Condition

Pyoderma

Clinical trials and treatment information for Pyoderma

34.4M
People Affected
50
Active Trials
100M
New Cases/Year
46K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Infliximab
90% Effectiveness• 90% Confidence• 48% Safety• 1 trials• 500 participants
HIGH EvidenceExcellent ValueDose: 5 mg/kg IV at weeks 0, 2, 6, then every 8 weeks
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Comparative Safety Scale(Higher is safer)

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48
DangerousModerateSafe

Time to Effect

2-4 weeks

Duration

Long-term (induction then maintenance)

Response Rate

85%

Remission Rate

60%

Common Side Effects:

Infusion reactions: 10%
Upper respiratory tract infection: 25%
Headache: 15%
Nausea: 10%
Serious infections (e.g., TB reactivation): 3%

Annual Cost of Care

Drug Cost

$45,000

Monitoring

$2,000

Side Effects

$500

Total Annual

$47,500

Cost-Effectiveness

EXCELLENT

QALYs Gained

1.2

ICER

$39,583.33/QALY

Cost per Remission

$79,166.67

Cost per Responder

$55,882.35

Treatment Outcomes
Primary Outcomes
Pyoderma Gangrenosum Lesion Activity (PGA Score)PGA Score: 4/5 (severe disease)
-50% (-2 points (from severe to moderate disease activity))
Pain Visual Analog Scale (VAS)VAS Score: 70/100 (severe pain)
-50% (-35 points (from 70 to 35))
Pyoderma Gangrenosum Ulcer AreaAverage Ulcer Area: 20 cm²
-60% (-12 cm²)
Secondary Benefits
Dermatology Life Quality Index (DLQI)DLQI Score: 18/30 (very large effect on QoL)
-45% (-8 points (from 18 to 10))
Oral Corticosteroid DosePrednisone Equivalent: 20 mg/day
-60% (-12 mg/day (from 20 to 8 mg/day))
C-Reactive Protein (CRP)CRP: 30 mg/L (elevated)
-70% (-21 mg/L (from 30 to 9 mg/L))
Common Side Effects
Infusion reactions
+10%
Upper respiratory tract infection
+25%
Headache
+15%

Clinical Trial Phases:

Phase 3Phase 4
2
Adalimumab
85% Effectiveness• 85% Confidence• 48% Safety• 4 trials• 500 participants
HIGH EvidenceExcellent ValueDose: 80 mg SC initial, then 40 mg SC every other week
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Comparative Safety Scale(Higher is safer)

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48
DangerousModerateSafe

Time to Effect

4-8 weeks

Duration

Long-term (induction then maintenance)

Response Rate

75%

Remission Rate

50%

Common Side Effects:

Injection site reactions: 15%
Upper respiratory tract infection: 20%
Headache: 12%
Serious infections (e.g., TB reactivation): 2%

Annual Cost of Care

Drug Cost

$45,000

Monitoring

$1,000

Side Effects

$500

Total Annual

$46,500

Cost-Effectiveness

EXCELLENT

QALYs Gained

1.1

ICER

$42,272.73/QALY

Cost per Remission

$93,000

Cost per Responder

$62,000

Treatment Outcomes
Primary Outcomes
Pyoderma Gangrenosum Area and Severity Index (PGA) Score9/12 points
-60% (-5.4 points)
Average Number of Active Ulcers/Lesions3 active ulcers
-67% (-2 ulcers)
NRS Pain Score7/10 points
-50% (-3.5 points)
Total Ulcer Area15 cm²
-70% (-10.5 cm²)
Secondary Benefits
Dermatology Life Quality Index (DLQI) Score18/30 points
-50% (-9 points)
Systemic Corticosteroid Dose20 mg/day Prednisone equivalent
-75% (-15 mg/day)
C-Reactive Protein (CRP)15 mg/L
-60% (-9 mg/L)
Common Side Effects
Injection site reactions
+15%
Upper respiratory tract infection
+20%
Headache
+12%

Clinical Trial Phases:

Phase 3Phase 4
3
Prednisone (Oral)
80% Effectiveness• 85% Confidence• 38% Safety• 50 trials• 1K participants
HIGH EvidenceExcellent ValueDose: 0.5-2 mg/kg/day, tapered
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Comparative Safety Scale(Higher is safer)

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38
DangerousModerateSafe

Time to Effect

1-2 weeks

Duration

Initial high dose for weeks, then taper over months

Response Rate

70%

Remission Rate

40%

Common Side Effects:

Weight gain: 70%
Hyperglycemia: 40%
Hypertension: 30%
Mood changes: 25%
Infections: 15%
Osteoporosis (long-term): 10%

Annual Cost of Care

Drug Cost

$50

Monitoring

$500

Side Effects

$200

Total Annual

$750

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.8

ICER

$937.5/QALY

Cost per Remission

$1,875

Cost per Responder

$1,071.43

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+70%
Remission Rate
+40%
Common Side Effects
Weight gain
+70%
Hyperglycemia
+40%
Hypertension
+30%

Clinical Trial Phases:

Phase 4
4
Cyclosporine (Oral)
75% Effectiveness• 80% Confidence• 38% Safety• 20 trials• 500 participants
MODERATE EvidenceExcellent ValueDose: 3-5 mg/kg/day
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Comparative Safety Scale(Higher is safer)

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38
DangerousModerateSafe

Time to Effect

2-4 weeks

Duration

Months to years

Response Rate

60%

Remission Rate

30%

Common Side Effects:

Nephrotoxicity: 30%
Hypertension: 50%
Hirsutism: 25%
Gingival hyperplasia: 20%
Tremor: 15%
Infections: 10%

Annual Cost of Care

Drug Cost

$1,000

Monitoring

$1,500

Side Effects

$300

Total Annual

$2,800

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.7

ICER

$4,000/QALY

Cost per Remission

$9,333.33

Cost per Responder

$4,666.67

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+60%
Remission Rate
+30%
Common Side Effects
Nephrotoxicity
+30%
Hypertension
+50%
Hirsutism
+25%

Clinical Trial Phases:

Phase 4
5
Mycophenolate Mofetil (MMF)
70% Effectiveness• 75% Confidence• 38% Safety• 15 trials• 400 participants
MODERATE EvidenceExcellent ValueDose: 1-3 g/day, orally
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Comparative Safety Scale(Higher is safer)

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Meth💀
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Morphine💊
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38
DangerousModerateSafe

Time to Effect

4-8 weeks

Duration

Months to years

Response Rate

50%

Remission Rate

30%

Common Side Effects:

Diarrhea: 35%
Nausea: 25%
Vomiting: 15%
Leukopenia: 20%
Anemia: 10%
Infections: 10%

Annual Cost of Care

Drug Cost

$500

Monitoring

$750

Side Effects

$150

Total Annual

$1,400

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.6

ICER

$2,333.33/QALY

Cost per Remission

$4,666.67

Cost per Responder

$2,800

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+50%
Remission Rate
+30%
Common Side Effects
Diarrhea
+35%
Nausea
+25%
Vomiting
+15%

Clinical Trial Phases:

Phase 4
6
Topical Corticosteroids (e.g., Clobetasol) / Topical Tacrolimus
65% Effectiveness• 70% Confidence• 70% Safety• 15 trials• 300 participants
MODERATE EvidenceExcellent ValueDose: Apply 1-2 times daily
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Comparative Safety Scale(Higher is safer)

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70
DangerousModerateSafe

Time to Effect

2-4 weeks

Duration

Weeks to months, often intermittent long-term

Response Rate

50%

Remission Rate

20%

Common Side Effects:

Skin atrophy: 15%
Telangiectasias: 10%
Burning/Stinging: 5%
Irritation: 5%

Annual Cost of Care

Drug Cost

$800

Monitoring

$200

Side Effects

$50

Total Annual

$1,050

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.3

ICER

$3,500/QALY

Cost per Remission

$5,250

Cost per Responder

$2,100

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+65%
Response Rate
+50%
Remission Rate
+20%
Common Side Effects
Skin atrophy
+15%
Telangiectasias
+10%
Burning/Stinging
+5%

Clinical Trial Phases:

Phase 4