Tricyclic Antidepressants (TCAs)

Treatment for Irritable Bowel Syndrome

Typical Dosage: 10-50 mg orally daily (e.g., Amitriptyline)

Effectiveness
55%
Safety Score
60%
Clinical Trials
30
Participants
4K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
10-50 mg orally daily (e.g., Amitriptyline)
Time to Effect
2-4 weeks
Treatment Duration
Long-term (chronic)
Evidence Quality
MODERATE
Number Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
5(Treat 5 patients to see 1 additional serious adverse event)
Confidence Score
80%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$50
Monitoring:$150
Side Effect Mgmt:$100
Total Annual:$300
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
ICER
$10,000/QALY
QALYs Gained
0.1
Outcome-Based Costs
Cost per Responder
$750
Cost per Remission
$2,000
Comparison vs Placebo
Cost Difference
+$250/year
More expensive
QALY Difference
+0.08 QALYs
Better outcomes
Dominance
No dominance
Tricyclic Antidepressants (TCAs) Outcomes

for Irritable Bowel Syndrome

Efficacy Outcomes
Overall Effectiveness
+55%
Response Rate
+40%
Remission Rate
+15%
Common Side Effects
Dry mouth
+25%
Constipation
+20%
Sedation
+15%
Dizziness
+10%

Sources:

semanticscholar.org
nih.gov
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov