Clofazimine (as part of regimens)

Treatment for Extensively drug-resistant tuberculosis

Typical Dosage: 100-200mg daily

Effectiveness
65%
Safety Score
60%
Clinical Trials
15
Participants
1K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
100-200mg daily
Time to Effect
3-6 months
Treatment Duration
6-18 months
Evidence Quality
LOW
Confidence Score
75%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$400
Monitoring:$750
Side Effect Mgmt:$300
Total Annual:$1,450
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
GOOD
ICER
$40,000/QALY
QALYs Gained
0.6
Outcome-Based Costs
Cost per Responder
$2,231
Cost per Remission
$2,231
Comparison vs Less effective older XDR-TB regimens
Cost Difference
$-1,000/year
Less expensive
QALY Difference
+0.30 QALYs
Better outcomes
Dominance
No dominance
Clofazimine (as part of regimens) Outcomes

for Extensively drug-resistant tuberculosis

Efficacy Outcomes
Overall Effectiveness
+65%
Response Rate
+65%
Remission Rate
+65%
Common Side Effects
Skin discoloration (reddish-brown to black)
+90%
Gastrointestinal intolerance
+45%
Ichthyosis/dry skin
+15%

Sources:

nih.gov
escholarship.org
nih.gov

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov