Ceftriaxone + Doxycycline (Dual Therapy)

Treatment for Gonococcal infection

Typical Dosage: Ceftriaxone 500mg IM + Doxycycline 100mg oral BID x 7 days

Effectiveness
97%
Safety Score
70%
Clinical Trials
110
Participants
16K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
Ceftriaxone 500mg IM + Doxycycline 100mg oral BID x 7 days
Time to Effect
1-3 days
Treatment Duration
Ceftriaxone single dose, Doxycycline 7 days
Evidence Quality
HIGH
Number Needed to Treat (NNT)
1.2(Treat 1.2 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
8(Treat 8 patients to see 1 additional serious adverse event)
Confidence Score
92%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$35
Monitoring:$150
Side Effect Mgmt:$30
Total Annual:$215
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
QALYs Gained
0.07
Outcome-Based Costs
Cost per Responder
$222
Cost per Remission
$222
Comparison vs Ceftriaxone + Azithromycin
Cost Difference
+$20/year
More expensive
QALY Difference
0.00 QALYs
Same outcomes
Dominance
No dominance
Ceftriaxone + Doxycycline (Dual Therapy) Outcomes

for Gonococcal infection

Efficacy Outcomes
Overall Effectiveness
+97%
Response Rate
+97%
Remission Rate
+97%
Common Side Effects
Injection site pain (Ceftriaxone)
+10%
Nausea (Doxycycline)
+10%
Photosensitivity (Doxycycline)
+15%
Diarrhea (Doxycycline)
+5%
Esophageal irritation (Doxycycline)
+1%

Sources:

cdc.gov
nih.gov
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov