Condition

Invasive Non-typhoidal Salmonella (iNTS)

Clinical trials and treatment information for Invasive Non-typhoidal Salmonella (iNTS)

600K
People Affected
80
Active Trials
535K
New Cases/Year
62K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Meropenem
95% Effectivenessβ€’ 85% Confidenceβ€’ 65% Safetyβ€’ 80 trialsβ€’ 8K participants
MODERATE EvidenceGood ValueDose: 1g IV every 8 hours
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
65
DangerousModerateSafe

Time to Effect

1-2 days

Duration

7-14 days

Response Rate

95%

Remission Rate

95%

Common Side Effects:

Diarrhea: 4%
Nausea/Vomiting: 3%
Injection site reactions: 2%
Seizures: 0.1%

Annual Cost of Care

Drug Cost

$2,000

Monitoring

$1,000

Side Effects

$100

Total Annual

$3,100

Cost-Effectiveness

GOOD

QALYs Gained

0.25

Cost per Remission

$3,263

Cost per Responder

$3,263

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+95%
Response Rate
+95%
Remission Rate
+95%
Common Side Effects
Diarrhea
+4%
Nausea/Vomiting
+3%
Injection site reactions
+2%

Clinical Trial Phases:

Phase 4
2
Ceftriaxone
90% Effectivenessβ€’ 90% Confidenceβ€’ 70% Safetyβ€’ 300 trialsβ€’ 30K participants
HIGH EvidenceExcellent ValueDose: 1-2g IV/IM daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
70
DangerousModerateSafe

Time to Effect

2-3 days

Duration

7-14 days

Response Rate

90%

Remission Rate

90%

Common Side Effects:

Diarrhea: 5%
Injection site pain: 3%
Rash: 1%

Annual Cost of Care

Drug Cost

$150

Monitoring

$500

Side Effects

$50

Total Annual

$700

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.2

Cost per Remission

$778

Cost per Responder

$778

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+90%
Remission Rate
+90%
Common Side Effects
Diarrhea
+5%
Injection site pain
+3%
Rash
+1%

Clinical Trial Phases:

Phase 4
3
Ciprofloxacin
85% Effectivenessβ€’ 90% Confidenceβ€’ 70% Safetyβ€’ 250 trialsβ€’ 25K participants
HIGH EvidenceExcellent ValueDose: 500-750mg orally twice daily or 400mg IV twice daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
70
DangerousModerateSafe

Time to Effect

1-2 days

Duration

7-14 days

Response Rate

85%

Remission Rate

85%

Common Side Effects:

Nausea: 4%
Diarrhea: 3%
Headache: 2%
Tendinopathy/Tendon rupture: 0.1%

Annual Cost of Care

Drug Cost

$50

Monitoring

$500

Side Effects

$50

Total Annual

$600

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.2

Cost per Remission

$706

Cost per Responder

$706

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+85%
Remission Rate
+85%
Common Side Effects
Nausea
+4%
Diarrhea
+3%
Headache
+2%

Clinical Trial Phases:

Phase 4
4
Azithromycin
80% Effectivenessβ€’ 85% Confidenceβ€’ 70% Safetyβ€’ 150 trialsβ€’ 15K participants
MODERATE EvidenceExcellent ValueDose: 500mg orally daily for 7-14 days
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
70
DangerousModerateSafe

Time to Effect

3-5 days

Duration

7-14 days

Response Rate

80%

Remission Rate

80%

Common Side Effects:

Diarrhea: 7%
Nausea: 5%
Abdominal pain: 3%
QT prolongation: 0.1%

Annual Cost of Care

Drug Cost

$40

Monitoring

$500

Side Effects

$50

Total Annual

$590

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.18

Cost per Remission

$738

Cost per Responder

$738

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+80%
Response Rate
+80%
Remission Rate
+80%
Common Side Effects
Diarrhea
+7%
Nausea
+5%
Abdominal pain
+3%

Clinical Trial Phases:

Phase 4
5
Trimethoprim-Sulfamethoxazole (TMP-SMX)
75% Effectivenessβ€’ 80% Confidenceβ€’ 70% Safetyβ€’ 100 trialsβ€’ 10K participants
MODERATE EvidenceExcellent ValueDose: 160mg TMP/800mg SMX orally twice daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
MethπŸ’€
Cigarettes🚬
Chemo☒️
Alcohol🍺
MorphineπŸ’Š
AntibioticsπŸ’‰
TylenolπŸ’Š
ExerciseπŸƒ
WaterπŸ’§
70
DangerousModerateSafe

Time to Effect

3-5 days

Duration

7-14 days

Response Rate

75%

Remission Rate

75%

Common Side Effects:

Nausea/Vomiting: 4%
Rash: 5%
Photosensitivity: 2%
Hyperkalemia: 1%

Annual Cost of Care

Drug Cost

$30

Monitoring

$500

Side Effects

$50

Total Annual

$580

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.15

Cost per Remission

$773

Cost per Responder

$773

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+75%
Remission Rate
+75%
Common Side Effects
Nausea/Vomiting
+4%
Rash
+5%
Photosensitivity
+2%

Clinical Trial Phases:

Phase 4