Pregabalin
Treatment for Restless Legs Syndrome
Typical Dosage: 150-450 mg daily
Effectiveness
78%
Safety Score
62%
Clinical Trials
7
Participants
4K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
62
DangerousModerateSafe
Treatment Details
Dosage Range
150-450 mg daily
Time to Effect
1-2 weeks
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$360
Monitoring:$300
Side Effect Mgmt:$50
Total Annual:$710
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$25,000/QALY
QALYs Gained
0.25
Outcome-Based Costs
Cost per Responder
$979
Cost per Remission
$2,367
Comparison vs Pramipexole
Cost Difference
+$180/year
More expensive
QALY Difference
+0.05 QALYs
Better outcomes
Dominance
No dominance
Pregabalin Outcomes
for Restless Legs Syndrome
Efficacy Outcomes
Overall Effectiveness
+78%
Response Rate
+72%
Remission Rate
+30%
Common Side Effects
Dizziness
+25%
Somnolence
+20%
Weight gain
+7%
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
1 active trial recruiting for Pregabalin in Restless Legs Syndrome
Quality Improvement and Practice Based Research in Neurology Using the EMR
NCT02670161ENROLLING BY INVITATIONPHASE4
3.3K participants
INTERVENTIONAL
Evanston, United States
Started: May 1, 2016
Completed Clinical Trials
4 completed trials for Pregabalin in Restless Legs Syndrome
Lyrica Dose Response Study With Restless Legs Syndrome (RLS) Patients
NCT00676403COMPLETEDPHASE2
137 participants
INTERVENTIONAL
Tuscaloosa, United States +24 more
Started: Apr 1, 2008
RCT for Pregabalin in Restless Legs Syndrome in South Korea
NCT04161027COMPLETEDPHASE3
116 participants
INTERVENTIONAL
Seoul, South Korea
Started: Feb 24, 2020
Polysomnography Study Of Pregabalin And Pramipexole Versus Placebo In Patients With Restless Legs Syndrome And Associated Sleep Disturbance
NCT00991276COMPLETEDPHASE3
85 participants
INTERVENTIONAL
Jasper, United States +40 more
Started: Dec 1, 2009
Long Term Study Of Pregabalin In Idiopathic Restless Legs Syndrome Patients
NCT00806026COMPLETEDPHASE3
731 participants
INTERVENTIONAL
Birmingham, United States +109 more
Started: Dec 1, 2008