Quinine Sulfate + Doxycycline

Treatment for Malaria

Typical Dosage: Quinine: 600mg salt 3 times daily for 7 days. Doxycycline: 100mg daily for 7 days

Effectiveness
90%
Safety Score
60%
Clinical Trials
1
Participants
30K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
Quinine: 600mg salt 3 times daily for 7 days. Doxycycline: 100mg daily for 7 days
Time to Effect
2-4 days
Treatment Duration
7 days (quinine) + 7 days (doxycycline)
Evidence Quality
HIGH
Confidence Score
80%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$35
Monitoring:$100
Side Effect Mgmt:$30
Total Annual:$165
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOOD
QALYs Gained
0.07
Outcome-Based Costs
Cost per Responder
$183.3
Cost per Remission
$183.3
Comparison vs Artemether-Lumefantrine (if ACT fails)
Cost Difference
+$95/year
More expensive
QALY Difference
+0.02 QALYs
Better outcomes
Dominance
No dominance
Quinine Sulfate + Doxycycline Outcomes

for Malaria

Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+90%
Remission Rate
+90%
Common Side Effects
Cinchonism (tinnitus, headache, nausea, visual disturbances)
+50%
Hypoglycemia
+10%
QTc prolongation
+30%
Photosensitivity (doxycycline)
+10%

Sources:

hiv.gov
who.int
cdc.gov

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov

Completed Clinical Trials
1 completed trial for Quinine Sulfate + Doxycycline in Malaria

Artemisinin Resistance in Bangladesh

NCT00639873COMPLETEDNA
View Study
126 participants
INTERVENTIONAL
Bandarban Sadar, Bangladesh
Started: Jun 1, 2008