Condition

Maternal hypertensive disorders

Clinical trials and treatment information for Maternal hypertensive disorders

3.5M
People Affected
50
Active Trials
20M
New Cases/Year
38K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Labetalol
88% Effectiveness• 92% Confidence• 72% Safety• 200 trials• 5K participants
HIGH EvidenceExcellent ValueDose: 100-400 mg 2-3 times daily
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Comparative Safety Scale(Higher is safer)

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72
DangerousModerateSafe

Time to Effect

30-90 minutes (oral)

Duration

Until delivery

Response Rate

85%

Remission Rate

%

Number Needed to Treat (NNT)

5

Common Side Effects:

Dizziness: 15%
Nausea: 7%
Fatigue: 6%
Scalp tingling: 3%
Fetal bradycardia: 0.5%

Annual Cost of Care

Drug Cost

$150

Monitoring

$1,000

Side Effects

$200

Total Annual

$1,350

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.3

Cost per Responder

$1,588

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+85%
Common Side Effects
Dizziness
+15%
Nausea
+7%
Fatigue
+6%

Clinical Trial Phases:

Phase 4
2
Nifedipine (extended-release)
87% Effectiveness• 91% Confidence• 71% Safety• 150 trials• 4K participants
HIGH EvidenceExcellent ValueDose: 30-90 mg once daily
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Comparative Safety Scale(Higher is safer)

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71
DangerousModerateSafe

Time to Effect

30-60 minutes (oral)

Duration

Until delivery

Response Rate

85%

Remission Rate

%

Number Needed to Treat (NNT)

6

Common Side Effects:

Headache: 20%
Flushing: 15%
Dizziness: 10%
Peripheral edema: 7%

Annual Cost of Care

Drug Cost

$150

Monitoring

$1,000

Side Effects

$200

Total Annual

$1,350

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.3

Cost per Responder

$1,588

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+87%
Response Rate
+85%
Common Side Effects
Headache
+20%
Flushing
+15%
Dizziness
+10%

Clinical Trial Phases:

Phase 4
3
Magnesium Sulfate
95% Effectiveness• 95% Confidence• 58% Safety• 1 trials• 20K participants
HIGH EvidenceExcellent ValueDose: 4-6 g IV loading dose, then 1-2 g/hour infusion
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Comparative Safety Scale(Higher is safer)

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58
DangerousModerateSafe

Time to Effect

immediate (IV)

Duration

24 hours post-delivery or post-seizure

Response Rate

90%

Remission Rate

%

Number Needed to Treat (NNT)

18

Common Side Effects:

Flushing: 15%
Warmth: 15%
Nausea: 7%
Headache: 7%
Muscle weakness: 5%
Respiratory depression: 0.5%

Annual Cost of Care

Drug Cost

$0

Monitoring

$1,200

Side Effects

$0

Total Annual

$1,200

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.8

Treatment Outcomes
Primary Outcomes
Incidence of Eclamptic SeizuresEstimated risk in severe preeclampsia without MgSO4: 2.5%
-58% (-1.45% absolute risk reduction)
Incidence of Severe Maternal Morbidity (e.g., pulmonary edema, renal failure)Estimated risk in severe preeclampsia: 5%
-35% (-1.75% absolute risk reduction)
Systolic Blood Pressure160 mmHg
-9.4% (-15 mmHg)
Diastolic Blood Pressure110 mmHg
-10.9% (-12 mmHg)
Secondary Benefits
Incidence of Cerebral Palsy in preterm offspring (<34 weeks gestation)Estimated risk in preterm births <34 weeks: 10%
-32% (-3.2% absolute risk reduction)
Incidence of Hypertensive Crisis Requiring Acute InterventionEstimated risk in severe preeclampsia: 15%
-25% (-3.75% absolute risk reduction)
Headache Severity (NRS 0-10 scale)6/10
-33.3% (-2 points)
Common Side Effects
Flushing
+15%
Warmth
+15%
Nausea
+7%

Clinical Trial Phases:

Phase 4
4
Hydralazine (IV)
85% Effectiveness• 90% Confidence• 68% Safety• 50 trials• 2K participants
HIGH EvidenceExcellent ValueDose: 5 mg IV bolus, then 5-10 mg every 20-30 min
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Comparative Safety Scale(Higher is safer)

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Meth💀
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68
DangerousModerateSafe

Time to Effect

10-20 minutes (IV)

Duration

Short-term, acute management

Response Rate

80%

Remission Rate

%

Common Side Effects:

Headache: 15%
Flushing: 10%
Tachycardia: 7%
Nausea: 7%
Hypotension: 5%

Annual Cost of Care

Drug Cost

$0

Monitoring

$1,200

Side Effects

$0

Total Annual

$1,200

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.2

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+80%
Common Side Effects
Headache
+15%
Flushing
+10%
Tachycardia
+7%

Clinical Trial Phases:

Phase 4
5
Methyldopa
82% Effectiveness• 90% Confidence• 69% Safety• 100 trials• 3K participants
HIGH EvidenceExcellent ValueDose: 250-500 mg 2-4 times daily
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Comparative Safety Scale(Higher is safer)

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69
DangerousModerateSafe

Time to Effect

2-6 hours (oral)

Duration

Until delivery

Response Rate

80%

Remission Rate

%

Number Needed to Treat (NNT)

8

Common Side Effects:

Drowsiness: 25%
Dry mouth: 12%
Headache: 8%
Dizziness: 8%

Annual Cost of Care

Drug Cost

$50

Monitoring

$1,000

Side Effects

$250

Total Annual

$1,300

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.25

Cost per Responder

$1,625

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+82%
Response Rate
+80%
Common Side Effects
Drowsiness
+25%
Dry mouth
+12%
Headache
+8%

Clinical Trial Phases:

Phase 4
6
Low-dose Aspirin
80% Effectiveness• 95% Confidence• 81% Safety• 100 trials• 30K participants
HIGH EvidenceExcellent ValueDose: 81-150 mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
81
DangerousModerateSafe

Time to Effect

Weeks-months (preventive effect)

Duration

12-16 weeks gestation until delivery

Response Rate

15%

Remission Rate

%

Number Needed to Treat (NNT)

30

Number Needed to Harm (NNH)

1000

Common Side Effects:

Minor bleeding (nosebleeds, bruising): 7%
Gastrointestinal upset: 3%
Major bleeding: 0.1%

Annual Cost of Care

Drug Cost

$20

Monitoring

$25

Side Effects

$25

Total Annual

$70

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.005

ICER

$5,000/QALY

Cost per Responder

$467

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+15%
Common Side Effects
Minor bleeding (nosebleeds, bruising)
+7%
Gastrointestinal upset
+3%
Major bleeding
+0.1%

Clinical Trial Phases:

Phase 4