Isoniazid (INH) Monotherapy (9 months for Latent TB Infection)

Treatment for Drug-susceptible tuberculosis

Typical Dosage: Isoniazid 300mg daily

Effectiveness
75%
Safety Score
65%
Clinical Trials
300
Participants
100K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe
Treatment Details
Dosage Range
Isoniazid 300mg daily
Time to Effect
Prevention initiated within weeks, protective effect over years
Treatment Duration
9 months
Evidence Quality
HIGH
Number Needed to Treat (NNT)
15(Treat 15 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
200(Treat 200 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$75
Monitoring:$200
Side Effect Mgmt:$50
Total Annual:$325
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
ICER
$30,000/QALY
QALYs Gained
0.1
Isoniazid (INH) Monotherapy (9 months for Latent TB Infection) Outcomes

for Drug-susceptible tuberculosis

Efficacy Outcomes
Overall Effectiveness
+75%
Common Side Effects
Hepatotoxicity (clinical hepatitis)
+10%
Peripheral neuropathy
+20%
GI upset
+5%
Rash
+3%

Sources:

nih.gov
nih.gov
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov