Cilostazol

Treatment for Lower extremity peripheral arterial disease

Typical Dosage: 100mg twice daily

Effectiveness
65%
Safety Score
70%
Clinical Trials
4
Participants
12K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
70
DangerousModerateSafe
Treatment Details
Dosage Range
100mg twice daily
Time to Effect
2-4 weeks
Treatment Duration
Long-term, as needed
Evidence Quality
HIGH
Number Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
15(Treat 15 patients to see 1 additional serious adverse event)
Confidence Score
88%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$500
Monitoring:$50
Side Effect Mgmt:$100
Total Annual:$650
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
MODERATE
ICER
$90,000/QALY
QALYs Gained
0.06
Outcome-Based Costs
Cost per Responder
$1,083
Cost per Remission
$1,625
Prescription Access Economics
Annual Societal Loss per Patient
$510
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$250/year
Time Cost
$120/year
Travel + wait time
Insurance Admin Cost
$240/year
Prior auth, claims
Rx Price
$500/year
Potential OTC Price
$200/year
Estimated if OTC available
Early Treatment Benefit
+0.05 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
LOW
Missed Diagnosis Risk
LOW
Cilostazol Outcomes

for Lower extremity peripheral arterial disease

Efficacy Outcomes
Overall Effectiveness
+65%
Response Rate
+60%
Remission Rate
+40%
Common Side Effects
Headache
+25%
Diarrhea
+15%
Palpitations/Tachycardia
+10%
Dizziness
+10%

Sources:

nih.gov
nih.gov
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov

Completed Clinical Trials
2 completed trials for Cilostazol in Lower extremity peripheral arterial disease

Comparative Effectiveness Research Study of Peripheral Arterial Disease (PAD)

NCT01378260COMPLETED
View Study
323 participants
OBSERVATIONAL
Bellevue, United States +11 more
Started: Jul 1, 2011

Study to Explore the Effect of Lowering Blood Viscosity in Patients With Treatment-resistant Critical Limb Ischemia

NCT01758874COMPLETEDPHASE2
View Study
20 participants
INTERVENTIONAL
Seoul, South Korea
Started: Sep 1, 2006