Condition

Gonococcal infection

Clinical trials and treatment information for Gonococcal infection

39.5M
People Affected
25
Active Trials
82M
New Cases/Year
414
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Ceftriaxone + Azithromycin (Dual Therapy)
98% Effectiveness• 95% Confidence• 70% Safety• 160 trials• 22K participants
HIGH EvidenceExcellent ValueDose: Ceftriaxone 500mg IM + Azithromycin 1g oral
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
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70
DangerousModerateSafe

Time to Effect

1-3 days

Duration

Single dose

Response Rate

98%

Remission Rate

98%

Number Needed to Treat (NNT)

1.1

Number Needed to Harm (NNH)

10

Common Side Effects:

Injection site pain (Ceftriaxone): 10%
Diarrhea (Azithromycin): 14%
Nausea (Azithromycin): 7%
Abdominal pain (Azithromycin): 5%
Rash: 3%

Annual Cost of Care

Drug Cost

$25

Monitoring

$150

Side Effects

$20

Total Annual

$195

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.07

Cost per Remission

$199

Cost per Responder

$199

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+98%
Response Rate
+98%
Remission Rate
+98%
Common Side Effects
Injection site pain (Ceftriaxone)
+10%
Diarrhea (Azithromycin)
+14%
Nausea (Azithromycin)
+7%

Clinical Trial Phases:

Phase 4
2
Ceftriaxone + Doxycycline (Dual Therapy)
97% Effectiveness• 92% Confidence• 70% Safety• 110 trials• 16K participants
HIGH EvidenceExcellent ValueDose: Ceftriaxone 500mg IM + Doxycycline 100mg oral BID x 7 days
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

1-3 days

Duration

Ceftriaxone single dose, Doxycycline 7 days

Response Rate

97%

Remission Rate

97%

Number Needed to Treat (NNT)

1.2

Number Needed to Harm (NNH)

8

Common Side Effects:

Injection site pain (Ceftriaxone): 10%
Nausea (Doxycycline): 10%
Photosensitivity (Doxycycline): 15%
Diarrhea (Doxycycline): 5%
Esophageal irritation (Doxycycline): 1%

Annual Cost of Care

Drug Cost

$35

Monitoring

$150

Side Effects

$30

Total Annual

$215

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.07

Cost per Remission

$222

Cost per Responder

$222

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+97%
Response Rate
+97%
Remission Rate
+97%
Common Side Effects
Injection site pain (Ceftriaxone)
+10%
Nausea (Doxycycline)
+10%
Photosensitivity (Doxycycline)
+15%

Clinical Trial Phases:

Phase 4
3
Gentamicin + Azithromycin (Dual Therapy for Cephalosporin Allergy)
95% Effectiveness• 85% Confidence• 68% Safety• 25 trials• 3.5K participants
MODERATE EvidenceGood ValueDose: Gentamicin 240mg IM + Azithromycin 2g oral
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
68
DangerousModerateSafe

Time to Effect

1-3 days

Duration

Single dose

Response Rate

95%

Remission Rate

95%

Number Needed to Treat (NNT)

1.2

Number Needed to Harm (NNH)

5

Common Side Effects:

Injection site pain (Gentamicin): 5%
Diarrhea (Azithromycin 2g): 20%
Nausea (Azithromycin 2g): 12%
Abdominal pain (Azithromycin 2g): 8%
Ototoxicity (Gentamicin, rare): 0.1%

Annual Cost of Care

Drug Cost

$55

Monitoring

$150

Side Effects

$50

Total Annual

$255

Cost-Effectiveness

GOOD

QALYs Gained

0.05

Cost per Remission

$268

Cost per Responder

$268

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+95%
Response Rate
+95%
Remission Rate
+95%
Common Side Effects
Injection site pain (Gentamicin)
+5%
Diarrhea (Azithromycin 2g)
+20%
Nausea (Azithromycin 2g)
+12%

Clinical Trial Phases:

Phase 4
4
Cefixime + Azithromycin (Dual Therapy, Oral Alternative)
93% Effectiveness• 80% Confidence• 70% Safety• 85 trials• 11K participants
MODERATE EvidenceGood ValueDose: Cefixime 800mg oral + Azithromycin 1g oral
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

1-3 days

Duration

Single dose

Response Rate

93%

Remission Rate

93%

Number Needed to Treat (NNT)

1.3

Number Needed to Harm (NNH)

7

Common Side Effects:

Diarrhea (Cefixime): 18%
Nausea (Cefixime): 7%
Abdominal pain (Cefixime): 5%
Diarrhea (Azithromycin): 14%
Headache: 2%

Annual Cost of Care

Drug Cost

$40

Monitoring

$150

Side Effects

$30

Total Annual

$220

Cost-Effectiveness

GOOD

QALYs Gained

0.04

Cost per Remission

$236

Cost per Responder

$236

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+93%
Response Rate
+93%
Remission Rate
+93%
Common Side Effects
Diarrhea (Cefixime)
+18%
Nausea (Cefixime)
+7%
Abdominal pain (Cefixime)
+5%

Clinical Trial Phases:

Phase 4
5
Gemifloxacin + Azithromycin (Dual Therapy, Oral Alternative)
92% Effectiveness• 75% Confidence• 60% Safety• 18 trials• 2.5K participants
MODERATE EvidenceModerate ValueDose: Gemifloxacin 320mg oral + Azithromycin 2g oral
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe

Time to Effect

1-3 days

Duration

Single dose

Response Rate

92%

Remission Rate

92%

Number Needed to Treat (NNT)

1.4

Number Needed to Harm (NNH)

4

Common Side Effects:

Diarrhea (Azithromycin 2g): 20%
Nausea (Azithromycin 2g): 12%
Rash (Gemifloxacin): 5%
Tendon rupture (Gemifloxacin, rare): 0.05%
Peripheral neuropathy (Gemifloxacin, rare): 0.05%

Annual Cost of Care

Drug Cost

$160

Monitoring

$150

Side Effects

$100

Total Annual

$410

Cost-Effectiveness

MODERATE

QALYs Gained

0.03

Cost per Remission

$446

Cost per Responder

$446

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+92%
Response Rate
+92%
Remission Rate
+92%
Common Side Effects
Diarrhea (Azithromycin 2g)
+20%
Nausea (Azithromycin 2g)
+12%
Rash (Gemifloxacin)
+5%

Clinical Trial Phases:

Phase 4