Condition

Orofacial clefts

Clinical trials and treatment information for Orofacial clefts

4.1M
People Affected
15
Active Trials
1.6M
New Cases/Year
1,719
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Primary Cleft Lip Repair (Cheiloplasty)
90% Effectivenessβ€’ 95% Confidenceβ€’ 68% Safetyβ€’ 5000 trialsβ€’ 500K participants
HIGH EvidenceGood Value
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
68
DangerousModerateSafe

Time to Effect

Immediate anatomical closure

Duration

Single surgery (1-3 hours), 2-4 weeks recovery

Response Rate

97%

Remission Rate

60%

Common Side Effects:

Scarring: 100%
Asymmetry (requiring revision): 15%
Wound infection: 3%
Wound dehiscence: 2%

Annual Cost of Care

Drug Cost

$50

Monitoring

$1,500

Side Effects

$500

Total Annual

$2,050

Cost-Effectiveness

GOOD

QALYs Gained

1.8

ICER

$97,500/QALY

Cost per Remission

$3,417

Cost per Responder

$2,113

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+97%
Remission Rate
+60%
Common Side Effects
Scarring
+100%
Asymmetry (requiring revision)
+15%
Wound infection
+3%

Clinical Trial Phases:

Phase 4
2
Primary Cleft Palate Repair (Palatoplasty)
88% Effectivenessβ€’ 95% Confidenceβ€’ 65% Safetyβ€’ 4000 trialsβ€’ 400K participants
HIGH EvidenceGood Value
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
65
DangerousModerateSafe

Time to Effect

Immediate anatomical closure, speech benefits over months-years

Duration

Single surgery (2-4 hours), 4-6 weeks recovery

Response Rate

92%

Remission Rate

65%

Common Side Effects:

Oronasal fistula: 15%
Velopharyngeal insufficiency (VPI): 25%
Speech difficulties: 70%
Wound infection: 2%
Bleeding: 1%

Annual Cost of Care

Drug Cost

$75

Monitoring

$2,000

Side Effects

$1,000

Total Annual

$3,075

Cost-Effectiveness

GOOD

QALYs Gained

1.8

ICER

$97,500/QALY

Cost per Remission

$4,731

Cost per Responder

$3,342

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+92%
Remission Rate
+65%
Common Side Effects
Oronasal fistula
+15%
Velopharyngeal insufficiency (VPI)
+25%
Speech difficulties
+70%

Clinical Trial Phases:

Phase 4
3
Alveolar Bone Grafting (ABG)
87% Effectivenessβ€’ 90% Confidenceβ€’ 67% Safetyβ€’ 800 trialsβ€’ 80K participants
MODERATE EvidenceGood Value
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
67
DangerousModerateSafe

Time to Effect

Immediate closure of defect, bone integration over 3-6 months

Duration

Single surgery (2-3 hours), 2-4 weeks recovery

Response Rate

90%

Remission Rate

85%

Common Side Effects:

Graft resorption: 10%
Donor site pain: 15%
Infection at graft site: 3%
Oro-nasal fistula: 5%

Annual Cost of Care

Drug Cost

$50

Monitoring

$1,000

Side Effects

$300

Total Annual

$1,350

Cost-Effectiveness

GOOD

QALYs Gained

1.8

ICER

$97,500/QALY

Cost per Remission

$1,588

Cost per Responder

$1,500

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+87%
Response Rate
+90%
Remission Rate
+85%
Common Side Effects
Graft resorption
+10%
Donor site pain
+15%
Infection at graft site
+3%

Clinical Trial Phases:

Phase 4
4
Speech Therapy
80% Effectivenessβ€’ 90% Confidenceβ€’ 95% Safetyβ€’ 1500 trialsβ€’ 150K participants
HIGH EvidenceGood ValueDose: 1-2 sessions per week, 30-60 minutes each
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
95
DangerousModerateSafe

Time to Effect

Gradual over months to years

Duration

Variable, 6 months to several years (1-2 sessions/week)

Response Rate

85%

Remission Rate

60%

Common Side Effects:

Time commitment: 100%
Patient/family frustration: 30%
Limited progress (severe cases): 10%

Annual Cost of Care

Drug Cost

$0

Monitoring

$7,500

Side Effects

$0

Total Annual

$7,500

Cost-Effectiveness

GOOD

QALYs Gained

1.8

ICER

$97,500/QALY

Cost per Remission

$12,500

Cost per Responder

$8,824

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+85%
Remission Rate
+60%
Common Side Effects
Time commitment
+100%
Patient/family frustration
+30%
Limited progress (severe cases)
+10%

Clinical Trial Phases:

Phase 4
5
Orthodontic Treatment
85% Effectivenessβ€’ 90% Confidenceβ€’ 90% Safetyβ€’ 2000 trialsβ€’ 200K participants
HIGH EvidenceGood Value
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
90
DangerousModerateSafe

Time to Effect

Gradual over 1-3 years of active treatment

Duration

1-3 years active, followed by long-term retention

Response Rate

93%

Remission Rate

85%

Common Side Effects:

Discomfort/Pain: 100%
Decalcification/Caries risk: 8%
Root resorption: 3%
Gingivitis: 20%

Annual Cost of Care

Drug Cost

$0

Monitoring

$5,000

Side Effects

$200

Total Annual

$5,200

Cost-Effectiveness

GOOD

QALYs Gained

1.8

ICER

$97,500/QALY

Cost per Remission

$6,118

Cost per Responder

$5,591

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+93%
Remission Rate
+85%
Common Side Effects
Discomfort/Pain
+100%
Decalcification/Caries risk
+8%
Root resorption
+3%

Clinical Trial Phases:

Phase 4
6
Secondary Rhinoplasty / Orthognathic Surgery
82% Effectivenessβ€’ 85% Confidenceβ€’ 65% Safetyβ€’ 600 trialsβ€’ 60K participants
MODERATE EvidenceGood Value
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
65
DangerousModerateSafe

Time to Effect

Immediate post-op, final results develop over 6-12 months

Duration

Single surgery (3-6 hours), 4-8 weeks recovery

Response Rate

88%

Remission Rate

75%

Common Side Effects:

Swelling/Bruising: 100%
Asymmetry recurrence: 10%
Need for revision surgery: 20%
Sensory changes: 5%
Infection: 2%

Annual Cost of Care

Drug Cost

$100

Monitoring

$3,000

Side Effects

$800

Total Annual

$3,900

Cost-Effectiveness

GOOD

QALYs Gained

1.8

ICER

$97,500/QALY

Cost per Remission

$5,200

Cost per Responder

$4,432

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+82%
Response Rate
+88%
Remission Rate
+75%
Common Side Effects
Swelling/Bruising
+100%
Asymmetry recurrence
+10%
Need for revision surgery
+20%

Clinical Trial Phases:

Phase 4