Condition

Drug-susceptible tuberculosis

Clinical trials and treatment information for Drug-susceptible tuberculosis

13.8M
People Affected
300
Active Trials
10.5M
New Cases/Year
1M
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Standard 6-Month Regimen (Isoniazid, Rifampicin, Pyrazinamide, Ethambutol then Isoniazid, Rifampicin for active TB)
95% Effectiveness• 98% Confidence• 58% Safety• 500 trials• 200K participants
HIGH EvidenceExcellent ValueDose: Isoniazid 300mg daily, Rifampicin 600mg daily, Pyrazinamide 1500-2000mg daily, Ethambutol 800-1200mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
58
DangerousModerateSafe

Time to Effect

2-4 weeks for clinical improvement, 2 months for sputum conversion

Duration

6 months

Response Rate

95%

Remission Rate

92%

Number Needed to Harm (NNH)

35

Common Side Effects:

Hepatotoxicity (elevated LFTs, clinical hepatitis): 20%
Peripheral neuropathy: 20%
GI upset (nausea, vomiting, abdominal pain): 15%
Arthralgia: 20%
Optic neuritis: 5%
Orange/red discoloration of body fluids: 100%

Annual Cost of Care

Drug Cost

$400

Monitoring

$1,500

Side Effects

$300

Total Annual

$2,200

Cost-Effectiveness

EXCELLENT

QALYs Gained

1.5

ICER

$15,000/QALY

Cost per Remission

$2,391

Cost per Responder

$2,316

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+95%
Response Rate
+95%
Remission Rate
+92%
Common Side Effects
Hepatotoxicity (elevated LFTs, clinical hepatitis)
+20%
Peripheral neuropathy
+20%
GI upset (nausea, vomiting, abdominal pain)
+15%

Clinical Trial Phases:

Phase 3Phase 4
2
Shorter 4-Month Regimen (High-dose Rifapentine, Isoniazid, Pyrazinamide, Moxifloxacin then High-dose Rifapentine, Isoniazid, Moxifloxacin for active TB)
94% Effectiveness• 95% Confidence• 55% Safety• 15 trials• 8K participants
HIGH EvidenceExcellent ValueDose: Rifapentine 1200mg daily, Isoniazid 300mg daily, Pyrazinamide 1000-1500mg daily, Moxifloxacin 400mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
55
DangerousModerateSafe

Time to Effect

2-4 weeks for clinical improvement, 2 months for sputum conversion

Duration

4 months

Response Rate

94%

Remission Rate

90%

Number Needed to Harm (NNH)

20

Common Side Effects:

Hepatotoxicity (Grade 1-4): 15%
GI upset (nausea, vomiting, diarrhea): 25%
Peripheral neuropathy: 15%
Rash: 10%
Arthralgia: 20%
QT prolongation: 3%
Tendinopathy: 1%

Annual Cost of Care

Drug Cost

$2,300

Monitoring

$1,000

Side Effects

$450

Total Annual

$3,750

Cost-Effectiveness

EXCELLENT

QALYs Gained

1.5

ICER

$12,000/QALY

Cost per Remission

$4,167

Cost per Responder

$3,989

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+94%
Response Rate
+94%
Remission Rate
+90%
Common Side Effects
Hepatotoxicity (Grade 1-4)
+15%
GI upset (nausea, vomiting, diarrhea)
+25%
Peripheral neuropathy
+15%

Clinical Trial Phases:

Phase 3Phase 4
3
3HP Regimen (Isoniazid + Rifapentine weekly for 3 months for Latent TB Infection)
78% Effectiveness• 90% Confidence• 60% Safety• 15 trials• 10K participants
HIGH EvidenceExcellent ValueDose: Isoniazid 900mg weekly, Rifapentine 900mg weekly
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
60
DangerousModerateSafe

Time to Effect

Prevention initiated within weeks, protective effect over years

Duration

3 months (weekly)

Response Rate

%

Remission Rate

%

Number Needed to Treat (NNT)

12

Number Needed to Harm (NNH)

35

Common Side Effects:

Flu-like syndrome: 10%
Rash: 10%
Hepatotoxicity: 5%
GI upset: 8%

Annual Cost of Care

Drug Cost

$1,300

Monitoring

$150

Side Effects

$75

Total Annual

$1,525

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.12

ICER

$15,000/QALY

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+78%
Common Side Effects
Flu-like syndrome
+10%
Rash
+10%
Hepatotoxicity
+5%

Clinical Trial Phases:

Phase 3Phase 4
4
Rifampicin (RIF) Monotherapy (4 months for Latent TB Infection)
77% Effectiveness• 90% Confidence• 68% Safety• 25 trials• 20K participants
HIGH EvidenceExcellent ValueDose: Rifampicin 600mg daily
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
68
DangerousModerateSafe

Time to Effect

Prevention initiated within weeks, protective effect over years

Duration

4 months

Response Rate

%

Remission Rate

%

Number Needed to Treat (NNT)

15

Number Needed to Harm (NNH)

150

Common Side Effects:

GI upset: 10%
Orange/red discoloration of body fluids: 100%
Hepatotoxicity: 3%
Rash: 5%

Annual Cost of Care

Drug Cost

$120

Monitoring

$150

Side Effects

$50

Total Annual

$320

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.1

ICER

$25,000/QALY

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+77%
Common Side Effects
GI upset
+10%
Orange/red discoloration of body fluids
+100%
Hepatotoxicity
+3%

Clinical Trial Phases:

Phase 3Phase 4
5
Isoniazid (INH) Monotherapy (9 months for Latent TB Infection)
75% Effectiveness• 95% Confidence• 65% Safety• 300 trials• 100K participants
HIGH EvidenceExcellent ValueDose: Isoniazid 300mg daily
Find Trials

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe

Time to Effect

Prevention initiated within weeks, protective effect over years

Duration

9 months

Response Rate

%

Remission Rate

%

Number Needed to Treat (NNT)

15

Number Needed to Harm (NNH)

200

Common Side Effects:

Hepatotoxicity (clinical hepatitis): 10%
Peripheral neuropathy: 20%
GI upset: 5%
Rash: 3%

Annual Cost of Care

Drug Cost

$75

Monitoring

$200

Side Effects

$50

Total Annual

$325

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.1

ICER

$30,000/QALY

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+75%
Common Side Effects
Hepatotoxicity (clinical hepatitis)
+10%
Peripheral neuropathy
+20%
GI upset
+5%

Clinical Trial Phases:

Phase 3Phase 4