Nissen Fundoplication (Laparoscopic)
Treatment for GERD
Effectiveness
75%
Safety Score
50%
Clinical Trials
44
Participants
20K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
50
DangerousModerateSafe
Treatment Details
Time to Effect
Weeks for full post-operative recovery
Treatment Duration
One-time procedure, long-term follow-up
Evidence Quality
MODERATENumber Needed to Treat (NNT)
4(Treat 4 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
10(Treat 10 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$0
Monitoring:$200
Side Effect Mgmt:$300
Total Annual:$2,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$30,000/QALY
QALYs Gained
0.25
Outcome-Based Costs
Cost per Responder
$2,857.14
Cost per Remission
$3,636.36
Comparison vs Omeprazole (lifetime therapy)
Cost Difference
+$1,770/year
More expensive
QALY Difference
+0.17 QALYs
Better outcomes
Dominance
No dominance
Nissen Fundoplication (Laparoscopic) Outcomes
for GERD
Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+70%
Remission Rate
+55%
Common Side Effects
Dysphagia (transient)
+20%
Gas-bloat syndrome
+15%
Diarrhea
+10%
Recurrence of GERD
+30%
Surgical complications (bleeding, infection)
+3%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
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Active Clinical Trials
3 active trials recruiting for Nissen Fundoplication (Laparoscopic) in GERD
Development of Machine Learning Models to Predict Postoperative GERD Symptom Resolution After Laparoscopic Nissen Fundoplication
NCT06862037ACTIVE NOT RECRUITING
112 participants
OBSERVATIONAL
Seoul, South Korea
Started: Feb 1, 2017
Multicenter Single-Blind RCT of CTIF Versus LNF For Treatment of GERD in Patients Requiring Hiatal Hernia Repair
NCT04795934ACTIVE NOT RECRUITINGNA
142 participants
INTERVENTIONAL
Irvine, United States +6 more
Started: Jan 26, 2021
LINX vs Fundoplication
NCT07093359RECRUITINGPHASE3
460 participants
INTERVENTIONAL
Oxford, United Kingdom +4 more
Started: Mar 6, 2025
Completed Clinical Trials
14 completed trials for Nissen Fundoplication (Laparoscopic) in GERD
Conventional Nissen Fundoplication Versus Laparoscopic Nissen Fundoplication
NCT01230944COMPLETEDNA
110 participants
INTERVENTIONAL
Turku, Finland
Started: Dec 1, 2004
Comparative Analysis of Postoperative Manometry Outcomes in Nissen vs Toupet Fundoplication
NCT06986902COMPLETEDNA
20 participants
INTERVENTIONAL
Cairo, Egypt
Started: Mar 10, 2024
Intraoperative Endomanometric Laparoscopic Nissen Fundoplication Improves Postoperative Outcomes
NCT05851794COMPLETEDNA
360 participants
INTERVENTIONAL
Started: Apr 1, 2012
A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors
NCT01265550COMPLETEDPHASE3
366 participants
INTERVENTIONAL
Birmingham, United States +14 more
Started: Aug 13, 2012
A Randomized Controlled Trial of Laparoscopic Nissen Fundoplication Treatment of Patients With Chronic GERD
NCT00182260COMPLETEDNA
216 participants
INTERVENTIONAL
Hamilton, Canada
Started: Jan 1, 2000
One Anastomosis Gastric Bypass With Excluded Stomach Fundoplication: FundoRing vs Nissen vs OAGB Without Fundoplication
NCT04828733COMPLETEDNA
150 participants
INTERVENTIONAL
Astana, Kazakhstan
Started: Mar 29, 2019
Clinical Trial Comparing Open and Laparoscopic Nissen Fundoplication in Children
NCT00382850COMPLETEDNA
68 participants
INTERVENTIONAL
Baltimore, United States
Started: Nov 1, 2005
Nissen and Gastroplasty in Gastroesophageal Reflux Disease (GERD)
NCT00872755COMPLETEDPHASE4
90 participants
INTERVENTIONAL
Ioannina, Greece
Started: Jan 1, 2002
A Study on the Effectiveness of Laparoscopic Fundoplication on Extraesophageal Manifestations of Gastroesophageal Reflux Disease (GERD)
NCT01324986COMPLETEDNA
INTERVENTIONAL
Zell am See, Austria
Comparison of Total and Partial Fundoplication During Surgery of Patients With Gastroesophageal Reflux Disease
NCT03659487COMPLETEDNA
460 participants
INTERVENTIONAL
Started: Nov 1, 2001
Laparoscopy in Children: Does it Decrease the Metabolic, Endocrine and Inflammatory Stress Response to Surgery
NCT00231543COMPLETEDNA
INTERVENTIONAL
London, United Kingdom
Minimally Invasive Collis-Nissen for the Treatment of Short Esophagus
NCT02288988COMPLETEDNA
65 participants
INTERVENTIONAL
Bologna, Italy
Started: Jan 1, 1995
Treatment of IPF With Laparoscopic Anti-Reflux Surgery
NCT01982968COMPLETEDNA
58 participants
INTERVENTIONAL
San Francisco, United States +4 more
Started: Dec 1, 2013
Comparison of Laparoscopic Nissen Versus Thal Fundoplication in Children
NCT01027975COMPLETEDNA
INTERVENTIONAL
Oxford (Headington), United Kingdom
Started: Jul 1, 1998
Showing 20 of 48 total trials