Osmotic Therapy (Mannitol or Hypertonic Saline)

Treatment for Intracerebral hemorrhage

Typical Dosage: Mannitol (0.25-1 g/kg IV), Hypertonic Saline (e.g., 3% NaCl 100-250ml IV bolus)

Effectiveness
85%
Safety Score
60%
Clinical Trials
40
Participants
6K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
Mannitol (0.25-1 g/kg IV), Hypertonic Saline (e.g., 3% NaCl 100-250ml IV bolus)
Time to Effect
Minutes
Treatment Duration
Hours to days
Evidence Quality
MODERATE
Number Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
20(Treat 20 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$500
Monitoring:$200
Side Effect Mgmt:$100
Total Annual:$800
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
ICER
$10,000/QALY
QALYs Gained
1
Outcome-Based Costs
Cost per Responder
$1,000
Osmotic Therapy (Mannitol or Hypertonic Saline) Outcomes

for Intracerebral hemorrhage

Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+80%
Common Side Effects
Electrolyte imbalance (e.g., hypernatremia)
+15%
Renal dysfunction (with Mannitol)
+5%
Hypotension
+3%

Sources:

nih.gov
researchgate.net
unifesp.br

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov