Duloxetine (SNRI)
Treatment for Osteoarthritis
Typical Dosage: 30-60mg daily
Effectiveness
68%
Safety Score
60%
Clinical Trials
3
Participants
10K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
30-60mg daily
Time to Effect
2-4 weeks
Treatment Duration
Ongoing
Evidence Quality
MODERATENumber Needed to Treat (NNT)
8(Treat 8 patients to see 1 additional successful outcome)
Confidence Score
75%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$900
Monitoring:$1,200
Side Effect Mgmt:$100
Total Annual:$2,200
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$40,000/QALY
QALYs Gained
0.07
Outcome-Based Costs
Cost per Responder
$1,818
Comparison vs Oral NSAIDs
Cost Difference
+$625/year
More expensive
QALY Difference
-0.01 QALYs
Worse outcomes
Dominance
No dominance
Duloxetine (SNRI) Outcomes
for Osteoarthritis
Efficacy Outcomes
Overall Effectiveness
+68%
Response Rate
+55%
Common Side Effects
Nausea
+15%
Dry mouth
+12%
Constipation
+12%
Fatigue/insomnia
+7%
Dizziness
+7%
Increased blood pressure
+3%
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
3 completed trials for Duloxetine (SNRI) in Osteoarthritis
Duloxetine As an Analgesic in Patients Without Central Sensitivity After Same Sitting Bilateral Total Knee Arthroplasty
NCT06837012COMPLETEDPHASE4
106 participants
INTERVENTIONAL
Mumbai, India
Started: Jan 1, 2021
Exercise Plus Duloxetine for Knee Osteoarthritis
NCT04111627COMPLETEDPHASE2
43 participants
INTERVENTIONAL
Baltimore, United States
Started: Oct 7, 2021
A Mechanism Based Proof of Concept Study of the Effects of Duloxetine in the Treatment of Patients With Osteoarthritic Knee Pain
NCT04224584COMPLETEDPHASE2
40 participants
INTERVENTIONAL
Aalborg, Denmark
Started: Jan 1, 2020