Condition

Non-rheumatic calcific aortic valve disease

Clinical trials and treatment information for Non-rheumatic calcific aortic valve disease

13.3M
People Affected
150
Active Trials
266K
New Cases/Year
142K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Surgical Aortic Valve Replacement (SAVR)
92% Effectiveness• 98% Confidence• 40% Safety• 800 trials• 200K participants
HIGH EvidenceGood Value
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
40
DangerousModerateSafe

Time to Effect

Immediate hemodynamic improvement, symptomatic relief within weeks to months post-recovery

Duration

One-time procedure; valve durability 10-20+ years; initial procedure cost $25,000-$50,000.

Response Rate

92%

Remission Rate

99%

Number Needed to Treat (NNT)

2

Common Side Effects:

Major bleeding: 15%
Stroke: 2%
Acute kidney injury: 10%
Atrial fibrillation: 20%
Sternal wound infection: 3%
Prolonged recovery: 30%

Annual Cost of Care

Drug Cost

$0

Monitoring

$1,500

Side Effects

$1,200

Total Annual

$2,700

Cost-Effectiveness

GOOD

QALYs Gained

1.6

ICER

$70,000/QALY

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+92%
Response Rate
+92%
Remission Rate
+99%
Common Side Effects
Major bleeding
+15%
Stroke
+2%
Acute kidney injury
+10%

Clinical Trial Phases:

Phase 4
2
Transcatheter Aortic Valve Replacement (TAVR)
90% Effectiveness• 95% Confidence• 45% Safety• 550 trials• 120K participants
HIGH EvidenceGood Value
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
45
DangerousModerateSafe

Time to Effect

Immediate hemodynamic improvement, symptomatic relief within days to weeks

Duration

One-time procedure; valve durability 10-15+ years; initial procedure cost $30,000-$60,000.

Response Rate

90%

Remission Rate

98%

Number Needed to Treat (NNT)

3

Common Side Effects:

Vascular complications: 7%
Stroke: 3%
New pacemaker implantation: 15%
Paravalvular leak (moderate/severe): 4%
Acute kidney injury: 8%

Annual Cost of Care

Drug Cost

$0

Monitoring

$1,500

Side Effects

$1,000

Total Annual

$2,500

Cost-Effectiveness

GOOD

QALYs Gained

1.5

ICER

$80,000/QALY

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+90%
Remission Rate
+98%
Common Side Effects
Vascular complications
+7%
Stroke
+3%
New pacemaker implantation
+15%

Clinical Trial Phases:

Phase 4
3
Diuretic Therapy (e.g., Furosemide)
30% Effectiveness• 80% Confidence• 65% Safety• 200 trials• 50K participants
MODERATE EvidenceExcellent ValueDose: 20-80mg daily (Furosemide)
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe

Time to Effect

Hours (for symptom relief)

Duration

Lifetime (as needed for symptoms)

Response Rate

70%

Remission Rate

0%

Common Side Effects:

Hypotension: 15%
Electrolyte imbalance (hypokalemia): 20%
Renal dysfunction: 5%
Dizziness/lightheadedness: 10%

Annual Cost of Care

Drug Cost

$100

Monitoring

$200

Side Effects

$100

Total Annual

$400

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.05

Cost per Responder

$571

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+30%
Response Rate
+70%
Common Side Effects
Hypotension
+15%
Electrolyte imbalance (hypokalemia)
+20%
Renal dysfunction
+5%

Clinical Trial Phases:

Phase 4
4
Watchful Waiting / Cardiovascular Risk Factor Modification
10% Effectiveness• 90% Confidence• 95% Safety• 100 trials• 40K participants
HIGH EvidenceExcellent Value
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
95
DangerousModerateSafe

Time to Effect

Long-term (for risk factor benefits), immediate (for watchful waiting assessment)

Duration

Lifetime (for monitoring and lifestyle)

Response Rate

%

Remission Rate

0%

Common Side Effects:

No direct side effects, but progression of AS may occur: 100%

Annual Cost of Care

Drug Cost

$0

Monitoring

$500

Side Effects

$0

Total Annual

$500

Cost-Effectiveness

EXCELLENT
0
Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+10%
Common Side Effects
No direct side effects, but progression of AS may occur
+100%

Clinical Trial Phases:

Phase 4
5
Statins (e.g., Atorvastatin)
5% Effectiveness• 90% Confidence• 65% Safety• 150 trials• 60K participants
HIGH EvidenceExcellent ValueDose: 10-80mg daily (Atorvastatin)
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe

Time to Effect

Not applicable (no effect on AS progression)

Duration

Lifetime (for lipid management)

Response Rate

0%

Remission Rate

0%

Common Side Effects:

Myalgia: 10%
Liver enzyme elevation: 3%
Gastrointestinal upset: 5%

Annual Cost of Care

Drug Cost

$50

Monitoring

$100

Side Effects

$50

Total Annual

$200

Cost-Effectiveness

EXCELLENT
0
Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+5%
Common Side Effects
Myalgia
+10%
Liver enzyme elevation
+3%
Gastrointestinal upset
+5%

Clinical Trial Phases:

Phase 4