Condition

Liver cancer due to alcohol use

Clinical trials and treatment information for Liver cancer due to alcohol use

132K
People Affected
80
Active Trials
79K
New Cases/Year
92K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Liver Transplantation
90% Effectivenessβ€’ 90% Confidenceβ€’ 35% Safetyβ€’ 500 trialsβ€’ 50K participants
HIGH EvidenceGood Value
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
35
DangerousModerateSafe

Time to Effect

Immediate tumor removal, long-term survival

Duration

Single surgery, lifelong immunosuppression

Response Rate

100%

Remission Rate

70%

Number Needed to Treat (NNT)

2

Number Needed to Harm (NNH)

10

Common Side Effects:

Surgical complications (bleeding, infection): 25%
Acute rejection: 15%
Immunosuppression-related infections: 30%
Kidney dysfunction: 15%
New-onset diabetes: 10%

Annual Cost of Care

Drug Cost

$20,000

Monitoring

$15,000

Side Effects

$10,000

Total Annual

$245,000

Cost-Effectiveness

GOOD

QALYs Gained

7

ICER

$65,000/QALY

Cost per Remission

$350,000

Cost per Responder

$245,000

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+100%
Remission Rate
+70%
Common Side Effects
Surgical complications (bleeding, infection)
+25%
Acute rejection
+15%
Immunosuppression-related infections
+30%

Clinical Trial Phases:

Phase 4
2
Surgical Resection
85% Effectivenessβ€’ 85% Confidenceβ€’ 25% Safetyβ€’ 300 trialsβ€’ 30K participants
MODERATE EvidenceModerate Value
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
25
DangerousModerateSafe

Time to Effect

Immediate tumor removal, long-term survival

Duration

Single surgery, long recovery and follow-up

Response Rate

100%

Remission Rate

60%

Number Needed to Treat (NNT)

3

Number Needed to Harm (NNH)

15

Common Side Effects:

Postoperative bleeding: 10%
Infection: 15%
Bile leak: 5%
Liver failure: 3%
Prolonged hospital stay: 15%

Annual Cost of Care

Drug Cost

$0

Monitoring

$60,000

Side Effects

$10,000

Total Annual

$76,000

Cost-Effectiveness

MODERATE

QALYs Gained

3

ICER

$100,000/QALY

Cost per Remission

$126,667

Cost per Responder

$76,000

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+100%
Remission Rate
+60%
Common Side Effects
Postoperative bleeding
+10%
Infection
+15%
Bile leak
+5%

Clinical Trial Phases:

Phase 4
3
Radiofrequency Ablation (RFA)
80% Effectivenessβ€’ 85% Confidenceβ€’ 70% Safetyβ€’ 50 trialsβ€’ 10K participants
HIGH EvidenceGood Value
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
70
DangerousModerateSafe

Time to Effect

Immediate tumor destruction, clinical outcome assessed within weeks

Duration

Single session, may be repeated for recurrence

Response Rate

80%

Remission Rate

65%

Number Needed to Treat (NNT)

4

Number Needed to Harm (NNH)

20

Common Side Effects:

Post-ablation syndrome (fever, pain): 30%
Bleeding: 3%
Infection: 1%
Thermal injury to adjacent organs: 1%

Annual Cost of Care

Drug Cost

$0

Monitoring

$18,000

Side Effects

$3,000

Total Annual

$21,000

Cost-Effectiveness

GOOD

QALYs Gained

1.5

ICER

$50,000/QALY

Cost per Remission

$32,308

Cost per Responder

$26,250

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+80%
Remission Rate
+65%
Common Side Effects
Post-ablation syndrome (fever, pain)
+30%
Bleeding
+3%
Infection
+1%

Clinical Trial Phases:

Phase 4
4
Transarterial Chemoembolization (TACE)
70% Effectivenessβ€’ 80% Confidenceβ€’ 65% Safetyβ€’ 100 trialsβ€’ 15K participants
HIGH EvidenceGood Value
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
65
DangerousModerateSafe

Time to Effect

Clinical benefit seen within weeks to months

Duration

Repeated every 1-3 months for several cycles

Response Rate

55%

Remission Rate

20%

Number Needed to Treat (NNT)

5

Number Needed to Harm (NNH)

15

Common Side Effects:

Post-embolization syndrome (fever, pain, nausea): 70%
Liver function abnormalities: 40%
Fatigue: 35%
Infection: 3%

Annual Cost of Care

Drug Cost

$0

Monitoring

$45,000

Side Effects

$5,000

Total Annual

$50,000

Cost-Effectiveness

GOOD

QALYs Gained

0.75

ICER

$80,000/QALY

Cost per Remission

$250,000

Cost per Responder

$90,909

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+55%
Remission Rate
+20%
Common Side Effects
Post-embolization syndrome (fever, pain, nausea)
+70%
Liver function abnormalities
+40%
Fatigue
+35%

Clinical Trial Phases:

Phase 4
5
Atezolizumab + Bevacizumab
65% Effectivenessβ€’ 90% Confidenceβ€’ 50% Safetyβ€’ 10 trialsβ€’ 2K participants
HIGH EvidencePoor ValueDose: Atezolizumab 1200mg IV Q3W + Bevacizumab 15mg/kg IV Q3W
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
50
DangerousModerateSafe

Time to Effect

Tumor response within 2-3 months

Duration

Until disease progression or unacceptable toxicity

Response Rate

30%

Remission Rate

3%

Common Side Effects:

Hypertension: 33%
Fatigue: 40%
Proteinuria: 15%
Diarrhea: 20%
Hemorrhage: 15%

Annual Cost of Care

Drug Cost

$357,000

Monitoring

$15,500

Side Effects

$7,500

Total Annual

$380,000

Cost-Effectiveness

POOR

QALYs Gained

0.6

ICER

$195,000/QALY

Cost per Remission

$12,666,667

Cost per Responder

$1,266,667

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+65%
Response Rate
+30%
Remission Rate
+3%
Common Side Effects
Hypertension
+33%
Fatigue
+40%
Proteinuria
+15%

Clinical Trial Phases:

Phase 3Phase 4
6
Lenvatinib
60% Effectivenessβ€’ 85% Confidenceβ€’ 55% Safetyβ€’ 5 trialsβ€’ 1.5K participants
HIGH EvidencePoor ValueDose: 8-12mg orally once daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
55
DangerousModerateSafe

Time to Effect

Tumor response within 1-3 months

Duration

Until disease progression or unacceptable toxicity

Response Rate

24%

Remission Rate

1%

Common Side Effects:

Hypertension: 42%
Fatigue: 41%
Diarrhea: 39%
Decreased appetite: 34%
Weight decrease: 31%
Hand-foot skin reaction: 27%

Annual Cost of Care

Drug Cost

$165,000

Monitoring

$12,000

Side Effects

$5,000

Total Annual

$182,000

Cost-Effectiveness

POOR

QALYs Gained

0.25

ICER

$180,000/QALY

Cost per Remission

$18,200,000

Cost per Responder

$758,333

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+24%
Remission Rate
+1%
Common Side Effects
Hypertension
+42%
Fatigue
+41%
Diarrhea
+39%

Clinical Trial Phases:

Phase 3Phase 4
7
Sorafenib
55% Effectivenessβ€’ 90% Confidenceβ€’ 55% Safetyβ€’ 8 trialsβ€’ 4.5K participants
HIGH EvidencePoor ValueDose: 400mg orally twice daily
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
55
DangerousModerateSafe

Time to Effect

Stable disease or response within 1-3 months

Duration

Until disease progression or unacceptable toxicity

Response Rate

3%

Remission Rate

1%

Number Needed to Treat (NNT)

8

Number Needed to Harm (NNH)

4

Common Side Effects:

Hand-foot skin reaction: 50%
Diarrhea: 45%
Fatigue: 35%
Rash: 25%
Hypertension: 15%

Annual Cost of Care

Drug Cost

$130,000

Monitoring

$12,000

Side Effects

$5,000

Total Annual

$147,000

Cost-Effectiveness

POOR

QALYs Gained

0.2

ICER

$200,000/QALY

Cost per Remission

$14,700,000

Cost per Responder

$4,900,000

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+55%
Response Rate
+3%
Remission Rate
+1%
Common Side Effects
Hand-foot skin reaction
+50%
Diarrhea
+45%
Fatigue
+35%

Clinical Trial Phases:

Phase 3Phase 4