Condition

Dengue

Clinical trials and treatment information for Dengue

3.5M
People Affected
50
Active Trials
100M
New Cases/Year
29K
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Intravenous Fluid Therapy (Crystalloids)
95% Effectiveness• 90% Confidence• 65% Safety• 50 trials• 20K participants
HIGH EvidenceExcellent ValueDose: Initial 10-20 mL/kg bolus over 15-30 min, then maintenance 3-5 mL/kg/hr, guided by hemodynamics
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
65
DangerousModerateSafe

Time to Effect

Immediate

Duration

12-72 hours

Response Rate

90%

Remission Rate

%

Number Needed to Treat (NNT)

5

Number Needed to Harm (NNH)

20

Common Side Effects:

Fluid overload (pulmonary edema): 8%
Electrolyte imbalance: 5%
Catheter-related infection: 1%

Annual Cost of Care

Drug Cost

$150

Monitoring

$8,000

Side Effects

$500

Total Annual

$8,650

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.8

Cost per Responder

$9,611.11

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+95%
Response Rate
+90%
Common Side Effects
Fluid overload (pulmonary edema)
+8%
Electrolyte imbalance
+5%
Catheter-related infection
+1%

Clinical Trial Phases:

Phase 4
2
Clinical Monitoring and Early Intervention
92% Effectiveness• 90% Confidence• 95% Safety• 100 trials• 50K participants
HIGH EvidenceExcellent ValueDose: Daily clinical assessment including vital signs, fluid intake/output, hematocrit, platelet count
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
95
DangerousModerateSafe

Time to Effect

Ongoing throughout critical phase (3-7 days after symptom onset)

Duration

3-7 days

Response Rate

90%

Remission Rate

%

Number Needed to Treat (NNT)

10

Common Side Effects:

Patient anxiety: 2%

Annual Cost of Care

Drug Cost

$0

Monitoring

$500

Side Effects

$0

Total Annual

$500

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.7

Cost per Responder

$555.56

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+92%
Response Rate
+90%
Common Side Effects
Patient anxiety
+2%

Clinical Trial Phases:

Phase 4
3
Oral Rehydration Therapy
90% Effectiveness• 95% Confidence• 95% Safety• 1 trials• 500K participants
HIGH EvidenceExcellent ValueDose: As tolerated, 50-100 mL/kg/day for adults, frequent small sips
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
95
DangerousModerateSafe

Time to Effect

Hours

Duration

3-7 days

Response Rate

95%

Remission Rate

%

Common Side Effects:

Vomiting: 5%
Transient electrolyte imbalance: 1%

Annual Cost of Care

Drug Cost

$10

Monitoring

$20

Side Effects

$0

Total Annual

$30

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.2

Cost per Responder

$31.58

Treatment Outcomes
Primary Outcomes
Dehydration Severity ScoreClinical Assessment Score: 6/10
-60% (-3.6 points)
Hematocrit (HCT)48%
-8% (-3.8 percentage points)
Urine Output0.5 mL/kg/hr
+100% (+0.5 mL/kg/hr)
Mean Arterial Pressure (MAP)68 mmHg
+10% (+6.8 mmHg)
Secondary Benefits
Need for Intravenous (IV) Fluid Therapy40% of patients
-50% (-20 percentage points)
Frequency of Vomiting Episodes4 episodes/24 hours
-25% (-1 episode/24 hours)
Self-reported Fatigue ScoreVAS Scale: 7/10
-20% (-1.4 points)
Common Side Effects
Vomiting
+5%
Transient electrolyte imbalance
+1%

Clinical Trial Phases:

Phase 4
4
Acetaminophen (Paracetamol)
85% Effectiveness• 95% Confidence• 80% Safety• 1 trials• 1M participants
HIGH EvidenceExcellent ValueDose: 500-1000mg every 4-6 hours, max 4g/day
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
80
DangerousModerateSafe

Time to Effect

30-60 minutes

Duration

3-7 days, as needed

Response Rate

90%

Remission Rate

%

Number Needed to Treat (NNT)

2

Number Needed to Harm (NNH)

100000

Common Side Effects:

Gastrointestinal upset: 2%
Allergic skin reactions: 0.5%
Liver enzyme elevation (reversible): 0.1%
Acute liver failure (overdose): 0.001%

Annual Cost of Care

Drug Cost

$5

Monitoring

$600

Side Effects

$0

Total Annual

$605

Cost-Effectiveness

EXCELLENT

QALYs Gained

0.02

Cost per Responder

$5.56

Treatment Outcomes
Primary Outcomes
Body Temperature39.5 °C
-3.8% (-1.5 °C)
Pain Intensity (Numeric Rating Scale)NRS score: 7/10
-40% (-2.8 points)
Myalgia Severity (Numeric Rating Scale)NRS score: 6/10
-35% (-2.1 points)
Headache Severity (Numeric Rating Scale)NRS score: 6/10
-35% (-2.1 points)
Secondary Benefits
Time to Sustained DefervescenceMean 72 hours
-33.3% (-24 hours)
Overall Dengue Symptom Score (e.g., DSS-10)Score: 18/30
-30% (-5.4 points)
Daily Activity Limitation Score (e.g., ADL Scale)Score: 4/5
-30% (-1.2 points)
Common Side Effects
Gastrointestinal upset
+2%
Allergic skin reactions
+0.5%
Liver enzyme elevation (reversible)
+0.1%

Clinical Trial Phases:

Phase 4