Gentamicin + Azithromycin (Dual Therapy for Cephalosporin Allergy)
Treatment for Gonococcal infection
Typical Dosage: Gentamicin 240mg IM + Azithromycin 2g oral
Effectiveness
95%
Safety Score
68%
Clinical Trials
25
Participants
3.5K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
68
DangerousModerateSafe
Treatment Details
Dosage Range
Gentamicin 240mg IM + Azithromycin 2g oral
Time to Effect
1-3 days
Treatment Duration
Single dose
Evidence Quality
MODERATENumber Needed to Treat (NNT)
1.2(Treat 1.2 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
5(Treat 5 patients to see 1 additional serious adverse event)
Confidence Score
85%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$55
Monitoring:$150
Side Effect Mgmt:$50
Total Annual:$255
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOODQALYs Gained
0.05
Outcome-Based Costs
Cost per Responder
$268
Cost per Remission
$268
Comparison vs Ceftriaxone + Azithromycin
Cost Difference
+$60/year
More expensive
QALY Difference
-0.02 QALYs
Worse outcomes
Dominance
No dominance
Gentamicin + Azithromycin (Dual Therapy for Cephalosporin Allergy) Outcomes
for Gonococcal infection
Efficacy Outcomes
Overall Effectiveness
+95%
Response Rate
+95%
Remission Rate
+95%
Common Side Effects
Injection site pain (Gentamicin)
+5%
Diarrhea (Azithromycin 2g)
+20%
Nausea (Azithromycin 2g)
+12%
Abdominal pain (Azithromycin 2g)
+8%
Ototoxicity (Gentamicin, rare)
+0.1%
Sources:
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Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov