Condition

Non-rheumatic degenerative mitral valve disease

Clinical trials and treatment information for Non-rheumatic degenerative mitral valve disease

15.5M
People Affected
50
Active Trials
310K
New Cases/Year
37K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Mitral Valve Repair (Surgical)
90% Effectiveness• 95% Confidence• 55% Safety• 1500 trials• 500K participants
HIGH EvidenceExcellent Value
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
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55
DangerousModerateSafe

Time to Effect

Immediate symptom relief post-recovery (full recovery 3-6 months)

Duration

One-time procedure

Response Rate

95%

Remission Rate

90%

Common Side Effects:

Arrhythmias (e.g., Atrial Fibrillation): 30%
Bleeding/Transfusion: 10%
Stroke: 2%
Infection: 3%
Acute Kidney Injury: 7%
In-hospital Mortality: 2%

Annual Cost of Care

Drug Cost

$0

Monitoring

$1,500

Side Effects

$500

Total Annual

$2,000

Cost-Effectiveness

EXCELLENT

QALYs Gained

4.5

ICER

$35,000/QALY

Cost per Remission

$2,222.22

Cost per Responder

$2,105.26

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+95%
Remission Rate
+90%
Common Side Effects
Arrhythmias (e.g., Atrial Fibrillation)
+30%
Bleeding/Transfusion
+10%
Stroke
+2%

Clinical Trial Phases:

Phase 4
2
Mitral Valve Replacement (Surgical)
88% Effectiveness• 95% Confidence• 50% Safety• 1200 trials• 400K participants
HIGH EvidenceExcellent Value
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
50
DangerousModerateSafe

Time to Effect

Immediate symptom relief post-recovery (full recovery 3-6 months)

Duration

One-time procedure (lifelong anticoagulation for mechanical valve)

Response Rate

95%

Remission Rate

90%

Common Side Effects:

Arrhythmias (e.g., Atrial Fibrillation): 28%
Bleeding/Transfusion: 10%
Stroke: 2.5%
Infection: 3%
Acute Kidney Injury: 7%
In-hospital Mortality: 3.5%
Anticoagulation-related bleeding (with mechanical valve): 2.5%
Bioprosthetic valve degeneration/re-operation: 15%

Annual Cost of Care

Drug Cost

$1,000

Monitoring

$1,500

Side Effects

$750

Total Annual

$3,250

Cost-Effectiveness

EXCELLENT

QALYs Gained

4

ICER

$45,000/QALY

Cost per Remission

$3,611.11

Cost per Responder

$3,421.05

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+95%
Remission Rate
+90%
Common Side Effects
Arrhythmias (e.g., Atrial Fibrillation)
+28%
Bleeding/Transfusion
+10%
Stroke
+2.5%

Clinical Trial Phases:

Phase 4
3
Transcatheter Edge-to-Edge Repair (TEER)
75% Effectiveness• 90% Confidence• 60% Safety• 100 trials• 20K participants
HIGH EvidenceGood Value
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe

Time to Effect

1-3 months for symptom improvement

Duration

One-time procedure

Response Rate

80%

Remission Rate

55%

Common Side Effects:

Vascular complications (access site): 7%
New-onset Atrial Fibrillation: 7%
MR recurrence/residual MR: 15%
Single-leaflet device thrombosis: 0.5%
In-hospital Mortality: 3.5%

Annual Cost of Care

Drug Cost

$0

Monitoring

$2,000

Side Effects

$750

Total Annual

$2,750

Cost-Effectiveness

GOOD

QALYs Gained

3

ICER

$90,000/QALY

Cost per Remission

$5,000

Cost per Responder

$3,437.5

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+80%
Remission Rate
+55%
Common Side Effects
Vascular complications (access site)
+7%
New-onset Atrial Fibrillation
+7%
MR recurrence/residual MR
+15%

Clinical Trial Phases:

Phase 3Phase 4
4
Diuretics (e.g., Furosemide) for Symptom Management
60% Effectiveness• 95% Confidence• 70% Safety• 800 trials• 150K participants
HIGH EvidenceExcellent ValueDose: Furosemide 20-80mg daily/BID
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

Hours

Duration

Lifetime

Response Rate

85%

Remission Rate

0%

Common Side Effects:

Electrolyte imbalance (e.g., hypokalemia): 20%
Dehydration/Hypotension: 10%
Renal dysfunction: 7%
Ototoxicity (with high doses): 0.5%

Annual Cost of Care

Drug Cost

$100

Monitoring

$500

Side Effects

$100

Total Annual

$700

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.2

ICER

$10,000/QALY

Cost per Responder

$823.53

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+85%
Common Side Effects
Electrolyte imbalance (e.g., hypokalemia)
+20%
Dehydration/Hypotension
+10%
Renal dysfunction
+7%

Clinical Trial Phases:

Phase 4
5
Medical Management / Watchful Waiting
40% Effectiveness• 85% Confidence• 80% Safety• 500 trials• 200K participants
HIGH EvidenceDose: Varies by medication (e.g., Lisinopril 5-40mg daily, Metoprolol 25-200mg daily)
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
80
DangerousModerateSafe

Time to Effect

Days to weeks for symptom management

Duration

Lifetime

Response Rate

65%

Remission Rate

0%

Common Side Effects:

Fatigue (from beta-blockers): 15%
Cough (from ACE inhibitors): 10%
Dizziness/Hypotension: 7%

Annual Cost of Care

Drug Cost

$1,000

Monitoring

$1,500

Side Effects

$200

Total Annual

$2,700

0

Cost per Responder

$4,153.85

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+40%
Response Rate
+65%
Common Side Effects
Fatigue (from beta-blockers)
+15%
Cough (from ACE inhibitors)
+10%
Dizziness/Hypotension
+7%

Clinical Trial Phases:

Phase 4