Deep Brain Stimulation (DBS)

Treatment for Parkinson's disease

Typical Dosage: Programmable stimulation parameters

Effectiveness

88%

Safety Score

45%

Clinical Trials

336

Participants

20K

Comparative Safety Scale(Higher is safer)

Cyanide☠️

Meth💀

Cigarettes🚬

Chemo☢️

Alcohol🍺

Morphine💊

Antibiotics💉

Tylenol💊

Exercise🏃

Water💧

DangerousModerateSafe

Treatment Details

Dosage Range

Programmable stimulation parameters

Time to Effect

Days to weeks (post-activation)

Treatment Duration

Lifetime (with battery replacement every 3-5 years)

Evidence Quality

HIGH

Number Needed to Treat (NNT)

3(Treat 3 patients to see 1 additional successful outcome)

Number Needed to Harm (NNH)

30(Treat 30 patients to see 1 additional serious adverse event)

Confidence Score

90%confidence in effectiveness data

Health Economics

Annual Cost of Care

Drug Cost:$0

Monitoring:$6,000

Side Effect Mgmt:$500

Total Annual:$14,000

Cost-Effectiveness Analysis

Cost-Effectiveness Rating

GOOD

ICER

$90,000/QALY

QALYs Gained

0.15

Outcome-Based Costs

Cost per Responder

$17,500

Comparison vs Optimal Medical Therapy

Cost Difference

+$18,000/year

More expensive

QALY Difference

+0.15 QALYs

Better outcomes

Dominance

No dominance

Deep Brain Stimulation (DBS) Outcomes

for Parkinson's disease

Efficacy Outcomes

Overall Effectiveness

+88%

Response Rate

+80%

Common Side Effects

Infection

+7%

Intracranial hemorrhage

+3%

Device-related complications

+10%

Speech/swallowing issues

+7%

Sources:

bmj.com

mdpi.com

researchgate.net

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials

5 active trials recruiting for Deep Brain Stimulation (DBS) in Parkinson's disease

Registry of Deep Brain Stimulation With the VERCISE™ System: Vercise DBS Registry

NCT02071134RECRUITING

View Study

1.5K participants

OBSERVATIONAL

Aliso Viejo, United States +83 more

Started: Mar 4, 2014

Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

NCT06911229RECRUITINGNA

View Study

60 participants

INTERVENTIONAL

Gainesville, United States

Started: Aug 1, 2025

Coordinated Reset Deep Brain Stimulation for Parkinson's Disease

NCT07340073NOT YET RECRUITINGPHASE1

View Study

24 participants

INTERVENTIONAL

Started: May 1, 2026

Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease

NCT05557864RECRUITINGNA

View Study

24 participants

INTERVENTIONAL

Minneapolis, United States

Started: Aug 25, 2016

Sleep-specific DBS Therapy in Parkinson's Disease

NCT05962489RECRUITINGNA

View Study

64 participants

INTERVENTIONAL

Minneapolis, United States

Started: Jun 22, 2023

Completed Clinical Trials

11 completed trials for Deep Brain Stimulation (DBS) in Parkinson's disease

Deep Brain Stimulation for Parkinson's Disease Trial

NCT00053625COMPLETEDPHASE3

View Study

123 participants

INTERVENTIONAL

Atlanta, United States +1 more

Started: Jun 1, 1999

Effects of Deep Brain Stimulation (DBS) Frequency on Neural Synchrony

NCT02304848COMPLETEDNA

View Study

9 participants

INTERVENTIONAL

Stanford, United States

Started: Oct 1, 2012

Long-term Effect of Low Frequency Stimulation on Aspiration and Freezing of Gait in PD With STN DBS

NCT02549859COMPLETEDNA

View Study

11 participants

INTERVENTIONAL

Chicago, United States

Started: Aug 1, 2015