Condition

Hypertension

High blood pressure

1.4B
People Affected
1,795
Active Trials
70M
New Cases/Year
10M
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Chlorthalidone
90% Effectiveness• 95% Confidence• 70% Safety• 89 trials• 500K participants
HIGH EvidenceExcellent ValueDose: 12.5-25mg daily
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

1-3 weeks

Duration

lifetime

Response Rate

60%

Remission Rate

%

Number Needed to Treat (NNT)

30

Number Needed to Harm (NNH)

15

Common Side Effects:

Hypokalemia: 10%
Hyperuricemia: 7%
Dizziness/Orthostatic Hypotension: 5%
Hyponatremia: 3%

Annual Cost of Care

Drug Cost

$20

Monitoring

$150

Side Effects

$50

Total Annual

$220

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.5

ICER

$5,000/QALY

Cost per Responder

$367

Treatment Outcomes
Primary Outcomes
Systolic Blood Pressure150 mmHg
-10% (-15 mmHg)
Diastolic Blood Pressure95 mmHg
-8.4% (-8 mmHg)
Left Ventricular Mass Index110 g/m²
-12% (-13.2 g/m²)
Secondary Benefits
Quality of Life (EQ-5D VAS)70/100
+5% (+3.5 points)
Urinary Calcium Excretion250 mg/24h
-20% (-50 mg/24h)
Pulse Pressure55 mmHg
-12.7% (-7 mmHg)
Common Side Effects
Hypokalemia
+10%
Hyperuricemia
+7%
Dizziness/Orthostatic Hypotension
+5%

Clinical Trial Phases:

Phase 4
2
Lisinopril
88% Effectiveness• 95% Confidence• 70% Safety• 80 trials• 500K participants
HIGH EvidenceExcellent ValueDose: 10-40mg daily
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

1-2 weeks

Duration

lifetime

Response Rate

60%

Remission Rate

%

Number Needed to Treat (NNT)

35

Number Needed to Harm (NNH)

10

Common Side Effects:

Cough: 15%
Dizziness/Orthostatic Hypotension: 5%
Hyperkalemia: 3%
Angioedema: 0.1%

Annual Cost of Care

Drug Cost

$20

Monitoring

$150

Side Effects

$50

Total Annual

$220

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.5

ICER

$7,000/QALY

Cost per Responder

$367

Treatment Outcomes
Primary Outcomes
Systolic Blood Pressure (SBP)155 mmHg
-9.7% (-15 mmHg)
Diastolic Blood Pressure (DBP)98 mmHg
-8.2% (-8 mmHg)
Left Ventricular Mass Index (LVMI)100 g/m2
-12% (-12 g/m2)
Secondary Benefits
Urinary Albumin-to-Creatinine Ratio (UACR)60 mg/g
-35% (-21 mg/g)
Pulse Pressure60 mmHg
-11.7% (-7 mmHg)
Common Side Effects
Cough
+15%
Dizziness/Orthostatic Hypotension
+5%
Hyperkalemia
+3%

Clinical Trial Phases:

Phase 4
3
Amlodipine
87% Effectiveness• 95% Confidence• 70% Safety• 540 trials• 400K participants
HIGH EvidenceExcellent ValueDose: 2.5-10mg daily
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

1-2 weeks

Duration

lifetime

Response Rate

60%

Remission Rate

%

Number Needed to Treat (NNT)

40

Number Needed to Harm (NNH)

8

Common Side Effects:

Peripheral edema: 15%
Headache: 10%
Flushing: 5%
Dizziness: 3%

Annual Cost of Care

Drug Cost

$20

Monitoring

$100

Side Effects

$50

Total Annual

$170

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.5

ICER

$8,000/QALY

Cost per Responder

$283

Treatment Outcomes
Primary Outcomes
Systolic Blood Pressure155 mmHg
-9.7% (-15 mmHg)
Diastolic Blood Pressure98 mmHg
-8.2% (-8 mmHg)
Pulse Pressure57 mmHg
-12.3% (-7 mmHg)
Secondary Benefits
Left Ventricular Mass Index125 g/m^2
-12% (-15 g/m^2)
Urine Albumin-to-Creatinine Ratio (UACR)50 mg/g
-25% (-12.5 mg/g)
EQ-5D Health-related Quality of Life Score0.75
+5% (+0.04 points)
Common Side Effects
Peripheral edema
+15%
Headache
+10%
Flushing
+5%

Clinical Trial Phases:

Phase 4
4
Valsartan
86% Effectiveness• 95% Confidence• 70% Safety• 258 trials• 350K participants
HIGH EvidenceGood ValueDose: 80-320mg daily
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

1-2 weeks

Duration

lifetime

Response Rate

60%

Remission Rate

%

Number Needed to Treat (NNT)

45

Common Side Effects:

Dizziness/Orthostatic Hypotension: 5%
Hyperkalemia: 3%
Renal impairment: 2%
Angioedema: 0.05%

Annual Cost of Care

Drug Cost

$30

Monitoring

$150

Side Effects

$50

Total Annual

$230

Cost-Effectiveness

GOOD

QALYs Gained

0.5

ICER

$10,000/QALY

Cost per Responder

$383

Treatment Outcomes
Primary Outcomes
Office Systolic Blood Pressure (SBP)150 mmHg
-10% (-15 mmHg)
Office Diastolic Blood Pressure (DBP)95 mmHg
-8.4% (-8 mmHg)
24-hour Ambulatory Systolic Blood Pressure (ASBP)145 mmHg
-8.3% (-12 mmHg)
Secondary Benefits
Left Ventricular Mass Index (LVMI)110 g/m^2
-12% (-13 g/m^2)
Urinary Albumin Excretion Rate (UAER)150 mg/24h
-25% (-38 mg/24h)
Health-Related Quality of Life (EQ-5D Index)0.85
+4.7% (+0.04 points)
Common Side Effects
Dizziness/Orthostatic Hypotension
+5%
Hyperkalemia
+3%
Renal impairment
+2%

Clinical Trial Phases:

Phase 4
5
Metoprolol
80% Effectiveness• 90% Confidence• 65% Safety• 83 trials• 300K participants
HIGH EvidenceGood ValueDose: 25-200mg daily (extended release)
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe

Time to Effect

1-2 weeks

Duration

lifetime

Response Rate

50%

Remission Rate

%

Number Needed to Treat (NNT)

50

Number Needed to Harm (NNH)

15

Common Side Effects:

Fatigue: 15%
Bradycardia: 8%
Dizziness: 7%
Erectile dysfunction: 5%

Annual Cost of Care

Drug Cost

$30

Monitoring

$100

Side Effects

$75

Total Annual

$205

Cost-Effectiveness

GOOD

QALYs Gained

0.45

ICER

$12,000/QALY

Cost per Responder

$410

Treatment Outcomes
Primary Outcomes
Systolic Blood Pressure150 mmHg
-8% (-12 mmHg)
Diastolic Blood Pressure95 mmHg
-8.4% (-8 mmHg)
Resting Heart Rate78 bpm
-19.2% (-15 bpm)
Secondary Benefits
Left Ventricular Mass Index135 g/m^2
-14.8% (-20 g/m^2)
Frequency of Angina Episodes4 episodes/week
-50% (-2 episodes/week)
Patient Global Assessment of Well-being (VAS 0-100)60/100
+13.3% (+8 points)
Common Side Effects
Fatigue
+15%
Bradycardia
+8%
Dizziness
+7%

Clinical Trial Phases:

Phase 4