Condition

Cystic echinococcosis

Clinical trials and treatment information for Cystic echinococcosis

633K
People Affected
8
Active Trials
200K
New Cases/Year
1,364
Deaths/Year

Treatment Rankings

Ranked by evidence volume first. Medicine has spent centuries ranking things by vibes. This is an improvement.

1
Surgical Excision (Pericystectomy/Cystectomy)
95% Effectiveness• 90% Confidence• 50% Safety• 50 trials• 5K participants
HIGH EvidenceModerate Value
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Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
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Chemo☢️
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Morphine💊
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50
DangerousModerateSafe

Time to Effect

Immediate cyst removal, clinical recovery 1-3 months

Duration

Hospital stay 5-10 days, recovery 1-3 months (often combined with pre/post-operative albendazole for 1-3 months)

Response Rate

97%

Remission Rate

95%

Common Side Effects:

Post-operative pain: 90%
Bile leakage: 10%
Wound infection: 7%
Hemorrhage: 3%
Incisional hernia: 10%

Annual Cost of Care

Drug Cost

$750

Monitoring

$1,500

Side Effects

$1,000

Total Annual

$33,250

Cost-Effectiveness

MODERATE

Cost per Remission

$34,947

Cost per Responder

$34,278

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+95%
Response Rate
+97%
Remission Rate
+95%
Common Side Effects
Post-operative pain
+90%
Bile leakage
+10%
Wound infection
+7%

Clinical Trial Phases:

Phase 4
2
PAIR (Puncture, Aspiration, Injection, Re-aspiration) + Albendazole
90% Effectiveness• 88% Confidence• 58% Safety• 40 trials• 4K participants
HIGH EvidenceGood ValueDose: Albendazole 10-15 mg/kg/day in two divided doses
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Comparative Safety Scale(Higher is safer)

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Meth💀
Cigarettes🚬
Chemo☢️
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Morphine💊
Antibiotics💉
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58
DangerousModerateSafe

Time to Effect

Initial improvement within weeks, full resolution 6-12 months

Duration

Single procedure, albendazole for 3-6 months (pre/post-PAIR)

Response Rate

90%

Remission Rate

80%

Common Side Effects:

Local pain/discomfort: 15%
Anaphylaxis (from spillage): 3%
Elevated liver enzymes: 15%
Gastrointestinal upset: 10%
Leukopenia: 5%

Annual Cost of Care

Drug Cost

$1,500

Monitoring

$1,500

Side Effects

$400

Total Annual

$13,400

Cost-Effectiveness

GOOD

Cost per Remission

$16,750

Cost per Responder

$14,889

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+90%
Response Rate
+90%
Remission Rate
+80%
Common Side Effects
Local pain/discomfort
+15%
Anaphylaxis (from spillage)
+3%
Elevated liver enzymes
+15%

Clinical Trial Phases:

Phase 4
3
PAIR (Puncture, Aspiration, Injection, Re-aspiration) Monotherapy
88% Effectiveness• 85% Confidence• 60% Safety• 35 trials• 3.5K participants
HIGH EvidenceGood Value
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Comparative Safety Scale(Higher is safer)

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Meth💀
Cigarettes🚬
Chemo☢️
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Morphine💊
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60
DangerousModerateSafe

Time to Effect

Immediate cyst drainage, clinical improvement within weeks, full resolution 6-12 months

Duration

Single procedure (often followed by short course of albendazole, but not included in 'monotherapy' efficacy)

Response Rate

85%

Remission Rate

80%

Common Side Effects:

Local pain/discomfort: 15%
Anaphylaxis (due to scolex spillage): 3%
Bile leakage: 1%
Secondary infection: 1%

Annual Cost of Care

Drug Cost

$750

Monitoring

$1,500

Side Effects

$200

Total Annual

$12,450

Cost-Effectiveness

GOOD

Cost per Remission

$15,563

Cost per Responder

$14,647

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+88%
Response Rate
+85%
Remission Rate
+80%
Common Side Effects
Local pain/discomfort
+15%
Anaphylaxis (due to scolex spillage)
+3%
Bile leakage
+1%

Clinical Trial Phases:

Phase 4
4
Albendazole
70% Effectiveness• 85% Confidence• 65% Safety• 60 trials• 8K participants
HIGH EvidenceModerate ValueDose: 10-15 mg/kg/day in two divided doses (max 800 mg/day)
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Comparative Safety Scale(Higher is safer)

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Meth💀
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65
DangerousModerateSafe

Time to Effect

3-6 months for initial response

Duration

3-6 months, often in cycles (e.g., 28 days on, 14 days off), up to 2 years for complex cases

Response Rate

70%

Remission Rate

35%

Common Side Effects:

Elevated liver enzymes (transient): 15%
Gastrointestinal upset (nausea, pain): 15%
Leukopenia/Neutropenia: 8%
Alopecia (reversible): 5%
Headache: 8%

Annual Cost of Care

Drug Cost

$3,600

Monitoring

$1,500

Side Effects

$500

Total Annual

$5,600

Cost-Effectiveness

MODERATE

Cost per Remission

$16,000

Cost per Responder

$8,000

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+70%
Response Rate
+70%
Remission Rate
+35%
Common Side Effects
Elevated liver enzymes (transient)
+15%
Gastrointestinal upset (nausea, pain)
+15%
Leukopenia/Neutropenia
+8%

Clinical Trial Phases:

Phase 4
5
Mebendazole
45% Effectiveness• 75% Confidence• 70% Safety• 20 trials• 1.5K participants
MODERATE EvidencePoor ValueDose: 40-50 mg/kg/day in 3 divided doses
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Comparative Safety Scale(Higher is safer)

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Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
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Water💧
70
DangerousModerateSafe

Time to Effect

3-6 months

Duration

3-6 months or longer, continuous treatment

Response Rate

45%

Remission Rate

15%

Common Side Effects:

Gastrointestinal upset: 10%
Headache: 7%
Abdominal pain: 5%

Annual Cost of Care

Drug Cost

$2,400

Monitoring

$1,000

Side Effects

$200

Total Annual

$3,600

Cost-Effectiveness

POOR

Cost per Remission

$24,000

Cost per Responder

$8,000

Treatment Outcomes
Efficacy Outcomes
Overall Effectiveness
+45%
Response Rate
+45%
Remission Rate
+15%
Common Side Effects
Gastrointestinal upset
+10%
Headache
+7%
Abdominal pain
+5%

Clinical Trial Phases:

Phase 4