Thyroid Hormone Replacement (Levothyroxine) for Hypothyroidism
Treatment for Down syndrome
Typical Dosage: 2-6 mcg/kg/day, titrated to TSH levels
Effectiveness
95%
Safety Score
65%
Clinical Trials
100
Participants
10K
Comparative Safety Scale(Higher is safer)
Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe
Treatment Details
Dosage Range
2-6 mcg/kg/day, titrated to TSH levels
Time to Effect
2-4 weeks
Treatment Duration
lifetime
Evidence Quality
HIGHNumber Needed to Treat (NNT)
3(Treat 3 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
10(Treat 10 patients to see 1 additional serious adverse event)
Confidence Score
95%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$100
Monitoring:$200
Side Effect Mgmt:$50
Total Annual:$350
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
EXCELLENTQALYs Gained
1.5
Outcome-Based Costs
Cost per Responder
$368.42
Thyroid Hormone Replacement (Levothyroxine) for Hypothyroidism Outcomes
for Down syndrome
Efficacy Outcomes
Overall Effectiveness
+95%
Response Rate
+95%
Common Side Effects
Hyperactivity (from overdose)
+5%
Insomnia (from overdose)
+3%
Tremors (from overdose)
+2%
Sources:
WARNING: LIMITED TRIALS AVAILABLE
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Active Clinical Trials
No active trials currently recruiting for this treatment
No active trials found in ClinicalTrials.gov