Metformin
Treatment for Long COVID
Typical Dosage: 500mg twice daily for 10-14 days (acute), or 500-1000mg daily for Long COVID
Effectiveness
45%
Safety Score
65%
Clinical Trials
2
Participants
3.5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe
Treatment Details
Dosage Range
500mg twice daily for 10-14 days (acute), or 500-1000mg daily for Long COVID
Time to Effect
Weeks to months
Treatment Duration
10-14 days (acute prevention), several months (for existing Long COVID)
Evidence Quality
MODERATENumber Needed to Treat (NNT)
18(Treat 18 patients to see 1 additional successful outcome)
Confidence Score
55%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$120
Monitoring:$100
Side Effect Mgmt:$50
Total Annual:$270
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
0.1
Outcome-Based Costs
Cost per Responder
$900
Metformin Outcomes
for Long COVID
Efficacy Outcomes
Overall Effectiveness
+45%
Response Rate
+30%
Common Side Effects
Diarrhea
+25%
Nausea/Vomiting
+12%
Abdominal discomfort
+8%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!
Active Clinical Trials
1 active trial recruiting for Metformin in Long COVID
RECLAIM Adaptive Platform Trial for PCC Treatments
NCT07280572ENROLLING BY INVITATIONPHASE3
1.25K participants
INTERVENTIONAL
Utrecht, Netherlands
Started: Feb 17, 2025
Completed Clinical Trials
1 completed trial for Metformin in Long COVID
A Multicenter, Adaptive, Randomized, doublE-blinded, Placebo-controlled Study in Participants With Long COVID-19: The REVIVE Trial
NCT06128967COMPLETEDPHASE3
399 participants
INTERVENTIONAL
Belo Horizonte, Brazil +5 more
Started: Oct 18, 2023