Sorafenib

Treatment for Liver cancer due to hepatitis B

Typical Dosage: 400 mg orally twice daily

Effectiveness
70%
Safety Score
30%
Clinical Trials
15
Participants
2.5K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
30
DangerousModerateSafe
Treatment Details
Dosage Range
400 mg orally twice daily
Time to Effect
1-3 months
Treatment Duration
until disease progression or unacceptable toxicity
Evidence Quality
HIGH
Number Needed to Treat (NNT)
12(Treat 12 patients to see 1 additional successful outcome)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$150,000
Monitoring:$15,000
Side Effect Mgmt:$5,000
Total Annual:$170,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
POOR
ICER
$180,000/QALY
QALYs Gained
0.4
Outcome-Based Costs
Cost per Responder
$5,666,667
Comparison vs Best Supportive Care
Cost Difference
+$170,000/year
More expensive
QALY Difference
+0.40 QALYs
Better outcomes
Dominance
No dominance
Sorafenib Outcomes

for Liver cancer due to hepatitis B

Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+3%
Remission Rate
+1%
Common Side Effects
Diarrhea
+55%
Palmar-plantar erythrodysesthesia (PPE)
+45%
Fatigue
+44%
Rash
+39%
Hypertension
+11%

Sources:

nih.gov
nih.gov
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov