Condition

Hypertensive heart disease

Clinical trials and treatment information for Hypertensive heart disease

12.5M
People Affected
300
Active Trials
375K
New Cases/Year
1.3M
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Spironolactone (MRA)
89% Effectiveness• 90% Confidence• 65% Safety• 500 trials• 50K participants
HIGH EvidenceExcellent ValueDose: 12.5mg - 50mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
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Morphine💊
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65
DangerousModerateSafe

Time to Effect

Weeks for BP effect, months for mortality benefit

Duration

lifetime

Response Rate

65%

Remission Rate

%

Number Needed to Treat (NNT)

8

Number Needed to Harm (NNH)

10

Common Side Effects:

Hyperkalemia: 15%
Gynecomastia: 10%
Dizziness: 5%

Annual Cost of Care

Drug Cost

$30

Monitoring

$600

Side Effects

$100

Total Annual

$730

Cost-Effectiveness

EXCELLENT

QALYs Gained

3

ICER

$8,000/QALY

Cost per Responder

$1,123.08

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+89%
Response Rate
+65%
Common Side Effects
Hyperkalemia
+15%
Gynecomastia
+10%
Dizziness
+5%

Clinical Trial Phases:

Phase 4
2
Lisinopril (ACE Inhibitor)
88% Effectiveness• 95% Confidence• 70% Safety• 2 trials• 1M participants
HIGH EvidenceExcellent ValueDose: 2.5mg - 40mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

2-4 weeks for full BP effect, months for cardiac remodeling

Duration

lifetime

Response Rate

75%

Remission Rate

%

Number Needed to Treat (NNT)

15

Number Needed to Harm (NNH)

10

Common Side Effects:

Cough: 20%
Dizziness: 10%
Hyperkalemia: 5%
Angioedema: 0.7%

Annual Cost of Care

Drug Cost

$30

Monitoring

$300

Side Effects

$75

Total Annual

$405

Cost-Effectiveness

EXCELLENT

QALYs Gained

2.5

ICER

$20,000/QALY

Cost per Responder

$540

Treatment Outcomes
Primary Outcomes
Systolic Blood Pressure155 mmHg
-9.7% (-15 mmHg)
Diastolic Blood Pressure98 mmHg
-8.2% (-8 mmHg)
Left Ventricular Mass Index125 g/m²
-12% (-15 g/m²)
Urine Albumin-to-Creatinine Ratio75 mg/g
-40% (-30 mg/g)
Secondary Benefits
NYHA Functional ClassNYHA Class III (score 3)
-33.33% (-1 class unit (e.g., from Class III to Class II))
B-type Natriuretic Peptide (BNP)450 pg/mL
-30% (-135 pg/mL)
EQ-5D Visual Analogue Scale Score60/100 points
+11.7% (+7 points)
Common Side Effects
Cough
+20%
Dizziness
+10%
Hyperkalemia
+5%

Clinical Trial Phases:

Phase 4
3
Hydrochlorothiazide (Thiazide Diuretic)
87% Effectiveness• 96% Confidence• 70% Safety• 1 trials• 1.5M participants
HIGH EvidenceExcellent ValueDose: 12.5mg - 50mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

2-4 weeks for full BP effect

Duration

lifetime

Response Rate

80%

Remission Rate

%

Number Needed to Treat (NNT)

12

Number Needed to Harm (NNH)

15

Common Side Effects:

Hypokalemia: 10%
Dizziness: 5%
Hyperuricemia: 10%
Hyperglycemia: 5%

Annual Cost of Care

Drug Cost

$20

Monitoring

$350

Side Effects

$50

Total Annual

$420

Cost-Effectiveness

EXCELLENT

QALYs Gained

2.6

ICER

$5,000/QALY

Cost per Responder

$525

Treatment Outcomes
Primary Outcomes
Systolic Blood Pressure150 mmHg
-10% (-15 mmHg)
Diastolic Blood Pressure95 mmHg
-8.4% (-8 mmHg)
Left Ventricular Mass Index130 g/m²
-8% (-10.4 g/m²)
Secondary Benefits
Serum Potassium4.0 mEq/L
-12.5% (-0.5 mEq/L)
Serum Creatinine0.9 mg/dL
+5.6% (+0.05 mg/dL)
Fasting Blood Glucose95 mg/dL
+7.4% (+7 mg/dL)
Common Side Effects
Hypokalemia
+10%
Dizziness
+5%
Hyperuricemia
+10%

Clinical Trial Phases:

Phase 4
4
Valsartan (ARB)
87% Effectiveness• 93% Confidence• 70% Safety• 2 trials• 500K participants
HIGH EvidenceExcellent ValueDose: 40mg - 320mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

2-4 weeks for full BP effect, months for cardiac remodeling

Duration

lifetime

Response Rate

72%

Remission Rate

%

Number Needed to Treat (NNT)

18

Number Needed to Harm (NNH)

40

Common Side Effects:

Dizziness: 5%
Hyperkalemia: 4%
Angioedema: 0.1%

Annual Cost of Care

Drug Cost

$100

Monitoring

$300

Side Effects

$75

Total Annual

$475

Cost-Effectiveness

EXCELLENT

QALYs Gained

2.4

ICER

$25,000/QALY

Cost per Responder

$659.72

Treatment Outcomes
Primary Outcomes
Systolic Blood Pressure150 mmHg
-10% (-15 mmHg)
Diastolic Blood Pressure95 mmHg
-8.4% (-8 mmHg)
Left Ventricular Mass Index (LVMI)120 g/m²
-12.5% (-15 g/m²)
NT-proBNP300 pg/mL
-15% (-45 pg/mL)
Secondary Benefits
Echocardiographic E/A Ratio0.8
+12.5% (+0.1)
Kansas City Cardiomyopathy Questionnaire (KCCQ) Overall Summary Score60/100 points
+13.3% (+8 points)
Urine Albumin-to-Creatinine Ratio (UACR)80 mg/g
-30% (-24 mg/g)
Common Side Effects
Dizziness
+5%
Hyperkalemia
+4%
Angioedema
+0.1%

Clinical Trial Phases:

Phase 4
5
Amlodipine (Dihydropyridine CCB)
86% Effectiveness• 94% Confidence• 70% Safety• 2 trials• 800K participants
HIGH EvidenceExcellent ValueDose: 2.5mg - 10mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

1-2 weeks for full BP effect, months for cardiac remodeling

Duration

lifetime

Response Rate

78%

Remission Rate

%

Number Needed to Treat (NNT)

20

Number Needed to Harm (NNH)

15

Common Side Effects:

Peripheral edema: 15%
Headache: 8%
Flushing: 5%

Annual Cost of Care

Drug Cost

$40

Monitoring

$300

Side Effects

$75

Total Annual

$415

Cost-Effectiveness

EXCELLENT

QALYs Gained

2.3

ICER

$22,000/QALY

Cost per Responder

$532.05

Treatment Outcomes
Primary Outcomes
Systolic Blood Pressure158 mmHg
-15.8% (-25 mmHg)
Diastolic Blood Pressure96 mmHg
-10.4% (-10 mmHg)
Left Ventricular Mass Index (LVMI)125 g/m^2
-12% (-15 g/m^2)
Secondary Benefits
Mean 24-hour Systolic Blood Pressure (ABPM)145 mmHg
-10.3% (-15 mmHg)
Angina Episode Frequency4 episodes/week
-60% (-2.4 episodes/week)
Left Atrial Volume Index (LAVI)38 mL/m^2
-10% (-3.8 mL/m^2)
Common Side Effects
Peripheral edema
+15%
Headache
+8%
Flushing
+5%

Clinical Trial Phases:

Phase 4
6
Metoprolol Succinate (Beta-blocker)
85% Effectiveness• 92% Confidence• 70% Safety• 1000 trials• 400K participants
HIGH EvidenceExcellent ValueDose: 25mg - 200mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

1-2 weeks for full BP effect, months for cardiac remodeling

Duration

lifetime

Response Rate

70%

Remission Rate

%

Number Needed to Treat (NNT)

12

Number Needed to Harm (NNH)

15

Common Side Effects:

Fatigue/weakness: 10%
Bradycardia: 5%
Dizziness: 5%
Erectile dysfunction: 10%

Annual Cost of Care

Drug Cost

$50

Monitoring

$300

Side Effects

$75

Total Annual

$425

Cost-Effectiveness

EXCELLENT

QALYs Gained

2.2

ICER

$18,000/QALY

Cost per Responder

$607.14

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+85%
Response Rate
+70%
Common Side Effects
Fatigue/weakness
+10%
Bradycardia
+5%
Dizziness
+5%

Clinical Trial Phases:

Phase 4