Rifaximin (with fiber supplement)

Treatment for Diverticulitis

Typical Dosage: 400mg BID or TID (cyclical)

Effectiveness
40%
Safety Score
70%
Clinical Trials
30
Participants
5K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
70
DangerousModerateSafe
Treatment Details
Dosage Range
400mg BID or TID (cyclical)
Time to Effect
Weeks to months
Treatment Duration
Intermittent cycles (e.g., 7-10 days/month) or continuous
Evidence Quality
MODERATE
Number Needed to Treat (NNT)
25(Treat 25 patients to see 1 additional successful outcome)
Number Needed to Harm (NNH)
50(Treat 50 patients to see 1 additional serious adverse event)
Confidence Score
60%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$8,000
Monitoring:$200
Side Effect Mgmt:$50
Total Annual:$8,250
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
POOR
QALYs Gained
0.02
Outcome-Based Costs
Cost per Responder
$27,500
Comparison vs High-Fiber Diet
Cost Difference
+$8,200/year
More expensive
QALY Difference
-0.18 QALYs
Worse outcomes
Dominance
No dominance
Prescription Access Economics
Annual Societal Loss per Patient
$6,450
Cost of prescription-only barriers (visits, time, admin, price premium)
Physician Visit Cost
$300/year
Time Cost
$100/year
Travel + wait time
Insurance Admin Cost
$50/year
Prior auth, claims
Rx Price
$8,000/year
Potential OTC Price
$2,000/year
Estimated if OTC available
Early Treatment Benefit
+0.00 QALYs
From faster OTC access
Risk Assessment
Misuse Risk
MODERATE
Missed Diagnosis Risk
LOW
Rifaximin (with fiber supplement) Outcomes

for Diverticulitis

Efficacy Outcomes
Overall Effectiveness
+40%
Response Rate
+30%
Common Side Effects
Nausea
+7%
Abdominal pain
+5%
Peripheral edema
+6%
Dizziness
+3%

Sources:

nih.gov
nih.gov
frontiersin.org

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov