Condition

Liver cancer due to hepatitis C

Clinical trials and treatment information for Liver cancer due to hepatitis C

201K
People Affected
80
Active Trials
121K
New Cases/Year
147K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Liver Transplantation
95% Effectiveness• 95% Confidence• 40% Safety• 500 trials• 100K participants
HIGH EvidenceGood Value
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Comparative Safety Scale(Higher is safer)

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Meth💀
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40
DangerousModerateSafe

Time to Effect

Months to years for sustained benefit

Duration

Lifetime (immunosuppression)

Response Rate

%

Remission Rate

75%

Number Needed to Treat (NNT)

1

Common Side Effects:

Rejection: 20%
Infection: 60%
Kidney dysfunction: 30%
Cancer recurrence: 15%

Annual Cost of Care

Drug Cost

$15,000

Monitoring

$10,000

Side Effects

$7,500

Total Annual

$32,500

Cost-Effectiveness

GOOD

QALYs Gained

8

ICER

$150,000/QALY

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+95%
Remission Rate
+75%
Common Side Effects
Rejection
+20%
Infection
+60%
Kidney dysfunction
+30%

Clinical Trial Phases:

Phase 4
2
Surgical Resection
85% Effectiveness• 90% Confidence• 50% Safety• 500 trials• 100K participants
HIGH EvidenceGood Value
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Comparative Safety Scale(Higher is safer)

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50
DangerousModerateSafe

Time to Effect

Immediate (tumor removal), long-term survival benefit

Duration

One-time surgery, followed by surveillance

Response Rate

%

Remission Rate

60%

Number Needed to Treat (NNT)

2

Common Side Effects:

Postoperative liver failure: 7%
Bleeding: 15%
Infection: 10%
Recurrence: 50%

Annual Cost of Care

Drug Cost

$0

Monitoring

$3,500

Side Effects

$2,000

Total Annual

$5,500

Cost-Effectiveness

GOOD

QALYs Gained

5

ICER

$100,000/QALY

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+85%
Remission Rate
+60%
Common Side Effects
Postoperative liver failure
+7%
Bleeding
+15%
Infection
+10%

Clinical Trial Phases:

Phase 4
3
Radiofrequency Ablation (RFA)
80% Effectiveness• 88% Confidence• 65% Safety• 200 trials• 50K participants
HIGH EvidenceExcellent Value
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
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65
DangerousModerateSafe

Time to Effect

Immediate (tumor destruction)

Duration

One-time procedure, may require repeat, followed by surveillance

Response Rate

%

Remission Rate

70%

Common Side Effects:

Pain: 40%
Fever: 30%
Bleeding: 3%
Infection: 2%

Annual Cost of Care

Drug Cost

$0

Monitoring

$3,000

Side Effects

$750

Total Annual

$3,750

Cost-Effectiveness

EXCELLENT

QALYs Gained

4

ICER

$60,000/QALY

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+80%
Remission Rate
+70%
Common Side Effects
Pain
+40%
Fever
+30%
Bleeding
+3%

Clinical Trial Phases:

Phase 4
4
Atezolizumab + Bevacizumab
78% Effectiveness• 92% Confidence• 45% Safety• 50 trials• 10K participants
HIGH EvidenceModerate ValueDose: Atezolizumab 1200 mg IV every 3 weeks; Bevacizumab 15 mg/kg IV every 3 weeks
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
45
DangerousModerateSafe

Time to Effect

1-2 months

Duration

Until disease progression or unacceptable toxicity

Response Rate

27.3%

Remission Rate

%

Number Needed to Treat (NNT)

4

Common Side Effects:

Hypertension: 25%
Fatigue: 25%
Diarrhea: 18%
Hemorrhage: 7%
Immune-related hepatitis: 4%

Annual Cost of Care

Drug Cost

$215,000

Monitoring

$15,000

Side Effects

$10,000

Total Annual

$240,000

Cost-Effectiveness

MODERATE

QALYs Gained

1.2

ICER

$190,000/QALY

Cost per Responder

$879,121

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+78%
Response Rate
+27.3%
Common Side Effects
Hypertension
+25%
Fatigue
+25%
Diarrhea
+18%

Clinical Trial Phases:

Phase 3Phase 4
5
Lenvatinib
75% Effectiveness• 90% Confidence• 50% Safety• 30 trials• 8K participants
HIGH EvidenceGood ValueDose: 8 mg or 12 mg orally once daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
50
DangerousModerateSafe

Time to Effect

1-2 months

Duration

Until disease progression or unacceptable toxicity

Response Rate

24.1%

Remission Rate

%

Common Side Effects:

Hypertension: 45%
Fatigue: 35%
Diarrhea: 35%
Decreased appetite: 30%
Proteinuria: 20%

Annual Cost of Care

Drug Cost

$175,000

Monitoring

$7,500

Side Effects

$5,000

Total Annual

$187,500

Cost-Effectiveness

GOOD

QALYs Gained

0.6

ICER

$120,000/QALY

Cost per Responder

$778,008

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+24.1%
Common Side Effects
Hypertension
+45%
Fatigue
+35%
Diarrhea
+35%

Clinical Trial Phases:

Phase 3Phase 4
6
Transarterial Chemoembolization (TACE)
70% Effectiveness• 90% Confidence• 60% Safety• 100 trials• 30K participants
HIGH EvidenceGood Value
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe

Time to Effect

1-2 months

Duration

Multiple sessions (1-3+ per year), ongoing surveillance

Response Rate

60%

Remission Rate

%

Number Needed to Treat (NNT)

4

Common Side Effects:

Post-embolization syndrome (fever, pain, nausea): 70%
Liver dysfunction: 10%
Biloma/abscess: 2%

Annual Cost of Care

Drug Cost

$0

Monitoring

$7,500

Side Effects

$2,000

Total Annual

$9,500

Cost-Effectiveness

GOOD

QALYs Gained

1

ICER

$80,000/QALY

Cost per Responder

$15,833

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+60%
Common Side Effects
Post-embolization syndrome (fever, pain, nausea)
+70%
Liver dysfunction
+10%
Biloma/abscess
+2%

Clinical Trial Phases:

Phase 4