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Pregabalin
Treatment for Peripheral Neuropathy
Typical Dosage: 150-600 mg daily in 2-3 divided doses
Effectiveness
80%
Safety Score
58%
Clinical Trials
154
Participants
20K
Comparative Safety Scale(Higher is safer)
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Meth💀
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Morphine💊
Antibiotics💉
Tylenol💊
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Water💧
58
DangerousModerateSafe
Treatment Details
Dosage Range
150-600 mg daily in 2-3 divided doses
Time to Effect
1 week
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
8(Treat 8 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
8(Treat 8 patients to see 1 additional serious adverse event)
Confidence Score
88%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$400
Monitoring:$250
Side Effect Mgmt:$100
Total Annual:$750
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODICER
$65,000/QALY
QALYs Gained
0.07
Outcome-Based Costs
Cost per Responder
$1,500
Cost per Remission
$9,375
Comparison vs Gabapentin
Cost Difference
+$220/year
More expensive
QALY Difference
+0.01 QALYs
Better outcomes
Dominance
No dominance
Pregabalin Outcomes
for Peripheral Neuropathy
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+50%
Remission Rate
+8%
Common Side Effects
Dizziness
+25%
Somnolence
+25%
Peripheral edema
+8%
Weight gain
+7%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
1 active trial recruiting for Pregabalin in Peripheral Neuropathy
SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy.
NCT06614322RECRUITINGPHASE2
190 participants
INTERVENTIONAL
Boston, United States +6 more
Started: Jan 29, 2026
Completed Clinical Trials
16 completed trials for Pregabalin in Peripheral Neuropathy
PK and Food Effect of Pregabalin Study After Dosing in Healthy Male Volunteers
NCT02783638COMPLETEDPHASE1
64 participants
INTERVENTIONAL
Jeonju, South Korea
Started: Jan 1, 2016
Safety of Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy
NCT00159731COMPLETEDPHASE4
160 participants
INTERVENTIONAL
Hot Springs, United States +28 more
Started: Jan 1, 2005
Effects of Pregabalin, Duloxetine & Amitriptyline on Pain & Sleep
NCT00370656COMPLETEDPHASE2, PHASE3
90 participants
INTERVENTIONAL
Bournemouth, United Kingdom +2 more
Started: Feb 1, 2007
Efficacy and Safety Study of Pregabalin in the Treatment of Pain on Walking in Patients With Diabetic Peripheral Neuropathy (DPN)
NCT01474772COMPLETEDPHASE3
217 participants
INTERVENTIONAL
Goodyear, United States +44 more
Started: Oct 1, 2011
Pregabalin in Preventing Acute Pain Syndrome in Patients Receiving Paclitaxel
NCT01637077COMPLETEDPHASE2
46 participants
INTERVENTIONAL
Wichita, United States +5 more
Started: Jan 1, 2012
Pregabalin vs Placebo in Treatment of Neuropathic Pain Associated With Diabetic Peripheral Neuropathy
NCT00143156COMPLETEDPHASE3
450 participants
INTERVENTIONAL
Tuscaloosa, United States +53 more
Started: Mar 1, 2005
Open Label Safety And Efficacy Study Of Pregabalin In Subjects With Nerve Pain Asociated With Human Immunodeficiency Virus (HIV) Neuropathy
NCT00264875COMPLETEDPHASE3
220 participants
INTERVENTIONAL
Phoenix, United States +36 more
Started: Feb 1, 2006
Study Of Pregabalin (Lyrica) In Patients With Painful Diabetic Peripheral Neuropathy
NCT01057693COMPLETEDPHASE3
633 participants
INTERVENTIONAL
Birmingham, United States +171 more
Started: Mar 31, 2010
Evaluation of Efficacy and Safety of VX-548 for Painful Diabetic Peripheral Neuropathy (DPN)
NCT05660538COMPLETEDPHASE2
194 participants
INTERVENTIONAL
Anniston, United States +49 more
Started: Dec 20, 2022
Randomized, Double-Blind, Multicenter, Placebo-Controlled Study Of Pregabalin For Pain Associated With Diabetic Peripheral Neuropathy
NCT00553475COMPLETEDPHASE3
314 participants
INTERVENTIONAL
Nagoya, Japan +48 more
Started: Oct 1, 2007
The Effect of Pregabalin on Pain Related to Walking in Patients With Diabetic Peripheral Neuropathy
NCT02927951COMPLETEDPHASE3
44 participants
INTERVENTIONAL
Norfolk, United States +1 more
Started: Jan 1, 2011
Pregabalin Peripheral Neuropathic Pain Study
NCT00141219COMPLETEDPHASE3
241 participants
INTERVENTIONAL
Sungnam-si, South Korea +9 more
Started: Dec 1, 2005
Pregabalin and Alpha-lipoic Acid Combination Versus Each Monotherapy in Patients With Diabetic Peripheral Neuropathy
NCT04846673COMPLETEDPHASE4
151 participants
INTERVENTIONAL
Busan, South Korea +13 more
Started: May 14, 2021
Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy
NCT00159679COMPLETEDPHASE4
167 participants
INTERVENTIONAL
Hot Springs, United States +29 more
Started: Sep 1, 2004
Thymoquinone as an add-on Therapy for the Management of Patients With Diabetic Peripheral Neuropathy
NCT07313111COMPLETEDPHASE4
50 participants
INTERVENTIONAL
Erbil, Iraq
Started: Jul 1, 2024
A Long-Term Study To Evaluate Safety And Efficacy Of Pregabalin For Pain Associated With Diabetic Peripheral Neuropathy
NCT00553280COMPLETEDPHASE3
123 participants
INTERVENTIONAL
Nagoya, Japan +26 more
Started: Feb 1, 2008
Showing 20 of 161 total trials