Neostigmine (for Acute Colonic Pseudo-obstruction)

Treatment for Paralytic ileus and intestinal obstruction

Typical Dosage: 2 mg IV over 3-5 minutes

Effectiveness
85%
Safety Score
50%
Clinical Trials
15
Participants
800

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
50
DangerousModerateSafe
Treatment Details
Dosage Range
2 mg IV over 3-5 minutes
Time to Effect
15-30 minutes for initial effect
Treatment Duration
Single dose, repeat if needed
Evidence Quality
MODERATE
Number Needed to Treat (NNT)
2(Treat 2 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
8(Treat 8 patients to see 1 additional serious adverse event)
Confidence Score
75%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$30
Monitoring:$750
Side Effect Mgmt:$50
Total Annual:$830
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
QALYs Gained
0.2
Outcome-Based Costs
Cost per Responder
$976
Cost per Remission
$1,038
Comparison vs Colonoscopic decompression
Cost Difference
$-5,000/year
Less expensive
QALY Difference
+0.05 QALYs
Better outcomes
Dominance
DOMINATESBetter + cheaper
Neostigmine (for Acute Colonic Pseudo-obstruction) Outcomes

for Paralytic ileus and intestinal obstruction

Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+85%
Remission Rate
+80%
Common Side Effects
Bradycardia
+15%
Abdominal Cramps
+20%
Nausea/Vomiting
+10%
Salivation
+8%

Sources:

nih.gov
qxmd.com
nih.gov

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov