Condition

Liver cancer due to NASH

Clinical trials and treatment information for Liver cancer due to NASH

52K
People Affected
30
Active Trials
31K
New Cases/Year
41K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Liver Transplantation
95% Effectiveness• 92% Confidence• 25% Safety• 5000 trials• 200K participants
HIGH EvidenceModerate Value
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Comparative Safety Scale(Higher is safer)

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Meth💀
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25
DangerousModerateSafe

Time to Effect

immediate

Duration

lifetime

Response Rate

100%

Remission Rate

75%

Number Needed to Treat (NNT)

3

Number Needed to Harm (NNH)

8

Common Side Effects:

Surgical complications (bleeding, infection): 15%
Acute rejection: 18%
Chronic kidney disease (due to immunosuppressants): 20%
Infections (opportunistic): 40%
Recurrence of HCC: 15%

Annual Cost of Care

Drug Cost

$15,000

Monitoring

$10,000

Side Effects

$15,000

Total Annual

$40,000

Cost-Effectiveness

MODERATE

QALYs Gained

7

ICER

$100,000/QALY

Cost per Remission

$53,333

Cost per Responder

$40,000

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+95%
Response Rate
+100%
Remission Rate
+75%
Common Side Effects
Surgical complications (bleeding, infection)
+15%
Acute rejection
+18%
Chronic kidney disease (due to immunosuppressants)
+20%
2
Atezolizumab + Bevacizumab
88% Effectiveness• 90% Confidence• 35% Safety• 10 trials• 3K participants
HIGH EvidencePoor ValueDose: Atezolizumab 1200mg IV every 3 weeks + Bevacizumab 15mg/kg IV every 3 weeks
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Comparative Safety Scale(Higher is safer)

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Meth💀
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Chemo☢️
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35
DangerousModerateSafe

Time to Effect

1-2 months

Duration

until progression or unacceptable toxicity

Response Rate

27%

Remission Rate

6%

Number Needed to Treat (NNT)

8

Number Needed to Harm (NNH)

5

Common Side Effects:

Hypertension (grade 3-4): 23%
Fatigue: 42%
Diarrhea: 24%
Proteinuria (grade 3-4): 8%
Hemorrhage/Bleeding (grade 3-4): 15%
Immune-related hepatitis: 10%

Annual Cost of Care

Drug Cost

$300,000

Monitoring

$8,000

Side Effects

$15,000

Total Annual

$323,000

Cost-Effectiveness

POOR

QALYs Gained

0.4

ICER

$400,000/QALY

Cost per Remission

$5,383,333

Cost per Responder

$1,196,296

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+27%
Remission Rate
+6%
Common Side Effects
Hypertension (grade 3-4)
+23%
Fatigue
+42%
Diarrhea
+24%

Clinical Trial Phases:

Phase 3Phase 4
3
Lenvatinib
85% Effectiveness• 88% Confidence• 40% Safety• 5 trials• 2K participants
HIGH EvidencePoor ValueDose: 8mg or 12mg orally once daily
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Comparative Safety Scale(Higher is safer)

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Meth💀
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Chemo☢️
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40
DangerousModerateSafe

Time to Effect

1-2 months

Duration

until progression or unacceptable toxicity

Response Rate

24%

Remission Rate

2%

Number Needed to Treat (NNT)

6

Number Needed to Harm (NNH)

4

Common Side Effects:

Hypertension (grade 3-4): 24%
Fatigue: 44%
Diarrhea: 39%
Decreased appetite: 34%
Proteinuria: 26%
Palmar-plantar erythrodysesthesia: 26%

Annual Cost of Care

Drug Cost

$240,000

Monitoring

$8,000

Side Effects

$10,000

Total Annual

$258,000

Cost-Effectiveness

POOR

QALYs Gained

0.2

ICER

$350,000/QALY

Cost per Remission

$12,900,000

Cost per Responder

$1,075,000

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+24%
Remission Rate
+2%
Common Side Effects
Hypertension (grade 3-4)
+24%
Fatigue
+44%
Diarrhea
+39%

Clinical Trial Phases:

Phase 3Phase 4
4
Radiofrequency Ablation (RFA) / Microwave Ablation (MWA)
80% Effectiveness• 88% Confidence• 60% Safety• 300 trials• 20K participants
HIGH EvidenceExcellent Value
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe

Time to Effect

immediate

Duration

single session, may be repeated

Response Rate

90%

Remission Rate

%

Number Needed to Treat (NNT)

2

Number Needed to Harm (NNH)

30

Common Side Effects:

Pain: 35%
Fever: 20%
Liver abscess/infection: 3%
Bleeding/hemorrhage: 3%
Adjacent organ injury: 3%

Annual Cost of Care

Drug Cost

$500

Monitoring

$5,000

Side Effects

$2,000

Total Annual

$22,500

Cost-Effectiveness

EXCELLENT

QALYs Gained

3

ICER

$30,000/QALY

Cost per Responder

$25,000

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+90%
Common Side Effects
Pain
+35%
Fever
+20%
Liver abscess/infection
+3%
5
Stereotactic Body Radiation Therapy (SBRT)
75% Effectiveness• 80% Confidence• 50% Safety• 50 trials• 5K participants
MODERATE EvidenceGood ValueDose: 30-60 Gy in 3-5 fractions
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Comparative Safety Scale(Higher is safer)

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50
DangerousModerateSafe

Time to Effect

weeks to months

Duration

1-5 fractions, typically 1 week

Response Rate

80%

Remission Rate

%

Number Needed to Treat (NNT)

4

Number Needed to Harm (NNH)

15

Common Side Effects:

Fatigue: 30%
Nausea/vomiting: 15%
Pain: 10%
Radiation-induced liver disease (RILD): 7%

Annual Cost of Care

Drug Cost

$0

Monitoring

$6,000

Side Effects

$2,000

Total Annual

$38,000

Cost-Effectiveness

GOOD

QALYs Gained

1.5

ICER

$70,000/QALY

Cost per Responder

$47,500

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+80%
Common Side Effects
Fatigue
+30%
Nausea/vomiting
+15%
Pain
+10%

Clinical Trial Phases:

Phase 2Phase 3
6
Transarterial Chemoembolization (TACE)
75% Effectiveness• 85% Confidence• 55% Safety• 200 trials• 15K participants
HIGH EvidenceGood Value
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
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55
DangerousModerateSafe

Time to Effect

days to weeks

Duration

1-3 sessions, often repeated every 3-6 months

Response Rate

60%

Remission Rate

%

Number Needed to Treat (NNT)

5

Number Needed to Harm (NNH)

15

Common Side Effects:

Post-embolization syndrome (fever, pain, nausea): 80%
Liver dysfunction/failure (severe): 7%
Bile duct injury/abscess: 3%
Vascular injury: 3%

Annual Cost of Care

Drug Cost

$10,000

Monitoring

$8,000

Side Effects

$3,000

Total Annual

$61,000

Cost-Effectiveness

GOOD

QALYs Gained

1

ICER

$50,000/QALY

Cost per Responder

$101,667

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+60%
Common Side Effects
Post-embolization syndrome (fever, pain, nausea)
+80%
Liver dysfunction/failure (severe)
+7%
Bile duct injury/abscess
+3%
7
Sorafenib
70% Effectiveness• 85% Confidence• 45% Safety• 10 trials• 5K participants
HIGH EvidencePoor ValueDose: 400mg orally twice daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
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45
DangerousModerateSafe

Time to Effect

1-2 months

Duration

until disease progression or unacceptable toxicity

Response Rate

3%

Remission Rate

0.5%

Number Needed to Treat (NNT)

10

Number Needed to Harm (NNH)

5

Common Side Effects:

Diarrhea: 55%
Palmar-plantar erythrodysesthesia: 50%
Fatigue: 40%
Rash: 40%
Weight loss: 30%
Hypertension: 20%

Annual Cost of Care

Drug Cost

$50,000

Monitoring

$7,000

Side Effects

$8,000

Total Annual

$65,000

Cost-Effectiveness

POOR

QALYs Gained

0.1

ICER

$200,000/QALY

Cost per Remission

$13,000,000

Cost per Responder

$2,166,667

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+3%
Remission Rate
+0.5%
Common Side Effects
Diarrhea
+55%
Palmar-plantar erythrodysesthesia
+50%
Fatigue
+40%

Clinical Trial Phases:

Phase 3Phase 4