Condition

Ischemic heart disease

Clinical trials and treatment information for Ischemic heart disease

254.3M
People Affected
300
Active Trials
5.1M
New Cases/Year
9M
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Atorvastatin
90% Effectiveness• 95% Confidence• 65% Safety• 186 trials• 200K participants
HIGH EvidenceExcellent ValueDose: 10-80mg daily
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe

Time to Effect

3-6 months

Duration

lifetime

Response Rate

80%

Remission Rate

%

Number Needed to Treat (NNT)

20

Number Needed to Harm (NNH)

1000

Common Side Effects:

Myalgia: 5%
Liver enzyme elevation: 2%
Headache: 3%

Annual Cost of Care

Drug Cost

$30

Monitoring

$150

Side Effects

$20

Total Annual

$200

Cost-Effectiveness

EXCELLENT

QALYs Gained

1.5

ICER

$10,000/QALY

Cost per Responder

$250

Treatment Outcomes
Primary Outcomes
LDL Cholesterol140 mg/dL
-45% (-63 mg/dL)
Total Cholesterol220 mg/dL
-35% (-77 mg/dL)
Triglycerides180 mg/dL
-25% (-45 mg/dL)
hs-CRP (High-sensitivity C-reactive protein)3.5 mg/L
-20% (-0.7 mg/L)
Secondary Benefits
HDL Cholesterol40 mg/dL
+7% (+2.8 mg/dL)
Angina Episodes per Week4 episodes/week
-25% (-1 episode/week)
Apolipoprotein B (ApoB)110 mg/dL
-35% (-38.5 mg/dL)
Common Side Effects
Myalgia
+5%
Liver enzyme elevation
+2%
Headache
+3%

Clinical Trial Phases:

Phase 4
2
Aspirin
85% Effectiveness• 98% Confidence• 80% Safety• 527 trials• 500K participants
HIGH EvidenceExcellent ValueDose: 75-100mg daily
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
80
DangerousModerateSafe

Time to Effect

immediate

Duration

lifetime

Response Rate

70%

Remission Rate

%

Number Needed to Treat (NNT)

40

Number Needed to Harm (NNH)

200

Common Side Effects:

Gastrointestinal bleeding: 1%
Dyspepsia: 10%

Annual Cost of Care

Drug Cost

$10

Monitoring

$50

Side Effects

$20

Total Annual

$80

Cost-Effectiveness

EXCELLENT

QALYs Gained

1

ICER

$5,000/QALY

Cost per Responder

$114

Treatment Outcomes
Primary Outcomes
Risk of Major Adverse Cardiovascular Events (MACE)Baseline annual MACE rate: 10%
-19% (-1.9 percentage points (e.g., from 10% to 8.1%))
Risk of Non-fatal Myocardial InfarctionBaseline annual Non-fatal MI rate: 6%
-25% (-1.5 percentage points (e.g., from 6% to 4.5%))
Risk of Non-fatal Ischemic StrokeBaseline annual Non-fatal Ischemic Stroke rate: 3%
-22% (-0.66 percentage points (e.g., from 3% to 2.34%))
Risk of Cardiovascular DeathBaseline annual Cardiovascular Death rate: 4%
-12% (-0.48 percentage points (e.g., from 4% to 3.52%))
Secondary Benefits
Risk of Hospitalization for Unstable AnginaBaseline annual hospitalization for Unstable Angina rate: 5%
-20% (-1.0 percentage point (e.g., from 5% to 4%))
Risk of All-cause MortalityBaseline annual All-cause Mortality rate: 8%
-10% (-0.8 percentage points (e.g., from 8% to 7.2%))
Risk of Urgent Coronary RevascularizationBaseline annual urgent revascularization rate: 7%
-15% (-1.05 percentage points (e.g., from 7% to 5.95%))
Common Side Effects
Gastrointestinal bleeding
+1%
Dyspepsia
+10%

Clinical Trial Phases:

Phase 4
3
Lisinopril
80% Effectiveness• 92% Confidence• 70% Safety• 11 trials• 150K participants
HIGH EvidenceExcellent ValueDose: 5-40mg daily
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

1-2 weeks

Duration

lifetime

Response Rate

75%

Remission Rate

%

Number Needed to Treat (NNT)

30

Number Needed to Harm (NNH)

500

Common Side Effects:

Cough: 15%
Hypotension: 5%
Hyperkalemia: 3%

Annual Cost of Care

Drug Cost

$20

Monitoring

$100

Side Effects

$20

Total Annual

$140

Cost-Effectiveness

EXCELLENT

QALYs Gained

1.2

ICER

$15,000/QALY

Cost per Responder

$187

Treatment Outcomes
Primary Outcomes
Systolic Blood Pressure140 mmHg
-10% (-14 mmHg)
Diastolic Blood Pressure90 mmHg
-11.1% (-10 mmHg)
Left Ventricular Ejection Fraction45%
+8.9% (+4 percentage points)
NT-proBNP1200 pg/mL
-25% (-300 pg/mL)
Secondary Benefits
Angina Episodes per Week5 episodes/week
-30% (-1.5 episodes/week)
6-Minute Walk Distance350 meters
+10% (+35 meters)
Quality of Life Score (EQ-5D VAS)65/100
+7.7% (+5 points)
Common Side Effects
Cough
+15%
Hypotension
+5%
Hyperkalemia
+3%

Clinical Trial Phases:

Phase 4
4
Metoprolol
78% Effectiveness• 90% Confidence• 70% Safety• 47 trials• 120K participants
HIGH EvidenceExcellent ValueDose: 25-200mg daily
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

immediate

Duration

lifetime

Response Rate

70%

Remission Rate

%

Number Needed to Treat (NNT)

40

Number Needed to Harm (NNH)

300

Common Side Effects:

Bradycardia: 10%
Fatigue: 15%
Hypotension: 8%

Annual Cost of Care

Drug Cost

$25

Monitoring

$100

Side Effects

$20

Total Annual

$145

Cost-Effectiveness

EXCELLENT

QALYs Gained

1

ICER

$20,000/QALY

Cost per Responder

$207

Treatment Outcomes
Primary Outcomes
Resting Heart Rate78 bpm
-18% (-14 bpm)
Angina Attacks per Week4.5 attacks/week
-40% (-1.8 attacks/week)
Exercise Time to Angina Onset6.5 minutes
+15% (+1.0 minute)
Systolic Blood Pressure142 mmHg
-12% (-17 mmHg)
Secondary Benefits
Diastolic Blood Pressure88 mmHg
-10% (-9 mmHg)
Nitroglycerin Tablet Use per Week3.0 tablets/week
-45% (-1.4 tablets/week)
Seattle Angina Questionnaire (SAQ) Physical Limitation Score55/100 points
+15% (+8 points)
Common Side Effects
Bradycardia
+10%
Fatigue
+15%
Hypotension
+8%

Clinical Trial Phases:

Phase 4
5
Clopidogrel
75% Effectiveness• 90% Confidence• 70% Safety• 592 trials• 100K participants
HIGH EvidenceGood ValueDose: 75mg daily
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

2-7 days

Duration

6-12 months (post-ACS/PCI) or lifetime

Response Rate

65%

Remission Rate

%

Number Needed to Treat (NNT)

60

Number Needed to Harm (NNH)

150

Common Side Effects:

Bleeding: 5%
Dyspepsia: 6%

Annual Cost of Care

Drug Cost

$50

Monitoring

$80

Side Effects

$30

Total Annual

$160

Cost-Effectiveness

GOOD

QALYs Gained

0.8

ICER

$40,000/QALY

Cost per Responder

$246

Treatment Outcomes
Primary Outcomes
Major Adverse Cardiovascular Events (MACE)Event rate: 10.0% over 1 year
-20% (-2.0 percentage points)
Non-fatal Myocardial InfarctionEvent rate: 5.0% over 1 year
-20% (-1.0 percentage point)
Non-fatal Ischemic StrokeEvent rate: 2.0% over 1 year
-25% (-0.5 percentage point)
Cardiovascular DeathEvent rate: 3.0% over 1 year
-10% (-0.3 percentage point)
Secondary Benefits
Re-hospitalization for Ischemic EventsEvent rate: 15.0% over 1 year
-15% (-2.25 percentage points)
Urgent Revascularization (PCI/CABG)Event rate: 8.0% over 1 year
-18% (-1.44 percentage points)
Platelet Aggregation (ADP-induced)75% aggregation (at 5µM ADP)
-50% (-37.5% aggregation)
Common Side Effects
Bleeding
+5%
Dyspepsia
+6%

Clinical Trial Phases:

Phase 4
6
Isosorbide Mononitrate
60% Effectiveness• 85% Confidence• 70% Safety• 21 trials• 30K participants
MODERATE EvidenceGood ValueDose: 20-120mg daily
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

30-60 minutes

Duration

lifetime

Response Rate

85%

Remission Rate

%

Number Needed to Treat (NNT)

5

Number Needed to Harm (NNH)

50

Common Side Effects:

Headache: 25%
Hypotension: 10%
Dizziness: 5%

Annual Cost of Care

Drug Cost

$30

Monitoring

$50

Side Effects

$25

Total Annual

$105

Cost-Effectiveness

GOOD

QALYs Gained

0.5

Cost per Responder

$124

Treatment Outcomes
Primary Outcomes
Angina Attack Frequency5 attacks/week
-60% (-3 attacks/week)
Nitroglycerin Tablet Consumption4 tablets/week
-50% (-2 tablets/week)
Exercise Tolerance Time (Time to Onset of Angina)6 minutes on treadmill
+25% (+1.5 minutes)
Secondary Benefits
Seattle Angina Questionnaire (SAQ) Angina Frequency Score50 points (0-100 scale)
+20% (+10 points)
Systolic Blood Pressure135 mmHg
-7.4% (-10 mmHg)
Diastolic Blood Pressure85 mmHg
-5.9% (-5 mmHg)
Common Side Effects
Headache
+25%
Hypotension
+10%
Dizziness
+5%

Clinical Trial Phases:

Phase 4