3HP Regimen (Isoniazid + Rifapentine weekly for 3 months for Latent TB Infection)

Treatment for Drug-susceptible tuberculosis

Typical Dosage: Isoniazid 900mg weekly, Rifapentine 900mg weekly

Effectiveness
78%
Safety Score
60%
Clinical Trials
15
Participants
10K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe
Treatment Details
Dosage Range
Isoniazid 900mg weekly, Rifapentine 900mg weekly
Time to Effect
Prevention initiated within weeks, protective effect over years
Treatment Duration
3 months (weekly)
Evidence Quality
HIGH
Number Needed to Treat (NNT)
12(Treat 12 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
35(Treat 35 patients to see 1 additional serious adverse event)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$1,300
Monitoring:$150
Side Effect Mgmt:$75
Total Annual:$1,525
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENT
ICER
$15,000/QALY
QALYs Gained
0.12
Comparison vs Isoniazid (INH) Monotherapy (9 months)
Cost Difference
+$1,200/year
More expensive
QALY Difference
+0.02 QALYs
Better outcomes
Dominance
No dominance
3HP Regimen (Isoniazid + Rifapentine weekly for 3 months for Latent TB Infection) Outcomes

for Drug-susceptible tuberculosis

Efficacy Outcomes
Overall Effectiveness
+78%
Common Side Effects
Flu-like syndrome
+10%
Rash
+10%
Hepatotoxicity
+5%
GI upset
+8%

Sources:

nih.gov
nih.gov
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov