Bevacizumab (added to chemotherapy)

Treatment for Colon and rectum cancer

Typical Dosage: 5 mg/kg IV every 2 weeks or 7.5 mg/kg IV every 3 weeks (with chemotherapy)

Effectiveness
75%
Safety Score
35%
Clinical Trials
2
Participants
25K

Comparative Safety Scale(Higher is safer)

Cyanide☠️
Meth💀
Cigarettes🚬
Chemo☢️
Alcohol🍺
Morphine💊
Antibiotics💉
Tylenol💊
Exercise🏃
Water💧
35
DangerousModerateSafe
Treatment Details
Dosage Range
5 mg/kg IV every 2 weeks or 7.5 mg/kg IV every 3 weeks (with chemotherapy)
Time to Effect
1-3 months
Treatment Duration
Until progression
Evidence Quality
HIGH
Number Needed to Treat (NNT)
8(Treat 8 patients to see 1 additional successful outcome)
Confidence Score
90%confidence in effectiveness data
Health Economics
Annual Cost of Care
Drug Cost:$110,000
Monitoring:$17,000
Side Effect Mgmt:$15,000
Total Annual:$142,000
Cost-Effectiveness Analysis
Cost-Effectiveness Rating
POOR
ICER
$180,000/QALY
QALYs Gained
0.2
Outcome-Based Costs
Cost per Responder
$236,667
Cost per Remission
$2,840,000
Comparison vs FOLFOX
Cost Difference
+$97,000/year
More expensive
QALY Difference
+0.20 QALYs
Better outcomes
Dominance
No dominance
Bevacizumab (added to chemotherapy) Outcomes

for Colon and rectum cancer

Efficacy Outcomes
Overall Effectiveness
+75%
Response Rate
+60%
Remission Rate
+5%
Common Side Effects
Hypertension
+25%
Proteinuria
+25%
Hemorrhage
+15%
Thromboembolic events
+8%
GI perforation
+2%

Sources:

nih.gov
nih.gov
nih.gov

WARNING: LIMITED TRIALS AVAILABLE

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Active Clinical Trials
No active trials currently recruiting for this treatment

No active trials found in ClinicalTrials.gov

Completed Clinical Trials
2 completed trials for Bevacizumab (added to chemotherapy) in Colon and rectum cancer

Panitumumab and Chemotherapy in Patients With Advanced Colorectal Cancer After Prior Therapy With Bevacizumab

NCT01814501COMPLETEDPHASE2
View Study
16 participants
INTERVENTIONAL
Columbus, United States +1 more
Started: Feb 1, 2013

Combination Chemotherapy and Bevacizumab With or Without Radiation Therapy in Treating Patients With Locally Advanced Rectal Cancer

NCT00462501COMPLETEDNA
View Study
35 participants
INTERVENTIONAL
New York, United States
Started: Mar 1, 2007