Condition

Ectopic pregnancy

Clinical trials and treatment information for Ectopic pregnancy

69K
People Affected
5
Active Trials
2M
New Cases/Year
6,442
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Laparoscopic Salpingectomy
100% Effectiveness• 95% Confidence• 50% Safety• 8 trials• 20K participants
HIGH EvidenceModerate ValueDose: surgical procedure
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
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50
DangerousModerateSafe

Time to Effect

immediate

Duration

single procedure, 1-2 weeks recovery

Response Rate

100%

Remission Rate

100%

Common Side Effects:

Post-operative pain: 80%
Nausea/vomiting (anesthesia-related): 25%
Infection (wound/pelvic): 3%
Bleeding/hematoma: 2%
Injury to other organs: 0.5%

Annual Cost of Care

Drug Cost

$350

Monitoring

$450

Side Effects

$1,000

Total Annual

$8,000

Cost-Effectiveness

MODERATE

QALYs Gained

0.8

Cost per Remission

$8,000

Cost per Responder

$8,000

Treatment Outcomes
Primary Outcomes
Serum beta-hCG levels3000 mIU/mL
-98% (-2940 mIU/mL)
Abdominal Pain Score (VAS 0-10)7/10
-80% (-5.6 points)
Intra-abdominal Free Fluid (ultrasound-estimated)150 cm3
-100% (-150 cm3)
Secondary Benefits
Time to Return to Normal Activities4 weeks
-50% (-2 weeks)
Anxiety Score (GAD-7)14/21
-60% (-8.4 points)
Overall Hospital Stay Duration3 days
-66.7% (-2 days)
Common Side Effects
Post-operative pain
+80%
Nausea/vomiting (anesthesia-related)
+25%
Infection (wound/pelvic)
+3%

Clinical Trial Phases:

Phase 4
2
Methotrexate (Systemic)
90% Effectiveness• 90% Confidence• 30% Safety• 2 trials• 12K participants
HIGH EvidenceExcellent ValueDose: 50 mg/m^2 IM (single-dose) or 1 mg/kg IM alternating with folinic acid (multi-dose)
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
30
DangerousModerateSafe

Time to Effect

2-4 weeks for hCG resolution

Duration

single dose or multi-dose over 8 days, monitoring for 2-4 weeks

Response Rate

90%

Remission Rate

90%

Common Side Effects:

Abdominal pain/cramping: 50%
Nausea/vomiting: 15%
Fatigue: 15%
Transient liver enzyme elevation: 10%
Stomatitis: 3%

Annual Cost of Care

Drug Cost

$200

Monitoring

$1,000

Side Effects

$300

Total Annual

$1,500

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.9

Cost per Remission

$1,667

Cost per Responder

$1,667

Treatment Outcomes
Primary Outcomes
Serum Beta-hCG levels2000 mIU/mL
-99.75% (-1995 mIU/mL)
Ectopic mass diameter2.5 cm
-100% (-2.5 cm)
Ectopic Pregnancy Resolution Rate (Medical Management)Resolution rate at treatment initiation: 0%
+85% (+85% absolute increase in resolution rate)
Secondary Benefits
Fallopian Tube Preservation RateRate of tube preservation with salpingectomy: 0%
+85% (+85% absolute increase in tube preservation)
Subsequent Intrauterine Pregnancy RateExpected IUP rate after surgical treatment (salpingostomy): 65%
+7.7% (+5% absolute increase (e.g., from 65% to 70%))
Blood Transfusion RateRisk of transfusion with surgical management for ectopic pregnancy: 5%
-100% (-5% absolute reduction in transfusion rate)
Common Side Effects
Abdominal pain/cramping
+50%
Nausea/vomiting
+15%
Fatigue
+15%

Clinical Trial Phases:

Phase 4
3
Laparoscopic Salpingostomy
85% Effectiveness• 90% Confidence• 50% Safety• 5 trials• 15K participants
HIGH EvidenceModerate ValueDose: surgical procedure
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
50
DangerousModerateSafe

Time to Effect

immediate removal, 2-4 weeks for hCG resolution with monitoring

Duration

single procedure, monitoring for 2-4 weeks

Response Rate

85%

Remission Rate

85%

Common Side Effects:

Post-operative pain: 80%
Nausea/vomiting (anesthesia-related): 25%
Persistent trophoblast (requiring further treatment): 15%
Infection (wound/pelvic): 3%
Bleeding/hematoma: 2%

Annual Cost of Care

Drug Cost

$350

Monitoring

$750

Side Effects

$1,500

Total Annual

$9,000

Cost-Effectiveness

MODERATE

QALYs Gained

0.85

Cost per Remission

$10,588

Cost per Responder

$10,588

Treatment Outcomes
Primary Outcomes
Serum Human Chorionic Gonadotropin (hCG)2500 mIU/mL
-99% (-2475 mIU/mL)
Ectopic Mass Size2.5 cm (mean diameter)
-100% (-2.5 cm)
Abdominal Pain IntensityVAS Pain Score: 7/10
-85% (-6 points on VAS)
Persistence of Ectopic Pregnancy (requiring further intervention)100% of patients with ectopic pregnancy
-92% (-92 percentage points (reduction in patients with persistent disease))
Secondary Benefits
Subsequent Intrauterine Pregnancy Rate (within 2 years)40% (typical rate after salpingectomy or untreated)
+50% (+20 percentage points)
Hospital Stay Duration3 days
-66.7% (-2 days)
Health-Related Quality of Life (Physical Component)SF-36 PCS score: 40/100
+15% (+6 points on SF-36 PCS)
Common Side Effects
Post-operative pain
+80%
Nausea/vomiting (anesthesia-related)
+25%
Persistent trophoblast (requiring further treatment)
+15%

Clinical Trial Phases:

Phase 4
4
Expectant Management
65% Effectiveness• 75% Confidence• 70% Safety• 8 trials• 6K participants
MODERATE EvidenceGood Value
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe

Time to Effect

weeks to months for spontaneous resolution

Duration

weeks to months of close monitoring

Response Rate

65%

Remission Rate

65%

Common Side Effects:

Anxiety/stress: 70%
Prolonged monitoring: 100%
Need for subsequent intervention (MTX or surgery): 35%
Tubal rupture (life-threatening): 7%

Annual Cost of Care

Drug Cost

$0

Monitoring

$1,500

Side Effects

$2,550

Total Annual

$4,050

Cost-Effectiveness

GOOD

QALYs Gained

0.7

Cost per Remission

$6,230

Cost per Responder

$6,230

Treatment Outcomes
Primary Outcomes
Serum Beta-hCG Levels1800 mIU/mL
-99% (-1795 mIU/mL (to <5 mIU/mL))
Ectopic Mass Diameter (on ultrasound)2.8 cm
-100% (-2.8 cm (to absence))
Pelvic Pain Score (VAS 0-10)4/10
-100% (-4 points (to 0/10))
Secondary Benefits
Anxiety Score (GAD-7 0-21)10/21
-50% (-5 points)
Quality of Life (EQ-5D-5L Index Score)0.78
+10% (+0.078 points)
Hemoglobin Concentration12.8 g/dL
+0.8% (+0.1 g/dL)
Common Side Effects
Anxiety/stress
+70%
Prolonged monitoring
+100%
Need for subsequent intervention (MTX or surgery)
+35%

Clinical Trial Phases:

Phase 4