Condition

Pancreatitis

Clinical trials and treatment information for Pancreatitis

5.9M
People Affected
150
Active Trials
472K
New Cases/Year
122K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Endoscopic Retrograde Cholangiopancreatography (ERCP) with Sphincterotomy and Stone Removal
90% Effectiveness• 90% Confidence• 55% Safety• 7 trials• 30K participants
HIGH EvidenceExcellent Value
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Comparative Safety Scale(Higher is safer)

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55
DangerousModerateSafe

Time to Effect

immediate

Duration

one-time procedure

Response Rate

90%

Remission Rate

%

Number Needed to Treat (NNT)

4

Number Needed to Harm (NNH)

15

Common Side Effects:

Post-ERCP pancreatitis: 8%
Bleeding: 1.5%
Perforation: 0.5%

Annual Cost of Care

Drug Cost

$500

Monitoring

$1,000

Side Effects

$5,000

Total Annual

$6,500

Cost-Effectiveness

EXCELLENT

QALYs Gained

1

ICER

$30,000/QALY

Cost per Responder

$7,222.22

Treatment Outcomes
Primary Outcomes
Serum Amylase500 U/L
-80% (-400 U/L)
Serum Lipase800 U/L
-85% (-680 U/L)
Total Bilirubin (in cases with obstructive jaundice)5.0 mg/dL
-70% (-3.5 mg/dL)
Abdominal Pain SeverityNumeric Rating Scale (NRS) pain: 8/10
-62.5% (-5 points)
Secondary Benefits
Recurrence Rate of Acute Pancreatitis (within 1 year)50% (of patients with recurrent biliary pancreatitis)
-80% (-40 percentage points)
Hospital Length of Stay7 days
-28.6% (-2 days)
C-reactive protein (CRP)150 mg/L
-70% (-105 mg/L)
Common Side Effects
Post-ERCP pancreatitis
+8%
Bleeding
+1.5%
Perforation
+0.5%

Clinical Trial Phases:

Phase 4
2
Pancreatic Enzyme Replacement Therapy (PERT)
85% Effectiveness• 90% Confidence• 85% Safety• 4 trials• 25K participants
HIGH EvidenceGood ValueDose: 25,000-80,000 lipase units per meal/snack
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Comparative Safety Scale(Higher is safer)

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Meth💀
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85
DangerousModerateSafe

Time to Effect

1-2 weeks

Duration

lifetime

Response Rate

85%

Remission Rate

%

Number Needed to Treat (NNT)

4

Common Side Effects:

Abdominal pain: 15%
Flatulence: 10%
Diarrhea: 7%

Annual Cost of Care

Drug Cost

$10,000

Monitoring

$300

Side Effects

$100

Total Annual

$10,400

Cost-Effectiveness

GOOD

QALYs Gained

0.2

ICER

$70,000/QALY

Cost per Responder

$12,235.29

Treatment Outcomes
Primary Outcomes
Fecal Fat Excretion (24-hour)25 g/24h
-70% (-17.5 g/24h)
Body Weight60 kg
+5% (+3 kg)
Abdominal Pain Score (0-10 NRS)7/10
-43% (-3 points)
Stool Frequency (episodes of steatorrhea per week)14 episodes/week
-71% (-10 episodes/week)
Secondary Benefits
Serum 25-hydroxyvitamin D20 ng/mL
+50% (+10 ng/mL)
Quality of Life (EQ-5D-5L index value)0.65
+23% (+0.15 points)
Serum Albumin3.2 g/dL
+19% (+0.6 g/dL)
Common Side Effects
Abdominal pain
+15%
Flatulence
+10%
Diarrhea
+7%

Clinical Trial Phases:

Phase 4
3
Intravenous Fluid Resuscitation (e.g., Lactated Ringer's)
85% Effectiveness• 90% Confidence• 85% Safety• 500 trials• 50K participants
HIGH EvidenceExcellent ValueDose: 5-10 mL/kg/hour initially, then titrated
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
85
DangerousModerateSafe

Time to Effect

immediate

Duration

days to weeks

Response Rate

85%

Remission Rate

%

Common Side Effects:

Fluid overload: 7%
Electrolyte imbalance: 7%
Pulmonary edema: 2%

Annual Cost of Care

Drug Cost

$50

Monitoring

$1,000

Side Effects

$100

Total Annual

$1,150

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.7

Cost per Responder

$1,352.94

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+85%
Common Side Effects
Fluid overload
+7%
Electrolyte imbalance
+7%
Pulmonary edema
+2%
4
Early Enteral Nutrition (via nasogastric or nasojejunal tube)
80% Effectiveness• 85% Confidence• 85% Safety• 250 trials• 20K participants
HIGH EvidenceExcellent ValueDose: gradually advanced, 25-50 mL/hour initial
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Comparative Safety Scale(Higher is safer)

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Meth💀
Cigarettes🚬
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Morphine💊
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Exercise🏃
Water💧
85
DangerousModerateSafe

Time to Effect

days

Duration

days to weeks

Response Rate

75%

Remission Rate

%

Number Needed to Treat (NNT)

7

Common Side Effects:

Diarrhea: 15%
Abdominal distension: 7%
Tube displacement: 7%

Annual Cost of Care

Drug Cost

$500

Monitoring

$1,000

Side Effects

$100

Total Annual

$1,600

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.8

Cost per Responder

$2,133.33

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+75%
Common Side Effects
Diarrhea
+15%
Abdominal distension
+7%
Tube displacement
+7%
5
Opioid Analgesics (e.g., Hydromorphone)
75% Effectiveness• 90% Confidence• 45% Safety• 400 trials• 40K participants
HIGH EvidenceModerate ValueDose: 0.5-2 mg IV every 2-4 hours; 2-8 mg oral every 3-6 hours
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
45
DangerousModerateSafe

Time to Effect

immediate (IV), 30-60 minutes (oral)

Duration

days to weeks (acute), long-term (chronic with caveats)

Response Rate

75%

Remission Rate

%

Number Needed to Treat (NNT)

2.5

Number Needed to Harm (NNH)

7

Common Side Effects:

Nausea: 25%
Constipation: 30%
Sedation: 20%
Respiratory depression: 3%
Addiction/Dependence (chronic use): 10%

Annual Cost of Care

Drug Cost

$50

Monitoring

$200

Side Effects

$1,000

Total Annual

$1,250

Cost-Effectiveness

MODERATE

QALYs Gained

0.1

Cost per Responder

$1,666.67

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+75%
Common Side Effects
Nausea
+25%
Constipation
+30%
Sedation
+20%

Clinical Trial Phases:

Phase 4