Methotrexate (Systemic)

Treatment for Ectopic pregnancy

Typical Dosage: 50 mg/m^2 IM (single-dose) or 1 mg/kg IM alternating with folinic acid (multi-dose)

Effectiveness
90%
Safety Score
30%
Clinical Trials
2
Participants
12K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
30
DangerousModerateSafe
Treatment Details
Dosage Range
50 mg/m^2 IM (single-dose) or 1 mg/kg IM alternating with folinic acid (multi-dose)
Time to Effect
2-4 weeks for hCG resolution
Treatment Duration
single dose or multi-dose over 8 days, monitoring for 2-4 weeks
Evidence Quality
HIGH
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$200
Monitoring:$1,000
Side Effect Mgmt:$300
Total Annual:$1,500
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
QALYs Gained
0.9
Outcome-Based Costs
Cost per Responder
$1,667
Cost per Remission
$1,667
Comparison vs Laparoscopic Salpingectomy
Cost Difference
$-7,000/year
Less expensive
QALY Difference
+0.05 QALYs
Better outcomes
Dominance
DOMINATESBetter + cheaper
Methotrexate (Systemic) Outcomes

for Ectopic pregnancy

Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+90%
Remission Rate
+90%
Common Side Effects
Abdominal pain/cramping
+50%
Nausea/vomiting
+15%
Fatigue
+15%
Transient liver enzyme elevation
+10%
Stomatitis
+3%

Sources:

medicalsciencejournal.com
nih.gov
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

You can search for trials, but you probably can't join any because the 1% Treaty hasn't passed yet. Most trials are severely limited by lack of funding and bureaucratic barriers. Help change this!

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Active Clinical Trials
1 active trial recruiting for Methotrexate (Systemic) in Ectopic pregnancy

Local vs Systemic Methotrexate in Management of Uterine Ectopic Pregnancy

NCT06554470RECRUITINGNA
View Study
34 participants
INTERVENTIONAL
Tanta, Egypt
Started: Aug 15, 2024
Completed Clinical Trials
1 completed trial for Methotrexate (Systemic) in Ectopic pregnancy

The Impact of Salpingectomy and Single Dose Systemic Methotrexate Treatments on Ovarian Reserve in Ectopic Pregnancy

NCT02714998COMPLETEDNA
View Study
131 participants
INTERVENTIONAL
Izmir, Turkey (Türkiye)
Started: Jan 1, 2013