Condition

Liver cancer due to hepatitis B

Clinical trials and treatment information for Liver cancer due to hepatitis B

288K
People Affected
80
Active Trials
173K
New Cases/Year
181K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Liver Transplantation
95% Effectiveness• 90% Confidence• 25% Safety• 50 trials• 10K participants
HIGH EvidenceModerate ValueDose: procedure-based, immunosuppressants lifelong
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Comparative Safety Scale(Higher is safer)

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25
DangerousModerateSafe

Time to Effect

immediate (tumor removal), long-term survival benefit

Duration

single surgery, lifelong immunosuppression

Response Rate

100%

Remission Rate

100%

Common Side Effects:

Surgical complications (bleeding, infection): 15%
Organ rejection: 20%
Kidney dysfunction (due to immunosuppressants): 30%
Increased infection risk: 40%
New-onset diabetes: 10%

Annual Cost of Care

Drug Cost

$15,000

Monitoring

$15,000

Side Effects

$10,000

Total Annual

$40,000

Cost-Effectiveness

MODERATE

QALYs Gained

8

ICER

$150,000/QALY

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+95%
Response Rate
+100%
Remission Rate
+100%
Common Side Effects
Surgical complications (bleeding, infection)
+15%
Organ rejection
+20%
Kidney dysfunction (due to immunosuppressants)
+30%

Clinical Trial Phases:

Phase 4
2
Radiofrequency Ablation (RFA)
90% Effectiveness• 90% Confidence• 40% Safety• 70 trials• 8K participants
HIGH EvidenceExcellent ValueDose: procedure-based
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Comparative Safety Scale(Higher is safer)

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40
DangerousModerateSafe

Time to Effect

immediate (tumor destruction)

Duration

single session, repeat if recurrence

Response Rate

90%

Remission Rate

90%

Common Side Effects:

Pain (local): 50%
Fever: 20%
Local bleeding/hematoma: 5%
Infection: 1%
Visceral injury: 1%

Annual Cost of Care

Drug Cost

$0

Monitoring

$7,000

Side Effects

$1,000

Total Annual

$8,000

Cost-Effectiveness

EXCELLENT

QALYs Gained

4.5

ICER

$40,000/QALY

Cost per Remission

$35,556

Cost per Responder

$35,556

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+90%
Remission Rate
+90%
Common Side Effects
Pain (local)
+50%
Fever
+20%
Local bleeding/hematoma
+5%

Clinical Trial Phases:

Phase 3Phase 4
3
Surgical Resection
90% Effectiveness• 85% Confidence• 25% Safety• 50 trials• 7K participants
HIGH EvidenceGood ValueDose: procedure-based
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Comparative Safety Scale(Higher is safer)

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25
DangerousModerateSafe

Time to Effect

immediate (tumor removal)

Duration

single surgery, then surveillance

Response Rate

100%

Remission Rate

100%

Common Side Effects:

Surgical complications (bleeding, infection): 15%
Liver failure (in cirrhotic patients): 10%
Ascites: 20%
Pleural effusion: 10%

Annual Cost of Care

Drug Cost

$0

Monitoring

$7,000

Side Effects

$1,000

Total Annual

$8,000

Cost-Effectiveness

GOOD

QALYs Gained

4

ICER

$80,000/QALY

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+100%
Remission Rate
+100%
Common Side Effects
Surgical complications (bleeding, infection)
+15%
Liver failure (in cirrhotic patients)
+10%
Ascites
+20%

Clinical Trial Phases:

Phase 4
4
Atezolizumab + Bevacizumab
85% Effectiveness• 95% Confidence• 30% Safety• 7 trials• 1.5K participants
HIGH EvidencePoor ValueDose: Atezolizumab 1200 mg IV q3w; Bevacizumab 15 mg/kg IV q3w
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Comparative Safety Scale(Higher is safer)

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30
DangerousModerateSafe

Time to Effect

1-3 months

Duration

until disease progression or unacceptable toxicity

Response Rate

30%

Remission Rate

8%

Common Side Effects:

Hypertension: 29%
Proteinuria: 10%
Bleeding: 24%
Fatigue: 40%
Diarrhea: 30%
Immune-related adverse events (e.g., hepatitis, rash): 20%

Annual Cost of Care

Drug Cost

$264,000

Monitoring

$15,000

Side Effects

$21,000

Total Annual

$300,000

Cost-Effectiveness

POOR

QALYs Gained

0.8

ICER

$350,000/QALY

Cost per Remission

$3,750,000

Cost per Responder

$1,000,000

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+30%
Remission Rate
+8%
Common Side Effects
Hypertension
+29%
Proteinuria
+10%
Bleeding
+24%

Clinical Trial Phases:

Phase 3
5
Lenvatinib
80% Effectiveness• 90% Confidence• 30% Safety• 8 trials• 1.2K participants
HIGH EvidencePoor ValueDose: 8-12 mg orally once daily
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Comparative Safety Scale(Higher is safer)

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30
DangerousModerateSafe

Time to Effect

1-3 months

Duration

until disease progression or unacceptable toxicity

Response Rate

24%

Remission Rate

1%

Common Side Effects:

Hypertension: 42%
Fatigue: 42%
Diarrhea: 39%
Decreased appetite: 34%
Weight loss: 31%
Palmar-plantar erythrodysesthesia (PPE): 30%
Proteinuria: 26%

Annual Cost of Care

Drug Cost

$216,000

Monitoring

$15,000

Side Effects

$9,000

Total Annual

$240,000

Cost-Effectiveness

POOR

QALYs Gained

0.6

ICER

$300,000/QALY

Cost per Responder

$1,000,000

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+24%
Remission Rate
+1%
Common Side Effects
Hypertension
+42%
Fatigue
+42%
Diarrhea
+39%

Clinical Trial Phases:

Phase 3
6
Transarterial Chemoembolization (TACE)
75% Effectiveness• 85% Confidence• 35% Safety• 50 trials• 10K participants
MODERATE EvidenceGood ValueDose: procedure-based
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Comparative Safety Scale(Higher is safer)

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35
DangerousModerateSafe

Time to Effect

1-2 months

Duration

1-3 sessions initially, repeated as needed (every 3-6 months)

Response Rate

60%

Remission Rate

20%

Number Needed to Treat (NNT)

7

Number Needed to Harm (NNH)

15

Common Side Effects:

Post-embolization syndrome (pain, fever, nausea): 80%
Liver dysfunction: 25%
Acute kidney injury: 5%
Severe complications (abscess, liver failure): 5%

Annual Cost of Care

Drug Cost

$0

Monitoring

$7,000

Side Effects

$3,000

Total Annual

$10,000

Cost-Effectiveness

GOOD

QALYs Gained

1

ICER

$80,000/QALY

Cost per Remission

$200,000

Cost per Responder

$66,667

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+60%
Remission Rate
+20%
Common Side Effects
Post-embolization syndrome (pain, fever, nausea)
+80%
Liver dysfunction
+25%
Acute kidney injury
+5%

Clinical Trial Phases:

Phase 3Phase 4
7
Sorafenib
70% Effectiveness• 90% Confidence• 30% Safety• 15 trials• 2.5K participants
HIGH EvidencePoor ValueDose: 400 mg orally twice daily
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Comparative Safety Scale(Higher is safer)

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30
DangerousModerateSafe

Time to Effect

1-3 months

Duration

until disease progression or unacceptable toxicity

Response Rate

3%

Remission Rate

1%

Number Needed to Treat (NNT)

12

Common Side Effects:

Diarrhea: 55%
Palmar-plantar erythrodysesthesia (PPE): 45%
Fatigue: 44%
Rash: 39%
Hypertension: 11%

Annual Cost of Care

Drug Cost

$150,000

Monitoring

$15,000

Side Effects

$5,000

Total Annual

$170,000

Cost-Effectiveness

POOR

QALYs Gained

0.4

ICER

$180,000/QALY

Cost per Responder

$5,666,667

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+3%
Remission Rate
+1%
Common Side Effects
Diarrhea
+55%
Palmar-plantar erythrodysesthesia (PPE)
+45%
Fatigue
+44%

Clinical Trial Phases:

Phase 3