trials
693
Participants
150K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
30
DangerousModerateSafe
Treatment Details
Dosage Range
7.5-25 mg once weekly
Time to Effect
4-6 weeks
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
10(Treat 10 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$100
Monitoring:$1,200
Side Effect Mgmt:$300
Total Annual:$1,600
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$15,000/QALY
QALYs Gained
1
Outcome-Based Costs
Cost per Responder
$2,461.54
Cost per Remission
$8,000
Methotrexate Outcomes
for Rheumatoid arthritis
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+65%
Remission Rate
+20%
Common Side Effects
Nausea
+30%
Fatigue
+20%
Hair thinning
+10%
Elevated liver enzymes
+15%
Mouth sores (stomatitis)
+10%
Myelosuppression
+5%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
5 active trials recruiting for Methotrexate in Rheumatoid arthritis
Effect of MTX Discontinuation on Shingrix Response in RA
NCT06574594RECRUITINGNA
110 participants
INTERVENTIONAL
Seoul, South Korea
Started: Aug 22, 2024
MethMax Trial: MAXimising the METHotrexate Therapy Potential in Patients with Active Rheumatoid Arthritis
NCT06649136RECRUITINGPHASE4
182 participants
INTERVENTIONAL
Vienna, Austria
Started: Aug 12, 2024
Methotrexate in Patients with Early Rheumatoid Arthritis
NCT05353829ACTIVE NOT RECRUITINGPHASE4
212 participants
INTERVENTIONAL
Eskilstuna, Sweden +12 more
Started: Apr 28, 2022
Methotrexate Combined With Tofacitinib in Rheumatoid Arthritis
NCT06301373RECRUITINGNA
130 participants
INTERVENTIONAL
Foshan, China +4 more
Started: Sep 1, 2024
Natrunix in Combination With Methotrexate for Rheumatoid Arthritis Treatment
NCT06590090NOT YET RECRUITINGPHASE2
108 participants
INTERVENTIONAL
Started: Jul 15, 2026
Completed Clinical Trials
10 completed trials for Methotrexate in Rheumatoid arthritis
Study of the Efficacy and Safety of BCD-089 in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis
NCT04227366COMPLETEDPHASE3
154 participants
INTERVENTIONAL
Moscow, Russia
Started: Nov 19, 2019
PoC in Rheumatoid Arthritis With Methotrexate
NCT00605735COMPLETEDPHASE2
121 participants
INTERVENTIONAL
Palm Desert, United States +27 more
Started: Mar 1, 2008
Methotrexate Polyglutamate Levels as a Marker for the Clinical Outcome in the Treatment of Rheumatoid Arthritis
NCT00695188COMPLETEDPHASE4
19 participants
INTERVENTIONAL
Vienna, Austria +1 more
Started: May 1, 2008
Study of Two Different Starting Doses of Methotrexate When Starting Treatment in Rheumatoid Arthritis
NCT01404429COMPLETEDPHASE4
100 participants
INTERVENTIONAL
Chandigarh, India
Started: May 1, 2011
Comparison of Compliance and Evolution of Functional Capacity of Patients With Rheumatoid Arthritis Treated by Methotrexate Either by Auto-injector or by Conventional Sub-cutaneous Syringe
NCT02553018COMPLETEDPHASE3
278 participants
INTERVENTIONAL
Brest, France +1 more
Started: Sep 1, 2015
Efficacy and Safety of TAK-783 in Subjects With Rheumatoid Arthritis
NCT00760968COMPLETEDPHASE2
224 participants
INTERVENTIONAL
Brno-Bohunice, Czechia +24 more
Started: Aug 1, 2007
Study Comparing Etanercept in Combination With Methotrexate in Subjects With Rheumatoid Arthritis
NCT00565409COMPLETEDPHASE4
834 participants
INTERVENTIONAL
Campsie, Australia +80 more
Started: Mar 1, 2008
ACP-196 Versus Placebo in Subjects With Rheumatoid Arthritis on Background Methotrexate
NCT02387762COMPLETEDPHASE2
31 participants
INTERVENTIONAL
Anniston, United States +16 more
Started: Apr 1, 2015
A Comparison of Methotrexate Alone or Combined to Infliximab or to Pulse Methylprednisolone in Early Rheumatoid Arthritis: A Magnetic Resonance Imaging Study
NCT00396747COMPLETEDPHASE4
45 participants
INTERVENTIONAL
Brussels, Belgium
Started: Jun 1, 2003
Paroxetine Safety and Efficacy in Rheumatoid Arthritis
NCT06231745COMPLETEDPHASE3
100 participants
INTERVENTIONAL
Damietta, Egypt
Started: Jan 31, 2024
Showing 20 of 698 total trials