Famotidine (H2 Receptor Blocker)
Treatment for GERD
Typical Dosage: 20-40 mg once or twice daily
Effectiveness
60%
Safety Score
82%
Clinical Trials
1
Participants
50K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
82
DangerousModerateSafe
Treatment Details
Dosage Range
20-40 mg once or twice daily
Time to Effect
Within 1 hour
Treatment Duration
6-12 weeks for acute, often indefinite for maintenance
Evidence Quality
HIGHNumber Needed to Treat (NNT)
6(Treat 6 patients to see 1 additional successful outcome)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$20
Monitoring:$150
Side Effect Mgmt:$30
Total Annual:$200
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTICER
$5,000/QALY
QALYs Gained
0.05
Outcome-Based Costs
Cost per Responder
$363.64
Cost per Remission
$571.43
Comparison vs Omeprazole
Cost Difference
$-30/year
Less expensive
QALY Difference
-0.03 QALYs
Worse outcomes
Dominance
No dominance
Famotidine (H2 Receptor Blocker) Outcomes
for GERD
Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+55%
Remission Rate
+35%
Common Side Effects
Headache
+5%
Dizziness
+2%
Constipation
+2%
Diarrhea
+2%
Tachyphylaxis (reduced effectiveness over time)
+15%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
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Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov
Completed Clinical Trials
1 completed trial for Famotidine (H2 Receptor Blocker) in GERD
Verification Study on Lafutidine in Mild Reflux Oesophagitis - Double Blind Controlled Study With Famotidine -
NCT00229424COMPLETEDPHASE3
325 participants
INTERVENTIONAL
1-1, Seiryo-cho, Aoba-ku, Sendai, Miyagi, Japan
Started: Apr 1, 2005