Condition

Frontotemporal Dementia

Clinical trials and treatment information for Frontotemporal Dementia, which affects the frontal and temporal lobes.

2.8M
People Affected
80
Active Trials
85K
New Cases/Year
98K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Olanzapine
70% Effectiveness• 55% Confidence• 40% Safety• 15 trials• 800 participants
MODERATE EvidencePoor ValueDose: 2.5-10mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
40
DangerousModerateSafe

Time to Effect

Days to weeks

Duration

Short-term or lowest effective dose, long-term monitoring

Response Rate

60%

Remission Rate

%

Number Needed to Treat (NNT)

6

Number Needed to Harm (NNH)

20

Common Side Effects:

Sedation: 30%
Weight gain: 20%
Metabolic changes: 15%
Extrapyramidal symptoms: 10%
Increased risk of stroke/TIA: 2%

Annual Cost of Care

Drug Cost

$75

Monitoring

$250

Side Effects

$750

Total Annual

$1,075

Cost-Effectiveness

POOR

QALYs Gained

0.05

Cost per Responder

$1,791.67

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+60%
Common Side Effects
Sedation
+30%
Weight gain
+20%
Metabolic changes
+15%

Clinical Trial Phases:

Phase 4
2
Sertraline
60% Effectiveness• 65% Confidence• 62% Safety• 20 trials• 600 participants
MODERATE EvidenceExcellent ValueDose: 50-200mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
62
DangerousModerateSafe

Time to Effect

4-6 weeks

Duration

Lifetime

Response Rate

50%

Remission Rate

%

Number Needed to Treat (NNT)

10

Common Side Effects:

Nausea: 25%
Diarrhea: 15%
Insomnia: 15%
Headache: 12%
Sexual dysfunction: 18%

Annual Cost of Care

Drug Cost

$30

Monitoring

$75

Side Effects

$20

Total Annual

$125

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.08

Cost per Responder

$250

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+60%
Response Rate
+50%
Common Side Effects
Nausea
+25%
Diarrhea
+15%
Insomnia
+15%

Clinical Trial Phases:

Phase 4
3
Paroxetine
58% Effectiveness• 60% Confidence• 58% Safety• 15 trials• 400 participants
MODERATE EvidenceExcellent ValueDose: 20-50mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
58
DangerousModerateSafe

Time to Effect

4-6 weeks

Duration

Lifetime

Response Rate

48%

Remission Rate

%

Number Needed to Treat (NNT)

11

Common Side Effects:

Nausea: 28%
Somnolence: 20%
Sexual dysfunction: 22%
Dry mouth: 15%
Constipation: 10%

Annual Cost of Care

Drug Cost

$40

Monitoring

$75

Side Effects

$20

Total Annual

$135

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.07

Cost per Responder

$281.25

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+58%
Response Rate
+48%
Common Side Effects
Nausea
+28%
Somnolence
+20%
Sexual dysfunction
+22%

Clinical Trial Phases:

Phase 4
4
Citalopram
55% Effectiveness• 60% Confidence• 58% Safety• 1 trials• 500 participants
MODERATE EvidenceExcellent ValueDose: 10-40mg daily (max 20mg in elderly)
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
58
DangerousModerateSafe

Time to Effect

4-6 weeks

Duration

Lifetime

Response Rate

45%

Remission Rate

%

Number Needed to Treat (NNT)

12

Common Side Effects:

Nausea: 25%
Insomnia/Somnolence: 15%
Dry mouth: 12%
Sexual dysfunction: 18%
QTc prolongation: 1%

Annual Cost of Care

Drug Cost

$35

Monitoring

$75

Side Effects

$20

Total Annual

$130

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.07

Cost per Responder

$288.89

Treatment Outcomes
Primary Outcomes
Agitation/Aggression (NPI-Agitation/Aggression subscale)NPI-Agitation/Aggression score: 9/12
-25% (-2.25 points)
Disinhibition (NPI-Disinhibition subscale)NPI-Disinhibition score: 7/12
-20% (-1.4 points)
Apathy (NPI-Apathy subscale)NPI-Apathy score: 8/12
+12.5% (+1.0 points)
Caregiver Distress (NPI-Caregiver Distress total)NPI-Caregiver Distress total: 30/60
-15% (-4.5 points)
Secondary Benefits
Overall Neuropsychiatric Symptom Severity (NPI Total Score)NPI Total Score: 40/144
-8% (-3.2 points)
Cognitive Function (ACE-III Total Score)ACE-III score: 70/100
-4% (-2.8 points)
Depression Severity (CSDD Score)CSDD score: 12/38
-25% (-3.0 points)
Common Side Effects
Nausea
+25%
Insomnia/Somnolence
+15%
Dry mouth
+12%

Clinical Trial Phases:

Phase 4
5
Trazodone
50% Effectiveness• 60% Confidence• 55% Safety• 10 trials• 300 participants
LOW-MODERATE EvidenceExcellent ValueDose: 50-300mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
55
DangerousModerateSafe

Time to Effect

Hours for sedation, days to weeks for agitation

Duration

Lifetime

Response Rate

50%

Remission Rate

%

Number Needed to Treat (NNT)

8

Common Side Effects:

Drowsiness: 35%
Dizziness: 18%
Orthostatic hypotension: 10%
Dry mouth: 15%
Priapism (rare): 0.1%

Annual Cost of Care

Drug Cost

$30

Monitoring

$75

Side Effects

$20

Total Annual

$125

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.06

Cost per Responder

$250

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+50%
Response Rate
+50%
Common Side Effects
Drowsiness
+35%
Dizziness
+18%
Orthostatic hypotension
+10%

Clinical Trial Phases:

Phase 4